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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 8324405 | Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors The present invention relates to novel compounds of formula (I), methods, and compositions capable of decreasing HIF hydroxylase activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). ... | 12/04/2012 |
| 8138357 | Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field Therefore the present invention relates specifically to the compounds of general formula (I), in which R1 and R2, which may be identical or different, are selected from the group comprising H, —CnH2n-1, a linear or branc... | 03/20/2012 |
| 7642364 | Benzopyrone compounds, preparation method and use thereof The invention relates to pesticide and bactericide, specifically to the benzopyrone compounds and its preparation method and use thereof. The benzopyrone compounds of the invention having general formula (I): The present in... | 01/05/2010 |
| 7538233 | Coumarins as iNOS inhibitors The present invention relates to coumarins of the formula (I): that are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions and methods of using these compounds as inhibitors of nitric oxide synthase ... | 05/26/2009 |
| 7439077 | Coumarin analog compounds for safer anticoagulant treatment The present invention relates to the albumin-guided development of coumarin analogs and the analogs developed thereby. The coumarin analogs of the present invention are identified and isolated by the fact that they have binding sites to albumin which are different t... | 10/21/2008 |
| 7411076 | Coumarin derivative A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the following general formula (I): wherein X represents a s... | 08/12/2008 |
| 7256158 | 2,4,5,-trisubstituted phenylketo-enols for use as pesticides and herbicides The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups w... | 08/14/2007 |
| 7235674 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relate... | 06/26/2007 |
| 7148253 | 4-thio coumarins 4-Thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers are provided, as well as processes for their preparation. The invention also provides a method and composition for the treatment of hepatitis C virus (HCV) by a... | 12/12/2006 |
| 7145020 | Materials and methods for treating coagulation disorders This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches met... | 12/05/2006 |
| 7109043 | Fluorescent probe for magnesium ion determination A fluorescent probe for measuring magnesium ion, which can selectively form a complex with magnesium ion in aqueous system is disclosed. The fluorescent probe for measuring magnesium ion according to the present invention has the structure represented by the followi... | 09/19/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
| 7001531 | Sustained release coolant additive composition A coolant additive composition comprising a sustained release component and an additive component, the additive component is effective to provide at least one benefit to a coolant when released into the coolant, the sustained release component includes a polymeric m... | 02/21/2006 |
| 6933417 | Process for vinyl chloride manufacture from ethane and ethylene with partial CHl recovery from reactor effluent A process for producing vinyl chloride monomer from ethylene and ethane having input of significant quantities of both ethane and ethylene in input streams to the affiliated reactor where hydrogen chloride in the reactor effluent is only partially recovered from the... | 08/23/2005 |
| 6921776 | Compound A compound is described. In particular, a non-steroidal sulphamate compound is described. The compound is suitable for use as an inhibitor of oestrone sulphatase. The compound is of general Formula (A), wherein R1... | 07/26/2005 |
| 6909024 | Process for the conversion of ethylene to vinyl chloride and novel catalyst compositions useful for such process This invention is a process for producing vinyl chloride from an ethylene-containing feed, oxygen, and a chlorine source in the presence of a catalyst. The process permits direct production of vinyl chloride in a single reactor system, and further permits ethane to ... | 06/21/2005 |
| 6864279 | Materials and methods for treating coagulation disorders This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches met... | 03/08/2005 |
| 6780887 | Anti-ischemic compounds The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating and/or preventing pathologies associated with ischemia or with mitochond... | 08/24/2004 |
| 6703514 | 4-thio coumarins 4-thio substituted coumarin derivatives and coumarin dimers are provided, as well as processes for their preparation. A synthetic process for the preparation of 4-thio substituted coumarin derivatives is provided using mild reaction conditions, which main... | 03/09/2004 |
| 6677338 | Serotonin transport inhibitors The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.... | 01/13/2004 |
| 6670391 | Benzopyran derivative and antiallergic agent The present invention provides a compound which is highly safe in terms of toxicity and has a stronger antiallergic action, and particularly has an action of inhibiting both immediate and delayed type allergic reactions. A benzopyran derivative represente... | 12/30/2003 |
| 6610862 | Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion The present invention is a method for producing warfarin sodium from warfarin sodium 2-propanol clathrate by thermal, nondestructive solvent expulsion. The solvent expulsion is conducted under conditions of controlled heat transfer whereby the 2-propanol ... | 08/26/2003 |
| 6579902 | Ribose-substituted aromatic amides, method for the production and use thereof as medicaments Compounds of formula (I); wherein R1 =alkyl, alkenyl or alkynyl, O-alkyl, O-alkenyl or optionally substituted, optionally interrupted O-alkynyl; R2 =hydrogen or halogen; R3 =hydrogen, alkyl or halogen; R4 =NHR' ... | 06/17/2003 |
| 6500846 | CDK inhibitors having flavone structure The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase (CDK), a process for preparation thereof, and a composition ... | 12/31/2002 |
| 6486197 | Substance ft-0554 and process for producing the same The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis. The present invention comprising the steps of culturing the microorganism belonging to fungi having producing activity of FT-0554 substance represen... | 11/26/2002 |
| 6471973 | Flavonoide esters and their use notably in cosmetics The invention relates to a flavonoid ester. This flavonoid ester results from the reaction product of at least one flavonoid selected from the group consisting of a flavonoid with a ketone group in the 4-position, a salt, ester or ether of such a flavonoi... | 10/29/2002 |
| 6344330 | Pharmacophore recombination for the identification of small molecule drug lead compounds The present invention is directed to novel methods for identifying small molecule ligands that are capable of binding with high affinity to a biological target molecule of interest. High affinity binding ligands identified by the described methods find us... | 02/05/2002 |
| 6344334 | Pharmacophore recombination for the identification of small molecule drug lead compounds Method for identifying a drug lead compound that inhibits binding of target bioogical molecules (TBM) by contacting TBM with members of a library of candidate cross-linked target binding fragments (CXBF), each CXBF having at least two candidate target bin... | 02/05/2002 |
| 6303796 | ଲ-diketone compounds ଲ-diketone compounds coordinated to metal, method of organic synthesis with these, and catalyst The present invention provides a novel ଲ-diketone compound represented by formula (3): ##STR1## [wherein X represents (CH2)n ; n represents an integer of 2-20; and the CH2 of X may be replaced by an oxygen atom, a he... | 10/16/2001 |
| 6291518 | Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: ##STR1## wherein R1 =R2 =4-hydroxycoumarin; R1 =R | 09/18/2001 |
| 6251830 | Dialkyl-halogenophenyl-substituted ketoenols The present invention relates to new compounds of the formula (I) ##STR1## in which X represents alkyl, Y represents halogen or alkyl and Z represents halogen or alkyl, with the proviso that one of the radicals Y and Z always represents halogen and the other a... | 06/26/2001 |
| 6235294 | Flavonoide esters and their use notably in cosmetics The invention relates to a flavonoid ester. This flavonoid ester results from the reaction product of at least one flavonoid selected from the group consisting of a flavonoid with a ketone group in the 4-position, a salt, ester or ether of such a flavonoi... | 05/22/2001 |
| 6124477 | Anti-first-pass effect compounds The present inventor has discovered chemical compounds which inhibit the first-pass effect of orally administered drugs in humans; that phototoxic low molecular weight furocoumarins and certain ether-substituted furocoumarins that are naturally present in... | 09/26/2000 |
| 6114546 | Aminomethylene derivatives and ultraviolet absorbent comprising thereof The present invention provides an aminomethylene derivative represented by general formula (I): ##STR1## wherein A is a cyclic oxo group selected from the group consisting of following general formulae (a), (b), (c), (d) and (e): ##STR2## w... | 09/05/2000 |
| 6083978 | Compounds with a sulfamate group A sulphamate compound suitable for use as an inhibitor of both oestrone sulphatase activity and aromatase activity. The compound can have the general formula (II) wherein F represents a phenolic ring structure (the first ring structure), J represents the ... | 07/04/2000 |
| 6034121 | Chromone fungicides Compounds of the formula ##STR1## where one of Z and Y is CO and the other is C--W--R2 and the dotted line indicates a double bond is present where necessary to meet valency requirements, W is O, S(O)n, N(R3), N(R | 03/07/2000 |
| 5985912 | 4-hydroxy coumarin derivatives Compounds of the formula The compounds are useful in the treatment of bacterial infections.... | 11/16/1999 |
| 5981495 | Benzopyran derivative and method for treating heart disease using this derivative The present invention offers a safe and effective drug for heart diseases and a safe and effective method for treating heart diseases such as ischemic heart disease and cardiac arrhythmia. The method comprises administering a pathologically effective amou... | 11/09/1999 |
| 5980593 | Silent fluorescent petroleum markers Liquid petroleum products and industrial liquids are marked with highly soluble silent fluorescent markers having the formula: ##STR1## where R is selected from a linear or branched C1 -C18 alkylcarboxy radical.... | 11/09/1999 |
| 5968940 | Retinoids and methods of use of same New purine retinoid compounds according to the formula: ##STR1## wherein R is a purine derivative, and pharmaceutical compositions thereof, are provided which exhibit cancer-inhibiting activity.... | 10/19/1999 |
