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| Number | Title | Issue Date |
| 7498449 | Antiarrhythmic precursor compounds, methods of synthesis and methods of use The invention comprises compounds of Formula 1: wherein, R1 is independently H or halogen; R2 is, for example, H or —R10—NR11R12, and wherein R10 is C | 03/03/2009 |
| 7473789 | 9-(1′,5′-dimethyl-1′-vinyl -4′- hexenyl)-4-hydroxy-7H-furo[3,2-γ] [1] benzopyran-7-one as antibacterial agent The object of the present invention is to provide an antibacterial agent which has an improved antibacterial effect and a wider antibacterial spectrum than conventional antibacterial agents, and which is highly safe to human and the environment. This object is achie... | 01/06/2009 |
| 7384975 | Substituted furochromenes, preparation thereof and their antiinflammatory action The invention relates to novel compounds of the formula (I) including all their tautomers, to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof, and ... | 06/10/2008 |
| 7220747 | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and r... | 05/22/2007 |
| 7208518 | Substituted furochromene compounds of antiinflammatory action The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive ... | 04/24/2007 |
| 7145020 | Materials and methods for treating coagulation disorders This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches met... | 12/05/2006 |
| 7115655 | Pyranocoumarin derivatives The present invention relates to compounds of the following formula (I) or pharmaceutically acceptable salts thereof. The present invention also relates to use for a cognitive-enhancing agent of compounds of the following formula (I) or pharmaceutically acceptable s... | 10/03/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
| 7049110 | Inactivation of West Nile virus and malaria using photosensitizers Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic a... | 05/23/2006 |
| 7037642 | Removing compounds from blood products with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly po... | 05/02/2006 |
| 6951713 | Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent p... | 10/04/2005 |
| 6924373 | DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also r... | 08/02/2005 |
| 6858742 | DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also r... | 02/22/2005 |
| 6768007 | Substituted 3′,4′-di-O-camphanoyl-(+)-cis-khellactone analogs, compositions thereof, and methods for using thereof 3′,4′-di-O-camphanoyl-(+)-cis-khellactone analogs according to the present invention have been found to have anti-HIV activity. The compounds of the present invention have the following formula: or a pharmaceutically... | 07/27/2004 |
| 6734313 | Synthesis of spiro esters, spiro ortho carbonates, and intermediates Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathw... | 05/11/2004 |
| 6686480 | Compounds for the photodecontamination of pathogens in blood Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in ... | 02/03/2004 |
| 6670383 | Pyranocoumarin compounds as a novel pharmacophore with anti-TB activity The present invention relates to compounds and compositions useful in treating or preventing conditions and diseases related to Mycobacterium infection, and methods of use directed thereto.... | 12/30/2003 |
| 6613918 | Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synt... | 09/02/2003 |
| 6503699 | Method for photodecontamination of pathogens in blood using 5'-primary aminopsoralens Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in ... | 01/07/2003 |
| 6469052 | Compounds for the photodecontamination of pathogens in blood The present invention includes compositions comprising new psoralens with either a 4 ', or 5 'primary amino substituent and a blood product that is suitable for in vivo use. The compositions are useful for the inactivation of pathogens in blood products s... | 10/22/2002 |
| 6420571 | Methods for preparing antiviral calanolide compounds The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy -10-propyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10 -propyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-8-one (6) and their use as intermediates for th... | 07/16/2002 |
| 6420570 | Psoralen compounds Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in ... | 07/16/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6319929 | Suksdorfin analogs, compositions thereof, and methods for making and using thereof The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula IV: ##STR1## wherein R20 through R26, M and Z are defined herein. The ... | 11/20/2001 |
| 6313320 | Process for the preparation of calanolide precursors The present invention concerns compounds of the formula ##STR1## wherein R1, R2, R3, R4 and R6 each represent H or an organic group of up to 20 C atoms, or any pair of R2 and R3 ... | 11/06/2001 |
| 6255337 | Anti-first-pass effect compounds and citrus extract First-pass effective substances derived from citrus.... | 07/03/2001 |
| 6255324 | Amino-and mercurio-substituted 4',5'-dihydropsoralens and therapeutical uses thereof 5'-substituted, 4',5'-dihydropsoralen compounds (5) bearing tertiary amines (and salts thereof), quaternary ammonium moieties or organomercurial moieties are described. ##STR1## Also described are 2-substituted mercurimethyl-2-3-dihydro-benzofurans of ... | 07/03/2001 |
| 6177424 | 4'-Substituted-4',5'-dihydropsoralens and therapeutical uses thereof The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula(V): ##STR1## In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR1 R2, or (N+ R1 | 01/23/2001 |
| 6169109 | Method of inactivation of viral and bacterial blood contaminants Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.... | 01/02/2001 |
| 6160006 | 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit The present invention provides a composition and methods for inhibiting cytochrome P450 enzyme activity and in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. The present invention provides 6',7'-... | 12/12/2000 |
| 6133460 | Psoralens for pathogen inactivation Psoralen compound compositions are synthesized which have primaryamino substitutions on the 3-, 4-, 5-, and 8- positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these psoralens r... | 10/17/2000 |
| 6124477 | Anti-first-pass effect compounds The present inventor has discovered chemical compounds which inhibit the first-pass effect of orally administered drugs in humans; that phototoxic low molecular weight furocoumarins and certain ether-substituted furocoumarins that are naturally present in... | 09/26/2000 |
| 6054449 | Compounds and method for PDT of intimal hyperplasia and other diseases A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo... | 04/25/2000 |
| 6043271 | Method for the preparation of (&#b1;)-calanolide A and intermediates thereof A method of preparing (&#b1;)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (&#b1;)-calanolide A and its derivatives are also provided. According to the disclosed method, chr... | 03/28/2000 |
| 6017691 | 4'-primary aminopsoralen and platelet compositions Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in sa... | 01/25/2000 |
| 5990154 | Anti-first-pass effect compounds and citrus extract This invention relates to the process of making citrus (preferably grapefruit) extract having reduced levels of phototoxic furocoumarins and containing enhanced amounts of one or more anti-first pass effect compounds.... | 11/23/1999 |
| 5981770 | Method for the preparation of (+)-calanolide A and analogues thereof A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to... | 11/09/1999 |
| 5981495 | Benzopyran derivative and method for treating heart disease using this derivative The present invention offers a safe and effective drug for heart diseases and a safe and effective method for treating heart diseases such as ischemic heart disease and cardiac arrhythmia. The method comprises administering a pathologically effective amou... | 11/09/1999 |
| 5977385 | Method for the preparation of (+)-calanolide A and analogues thereof A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to... | 11/02/1999 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
