In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
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| Number | Title | Issue Date |
| 7208518 | Substituted furochromene compounds of antiinflammatory action The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive ... | 04/24/2007 |
| 6503941 | Ferulic ester derivative, 3,9-diferulylcoumestrol and cosmetic product containing same The present invention relates to a skin cosmetic product containing 3,9-diferulylcoumestrol, especially to a skin cosmetic product containing a compound in which ferulylic acid is bonded to a coumestrol. The skin cosmetic product has several excellent eff... | 01/07/2003 |
| 5985913 | Tetracyclic compounds for enhancing biosynthesis of erythropoietin, compositions containing same, and methods of use thereof The present invention provides a compound in substantially pure form having the structure: ##STR1## wherein each of R1, R2, R3, R4, R5, R6, R7, and R8 may indepen... | 11/16/1999 |
| 5216175 | Antimalarial analogs of artemisinin Polyoxoheterocyclic tetracycles related to the Chinese antimalarial natural product qinghaosu (artemisinin) are disclosed. These materials have a ##STR1## core structure with an oxygen (carbonyl or alkyl ether) at position 12 and in some cases one or... | 06/01/1993 |
| 5019590 | Antimalarial analogs of artemisinin A process for synthesizing oxygen-containing polyoxatetracycle compounds and in particular analogs of the antimalarial agent known as qinghaosu or artemisinin is disclosed. The process employs as a reactant an olefinically unsaturated bicyclic bridging ke... | 05/28/1991 |
| 4997848 | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl of hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkad... | 03/05/1991 |
| 4992561 | Simple conversion of artemisinic acid into artemisinin This invention relates to a novel process for producing artemisinin from emisinic acid. The artemisinic acid is reduced to dihydroartemisinic acid by reduction of the exocyclic methylene group. The dihydroartemisinic acid is then oxidized in two successi... | 02/12/1991 |
| 4963683 | Process for preparing polyoxa tetracyclic compounds A process for synthesizing polyoxa tetracyclics which involves the ozonolysis of a single-ring-structure vinyl silane with resulting direct formation of the desired multiple ring matrial. The polyoxa tetracyclic compounds have the formula ##STR1## ... | 10/16/1990 |
| 4219489 | Synthesis of steroids Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and... | 08/26/1980 |
| 4108898 | Asymmetric synthesis of organic compounds Optically active organic compounds are prepared starting from optically inactive reactants by means of an optically active agent which influences the course of the reaction. In particular optically active compounds having a "meso" type carbon atom undergo... | 08/22/1978 |
| 4064185 | Olefinically unsaturated substituents at C-11 of steroid cyclization precursors Compositions are provided as well as methods for preparing the compositions which serve as cyclization precursors for the preparation of C-11 alkenyl substituted steroids and nor-steroids. The alkenyl group may be converted after cyclization to a variety ... | 12/20/1977 |