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| Number | Title | Issue Date |
| 7642363 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-YL) acetic acid derivatives The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon at... | 01/05/2010 |
| 7491833 | Valerolactone compounds and perfume composition A valerolactone compound represented by the formula (I): wherein each of R1 and R2 is independently a hydrogen atom, a methyl group or an ethyl group wherein when R1 is a hydrogen atom, R | 02/17/2009 |
| 7341818 | Norbornene-type monomers and polymers containing pendent lactone or sultone groups The disclosed invention relates to novel norborne-type monomers containing pendent lactone or sultone groups. The invention also relates to norborne-type polymers and copolymers containing pendent lactone or sultone groups. These polymers and copolymers are useful i... | 03/11/2008 |
| 7314942 | Methylenelactones syntheses in supercritical fluids Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid. ... | 01/01/2008 |
| 7230125 | Methods of performing cycloadditions, reaction mixtures, and methods of performing asymmetric catalytic reactions Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods ... | 06/12/2007 |
| 7214708 | Synthetic discodermolide analogs Synthetic discodermolide analogs having utility as antiproliferative agents, having a structure represented by formula A where RA through RE and XA are as defined herein. ... | 05/08/2007 |
| 7192982 | Modulators of peroxisome proliferator activated receptors Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or uns... | 03/20/2007 |
| 7183421 | Processes for producing oxide with higher oxidation than alcohol The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presen... | 02/27/2007 |
| 7141602 | Process for obtaining HMG-CoA reductase inhibitors of high purity Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of d... | 11/28/2006 |
| 7101654 | Norbornene-type monomers and polymers containing pendent lactone or sultone groups The disclosed invention relates to novel norbornene-type monomers containing pendent lactone or sultone groups. The invention also relates to norbornene-type polymers and copolymers comprising one or more repeating units represented by the formula: | 09/05/2006 |
| 7067677 | Production of dihydronepetalactone by hydrogenation of nepetalactone This invention relates to a process for hydrogenating nepetalactone, utilizing a metal catalyst that is optionally supported, to yield dihydronepetalactone. A suite of supported catalytic metals lead to rapid hydrogenation and high selectivity for dihydronepetalacto... | 06/27/2006 |
| 7057077 | Method for producing 2- (alkyl) cycloalkenone A method for producing 2-(alkyl)cycloalkenone and a method for producing alkyl(3-oxo-2-alkylcycloalkyl) acetate and 5-alkyl-5-alkanolide which are useful as flavoring materials and physiologically active substances using the same are provided. A method for producing... | 06/06/2006 |
| 6960573 | Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following for... | 11/01/2005 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6933395 | PROCESSING FOR PRODUCING OF DROSPIRENONE (6β, 7β, 15β, 16β-DIMETHYLENE-3-OXO-17α-PREGN-4-EN-21, 17-CARBOLACTONE, DRSP) AS WELL AS 7α-(3-HYDOXY-1-PROPLY)-6β, 7β; 15β, 16β-DIMETHYLENE-5β-ANDROSTANE-3β, 5,17β-TRIOL(ZK 92836) AND 6β, 7β; 15β, 16β-DIMETHYLENE-5β-HYDROXY Process for the production of drospirenone (6β,7β; 15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, DRSP) (1) and 7α-(3-hydroxy-1-propyl)-6β,7β; 15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (ZK 92836) and 6β,7β; 15β,16β-dimethylene-... | 08/23/2005 |
| 6870058 | Compounds which mimic the chemical and biological properties of discodermolide Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation. ... | 03/22/2005 |
| 6818638 | Melvinolin derivatives Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions. ... | 11/16/2004 |
| 6809214 | Shortened synthesis of 3,3-diarylpropylamine derivatives The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions. ... | 10/26/2004 |
| 6797830 | Process for producing oxide with higher oxidation than alcohol The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presen... | 09/28/2004 |
| 6787655 | Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, the transitio... | 09/07/2004 |
| 6768013 | Intrinsically safe oxidation process A novel process for the direct oxidation of hydrogen and hydrocarbons is disclosed, where the explosion risks inherent in gas phase oxidations are substantially eliminated. Gaseous oxidation reactants are soluble in a first reaction solvent phase such as a perfluoro... | 07/27/2004 |
| 6713036 | Process for mixing and reacting two or more fluids A novel process for continuously mixing and reacting at least two fluids are disclosed. Excellent mixing and superior pressure drop characteristics are achieved using cyclone mixing where at least two supply channels feed a mixing chamber to create a vortex of the f... | 03/30/2004 |
| 6673780 | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucos... | 01/06/2004 |
| 6660448 | Polymer, resist composition and patterning process The invention provides a polymer comprising recurring units containing bridged aliphatic rings in the backbone and having a hydroxyl, acyloxy or alkoxylcarbonyloxy group as well as a lactone structure bonded through a spacer, the polymer having a weight a... | 12/09/2003 |
| 6649776 | Methylenelactone synthesis in supercritical fluids Alpha-methylenelactones are produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid in the presence of a catalyst and a phase transfer agent.... | 11/18/2003 |
| 6630492 | Lymphocyte function antigen-1 antagonists Mevinolin compounds for use in the treatment or prevention of autoimmune diseases, inflammation, ischemia/reperfusion injury and graft rejection. Such compounds bind to the LFA-1 I-domain and thereby inhibit LFA-1/ICAM-1 or LFA-1/ICAM-3 interactions.... | 10/07/2003 |
| 6627763 | Compounds having protected hydroxy groups The present invention relates to compounds with protected hydroxy groups of formula (I) ##STR1## These compounds are precursors for organoleptic agents, such as fragrances, and masking agents and for antimicrobial agents. When activated, the compound... | 09/30/2003 |
| 6592845 | Estrogens for treating ALS A method for preventing and treating ALS by administering a phytoestrogen, preferably genistein.... | 07/15/2003 |
| 6559322 | Process for preparation of a lactone from a cyclic ketone The present invention provides a new biocatalyst whole cell system for converting cyclic ketones such as cyclopentanone/cyclohexanone to the corresponding lactones such as valerolactone/caprolactone. Another novel aspect of the present invention is that b... | 05/06/2003 |
| 6531460 | Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same Compounds expressed by the following general formula (1), ##STR1## ##STR2## The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes melli... | 03/11/2003 |
| 6531616 | Process for the preparation of a-methylenelactones and a-substituted hydrocarbylidene lactones This invention pertains to a process for making -methylenelactones and -substitute hydrocarbylidene lactones. More specifically, the present invention obtains high yields of -methylene-γ-butyrolactone by heating γ-butyrolactone ... | 03/11/2003 |
| 6506910 | Process for preparing discodermolide and analogues thereof A more practical synthesis for preparing discodermolide and structurally related analogues, novel compounds useful in the process and novel compounds prepared by the process.... | 01/14/2003 |
| 6500961 | Lactone compounds having alicyclic structure and their manufacturing method Lactone compounds of formula (1) are useful as monomers to form base resins for use in chemically amplified resist compositions adapted for micropatterning lithography. ##STR1## R1 is H or C1-6 alkyl, R2 is H or an acyl or... | 12/31/2002 |
| 6492532 | Method for producing carbonyl compound by dehydrogenating alcohol The present invention provides a method for producing a carbonyl compound by dehydrogenating an alcohol. Namely, it relates to a method for producing a carbonyl compound, which comprises dehydrogenating an alcohol in the presence of a complex compound cat... | 12/10/2002 |
| 6465664 | Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, th... | 10/15/2002 |
| 6462206 | Catalytic reduction of ketones and aldehydes using organometallic ruthenium complexes Ketones and aldehydes are hydrogenated to the corresponding alcohol or alkyl group, using H2 gas as the stoichiometric reductant, and organometallic ruthenium complexes as the catalysts.... | 10/08/2002 |
| 6437150 | Compounds having protected hydroxy groups The present invention relates to compounds with protected hydroxy groups of formula (I) ##STR1## These compounds are precursors for organoleptic agents, such as fragrances, and masking agents and for antimicrobial agents. When activated, the compound... | 08/20/2002 |
| 6433197 | Substituted oxygen alicyclic compounds, including methods for synthesis thereof The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen com... | 08/13/2002 |
| 6403777 | Metalloligands for cleaving nucleic acids Transition metal complexes, referred to hereinafter as "metalloligands", that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the metalloligand has the following structure: ##STR1## wherein R1 ... | 06/11/2002 |
| 6334998 | Estrogens for treating ALS A method for preventing and treating ALS by administering a phytoestrogen, preferably genistein.... | 01/01/2002 |
