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| Number | Title | Issue Date |
| 8148551 | Tricyclic aromatics and liquid-crystalline medium The invention relates to tricyclic aromatics of the general formula I in which A1, A2, A3, A4, Q1-Q2, R1, R2, X1, X2 | 04/03/2012 |
| 7629475 | Salvinorin derivatives and uses thereof The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvi... | 12/08/2009 |
| 7341715 | Method and agents on the basis of 2-mercaptopropionic acid amides for durable hair forming and a method for producing same The preparation for permanently deforming hair has a pH of 6.5 to 9.5 and contains, as keratin-reducing agent, a 2-mercaptopropion-amide of the formula (I): in which R1 and R2, independently of one ano... | 03/11/2008 |
| 7326447 | Benzochromene derivatives The present invention relates to benzochromene derivatives of the formula I in which the various parameters are as defined in the text, and to liquid-crystal media which comprise these compounds, and to the use o... | 02/05/2008 |
| 7321047 | Separation of tetrahydrocannabinols An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I: R—(CH2)n—N═C═X (I) | 01/22/2008 |
| 7285683 | Bicyclic and tricyclic cannabinoids Novel bicyclic-cannabinoids and hexahydrocannabinol analogs are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause... | 10/23/2007 |
| 7214690 | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described. ... | 05/08/2007 |
| 7183313 | Keto cannabinoids with therapeutic indications Novel tricyclic cannabinoid compounds are presented. Some of these compounds exhibit fluorescence properties. The fluorescent cannabinoid compounds are typically endogenously fluorescent. Some of these compounds, when administered in a therapeutically effective amou... | 02/27/2007 |
| 7169942 | Cannabinoid derivatives, methods of making, and use thereof 1′-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having ac... | 01/30/2007 |
| 7151139 | Antimicrobial polymeric surfaces Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common material... | 12/19/2006 |
| 7084151 | 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro--chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 08/01/2006 |
| 7071205 | 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 07/04/2006 |
| 7057076 | Bicyclic and tricyclic cannabinoids Novel bicyclic-cannabinoids and hexahydrocannabinol analogs are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause... | 06/06/2006 |
| 6995187 | Peripheral cannabinoid receptor (CB2) selective ligands Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals for treatment of ... | 02/07/2006 |
| 6964973 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 11/15/2005 |
| 6939977 | Analgesic and immunomodulatory cannabinoids Disclosed are novel compounds represented by the following structural formula: R-X-Y; and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted cannabinoid. ... | 09/06/2005 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6906203 | Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to ... | 06/14/2005 |
| 6800765 | Fluorescent pH indicators for intracellular assays Systems, including compositions and methods, for measuring pH, particularly in cells, organelles, and other samples. The compositions include pH-sensitive fluorescent and fluorogenic 2′,7′-dialkylfluorescein derivatives and associated nonfluorescent precursor co... | 10/05/2004 |
| 6784204 | Antibiotic cytosporacin This disclosure describes new antibiotic Cytosporacin having the structure: The invention relates to a new antibiotic designated Cytosporacin, to its production by fermentation, to methods for its recovery and concentrat... | 08/31/2004 |
| 6632835 | Dibenzo[c]chromen-6-one derivatives as anti-cancer agents Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either... | 10/14/2003 |
| 6613797 | Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins Therapeutic compounds and compositions for the treatment of infectious diseases are disclosed. The compounds are xanthones and xanthone derivatives, such as 3,5-bis-&3xb5;-(N,N-diethylamino)amyloxyxanthone. The described compositions include such compound... | 09/02/2003 |
| 6383666 | Organometallic complex and organic electroluminescent device using the same Disclosed are new organometallic complex molecules having light-emitting and electron-transporting characteristics. Also disclosed is organic EL (electroluminescent) devices using these organometallic complex molecules as electron-transporting materials. ... | 05/07/2002 |
| 6348603 | Process for the preparation of isochroman-3-ones The present invention relates to a process for the preparation of an isochroman-3-one of the formula (I) ##STR1## by reaction of a 1,2-bishalomethylbenzene of the formula (II) ##STR2## in which X is chlorine, bromine or iodine, with carbon monoxide and a ... | 02/19/2002 |
| 6319929 | Suksdorfin analogs, compositions thereof, and methods for making and using thereof The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula IV: ##STR1## wherein R20 through R26, M and Z are defined herein. The ... | 11/20/2001 |
| 6284220 | Noninvasive imaging of nucleic acid vectors Nucleic acid-imaging compositions and methods for noninvasive imaging of a nucleic acid introduced into somatic tissues of an animal or human are disclosed. The noninvasive imaging enables quantitative assessment of the biodistribution of the introduced n... | 09/04/2001 |
| 6239169 | Non-steroidal polycyclic ring sulphamate derivatives, their preparation and their use as oestrone sulphatase inhibitors A non-steroidal compound suitable for use as an inhibitor of oestrone sulphatase. The compound has a polycyclic ring structure comprising two or more rings wherein at least two of the rings mimic the A and B rings of oestrone. The compound can have the ge... | 05/29/2001 |
| 6215006 | Process for the preparation of 3-isochromanoes by cyclization of o-chloromethylphenylacetic acids The present invention relates to a process for the preparation of a 3-isochromanone of the formula (I) ##STR1## by reaction of an o-chloromethylphenylacetic acid of the formula (II) ##STR2## at a temperature of 100 to 250° C. in the presence or absence o... | 04/10/2001 |
| 6172241 | Process for the preparation of 1,2-dihydroquinolines A method for preparing 1,2-dihydroquinolines that is more flexible than the Skraup reaction is provided. The method comprises treating an ortho-alkenyl aniline with a ketone in the presence of a Lewis acid. Novel intermediates and products of this method ... | 01/09/2001 |
| 6166066 | Cannabinoids selective for the CB2 receptor Disclosed are novel cannabinoids which are selective for the CB2 receptor. The novel cannabinoids comprise a substituted or unsubstituted tricyclic cannabinoid core and a substituted or unsubstituted C5-C8 carbocyclic ring, five to eight-membered heterocy... | 12/26/2000 |
| 6083978 | Compounds with a sulfamate group A sulphamate compound suitable for use as an inhibitor of both oestrone sulphatase activity and aromatase activity. The compound can have the general formula (II) wherein F represents a phenolic ring structure (the first ring structure), J represents the ... | 07/04/2000 |
| 6011058 | Seco-cholestane derivatives and methods of making the same The present invention is directed to novel seco-cholestane derivatives, as well as to pharmaceutical compositions thereof, and methods of making the same. More particularly, the invention relates to C5- and C8-substituted seco-cholestane derivatives. The ... | 01/04/2000 |
| 6005093 | Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents Novel coumarin derivatives comprising a coumarin moiety linked to a non-nucleosidic backbone moiety are disclosed. The resulting molecules are typically used as photoactivate cross-linking groups when incorporated into polynucleotides as replacements for ... | 12/21/1999 |
| 5847165 | Suksdorfin analogs, compositions thereof, and methods for making and using thereof Disclosed are compounds of Formula I: ##STR1## wherein R1 through R6 are defined herein. Also disclosed are pharmaceutical compositions and methods of using these compositions for treating retroviral infections. Finally, a stere... | 12/08/1998 |
| 5726204 | Suksdorfin analogs, compositions thereof, and methods for making and using thereof The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula I: ##STR1## wherein R1, R2, R3, R4, R5... | 03/10/1998 |
| 5665330 | Dual purposed diagnostic/therapeutic agent having a tri-iodinated benzoyl group linked to a coumarin The invention provides a novel compound having the structure ##STR1## wherein R is alkyl and R1, R2, R3 and R4 are each independently OCH3, H or I and n is 0 or 1 and m is 0 or 1. The compound is useful in a method of treating mammals either therapeu... | 09/09/1997 |
| 5504104 | Tricyclic pyrone derivatives as protease inhibitors and antiviral agents The present invention relates to novel substituted tricyclic pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The tricyclic pyrone derivatives are useful in the development of therapies for the trea... | 04/02/1996 |
| 5473083 | Reduced and quaternized psoralens as photo-activated therapeutics The invention features phototherapeutic compositions comprising Type 1, Type 2, or Type 3 psoralens and methods of using such compounds for treatment of proliferative diseases of skin, blood and bone marrow.... | 12/05/1995 |
| 5300646 | Heterocyclic amine derivatives, their production and use A novel heterocyclic amine derivative of the general formula: ##STR1## wherein a ring A and a ring B stand independently for an optionally substituted benzene ring, Zo stands for O or S or ##STR2## stands for --CH2 --, X st... | 04/05/1994 |
| 5264454 | Certain 2-oxo-tetrahydro-cycloalkyl-benzopyran-3yl ureas having acyl-CoA-cholesterol acyl transferase inhibitory activity Novel heterocyclic compound of the general formula: ##STR1## wherein ring A and ring B each means a benzene ring which is substituted or unsubstituted; X means a group of the formula: ##STR2## wherein R2 is hydrogen, an alkyl or an al... | 11/23/1993 |
