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| Number | Title | Issue Date |
| 8115017 | C-phenyl 1-thioglucitol compound C-phenyl 1-thioglucitol compounds of the following formula (I) or pharmaceutically acceptable salts thereof or hydrates thereof: [wherein X represents a hydrogen atom or a C1-6 ... | 02/14/2012 |
| 8093406 | Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to ... | 01/10/2012 |
| 8017792 | 1-thio-D-glucitol derivatives The present invention provides a 1-thio-D-glucitol compound of the following formula, which shows the action of inhibiting the activity of SGLT2, a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the salt; and a pharmaceutical compr... | 09/13/2011 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7414072 | Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same There is provided a 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly... | 08/19/2008 |
| 7354957 | Multi-functional thioxanthone photoinitiators Compounds of formula (I): {where n is a number from 1 to 6; R3 is hydrogen, methyl or ethyl; A represents a group of formula —[O(CHR2CHR1)a]y—,—[O(CH2)bCO]y—, or —[O(CH... | 04/08/2008 |
| 7351742 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 04/01/2008 |
| 7253940 | Nanoporous and nanocrystalline film and electrochromic device A nanoporous, nanocrystalline film and electrochromic device. The nanoporous, nanocrystalline film has a conducting metal oxide having an electroactive compound, which is either a p-type or n-type redox promoter or p-type or n-type redox chromophore, absorbed theret... | 08/07/2007 |
| 7250522 | Method for selective preparation of aryl 5-thio-β-D-aldohexopyranosides The present invention provides a method for preparing an aryl 5-thio-β-D-aldohexopyranoside derivative of Formula (III), which comprises reacting a 5-thio-D-aldohexopyranose derivative of Formula (I) with Ar-OH of Formula (II) in the presence of a phosphine represe... | 07/31/2007 |
| 7241810 | Formamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds accord... | 07/10/2007 |
| 7138529 | Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the... | 11/21/2006 |
| 7112683 | Cyclic sulfone containing retroviral protease inhibitors The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease. ... | 09/26/2006 |
| 7105518 | Thiopyrane-4-ones as DNA protein kinase inhibitors The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R1 and R2 are independently hydrogen, an option ally substituted C1-7 alkyl group, C... | 09/12/2006 |
| 7081436 | Paste formulation for seed treatment of plants Disclosed herein is a composition comprising a seed treatment formulation and an organosilicone additive of the formula: wherein: X is a number from 0 to 30; Y ... | 07/25/2006 |
| 7053115 | Crystalline form of dorzolamide hydrochloride The present invention relates to a novel crystalline form of dorzolamide hydrochloride, to processes for its preparation and a pharmaceutical composition containing it. ... | 05/30/2006 |
| 6905786 | Light emitting device material, light emitting device using thereof, and amine compound A compound represented by the following formula (I): wherein R1, R2 and R3each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group, provided that at least o... | 06/14/2005 |
| 6875790 | Cyclic sulfone containing retroviral protease inhibitors The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease. ... | 04/05/2005 |
| 6849203 | Photoisomerizable compounds The invention relates to photoisomerizable compounds of formula I wherein A, Z, L, R, R1, k, m and r are defined herein. ... | 02/01/2005 |
| 6849660 | Antimicrobial biaryl compounds Provided are antibacterial compounds having Formula I: In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1′ is —C(O)NR5R5′ | 02/01/2005 |
| 6846843 | β-thioamino acids Thio-alpha-amino acids of general formula (I), wherein R1, R2 and R3 have the meanings given in the description, methods for producing them, and medicaments containing these compounds. The invention also provides methods for treating... | 01/25/2005 |
| 6828276 | Herbicidally active benzoylcyclohexanediones There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radic... | 12/07/2004 |
| 6809207 | Amino acid derivatives The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydroth... | 10/26/2004 |
| 6803129 | Organic light emitting diode and organic luminescent materials thereof The present invention relates to an organic light emitting diode (OLED) device, comprising an anode disposed on a substrate, an organic EL layer disposed on the anode and a cathode disposed on the organic EL layer. The material of the organic EL layer comprises a co... | 10/12/2004 |
| 6750233 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibitin... | 06/15/2004 |
| 6677355 | Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors Compounds of the formula; ##STR1## are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such ... | 01/13/2004 |
| 6664272 | Curcumin analogs with anti-tumor and anti-angiogenic properties The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.... | 12/16/2003 |
| 6552203 | Cyclic sulfone containing retroviral protease inhibitors The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.... | 04/22/2003 |
| 6514633 | Light emitting device material, light emitting device using thereof, and amine compound A light emitting device material comprising a compound represented by the following formula (I): ##STR1## wherein R1, R2 and R3, which may be the same or different, each represents an aryl group, a heterocyclic group or an... | 02/04/2003 |
| 6479671 | Process for producing optically active chromene derivative A process for producing a compound of the formula (II): ##STR1## (wherein R1, R2, R3 and R4 are each independently hydrogen, alkyl, alkoxy or the like, R5 is alkyl or alkoxyalkyl, A is O or S, Ar is a... | 11/12/2002 |
| 6455573 | Glycosidase inhibitors and methods of synthesizing same A method for synthesizing Salacinol, its stereoisomers, and non-naturally occurring selenium and nitrogen analogues thereof having the general formula (I): ##STR1## The compounds are potentially useful as glycosidase inhibitors. The synthetic schemes... | 09/24/2002 |
| 6451766 | Neuraminic acid derivatives, their preparation and their medical use Compounds of formula (I) or their salts or esters: ##STR1## [wherein R1 is alkyl or haloalkyl; R2 and R3 each represents hydrogen or aliphatic acyl; X is hydroxy, halogen, alkoxy, or a group of formula Ra O--, w... | 09/17/2002 |
| 6441023 | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 08/27/2002 |
| 6417221 | Tropane analogs and methods for inhibition of monoamine transport New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7- substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain p... | 07/09/2002 |
| 6410748 | Alicycli c group-containing monomer A monomer represented by the following general formula (m-1): ##STR1## wherein R is a group having an alicyclic skeleton, R2 s may be the same or different and are individually hydrogen atom, halogen atom or monovalent organic group, X1 | 06/25/2002 |
| 6380258 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroa... | 04/30/2002 |
| 6369225 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6350761 | Benzenamine derivatives as anti-coagulants This invention is directed to benzenamine derivatives of formula (I): ##STR1## wherein A, W, m, n, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants.... | 02/26/2002 |
| 6342511 | Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous syste... | 01/29/2002 |
| 6313162 | Propynyl or dienyl biaromatic compounds The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, ... | 11/06/2001 |
| 6310245 | 3-aminocarbonyl/3-aminothiocarbonyl-substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, --OR5, --OCOR6, ... | 10/30/2001 |
