Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7968736 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a b... | 06/28/2011 |
| 7667052 | Bioactive substance The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incuba... | 02/23/2010 |
| 7626043 | Antiproliferative activity of the leiodermatolide class of macrolides The subject invention provides novel biologically active compounds that have utility for use in inhibiting cellular proliferation. Pharmaceutical compositions comprising these compounds are also provided. In a specific embodiment, the compounds and compositions of t... | 12/01/2009 |
| 7569576 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods o... | 08/04/2009 |
| 7378508 | Polymorphic crystalline forms of tiacumicin B The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such co... | 05/27/2008 |
| 7358275 | Internal 1,15-lactones of fluprostenol and related prostaglandin F2a analogs and their use in the treatment of glaucoma and intraocular hypertension Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topica... | 04/15/2008 |
| 7335365 | HIV-encoded chemoattractant The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various treatment modes for individuals infected with HIV. The invention furth... | 02/26/2008 |
| 7321046 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediate... | 01/22/2008 |
| RE39991 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation A compound having the following formula: wherein R3 and M are defined herein, and processes therewith. ... | 01/01/2008 |
| 7238816 | Preparation of epothilone derivatives The invention comprises a novel process for the preparation of an epothilone derivative of formula I: wherein R1 and R2 independently from each other represent hydrogen or protecting groups ... | 07/03/2007 |
| 7214705 | Bafilomycin-like metabolite from a novel species The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this metabolite and methods ... | 05/08/2007 |
| 7151116 | Apoptolidin analogs and derivatives for inducing apoptosis in transformed cells The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof; selectively functionalized apoptolidin derivatives and stereoisomers thereo... | 12/19/2006 |
| 7135574 | Process for the preparation of cyclic diketones The present invention relates to a process for the preparation of compounds of formula I wherein the substituents are as defined in claim 1, by conversion of a compound of formula II | 11/14/2006 |
| 7129221 | 6,11-bicyclic erythromycin derivatives The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmace... | 10/31/2006 |
| 7105684 | Lactone compounds An object of the present invention is to provide a novel monomer compound having a lactone structure which gives polymers having more excellent feature as resist material, etc. The present invention relates to a compound represented by the following formula [... | 09/12/2006 |
| 7101654 | Norbornene-type monomers and polymers containing pendent lactone or sultone groups The disclosed invention relates to novel norbornene-type monomers containing pendent lactone or sultone groups. The invention also relates to norbornene-type polymers and copolymers comprising one or more repeating units represented by the formula: | 09/05/2006 |
| 7064110 | 6-11 bicycle ketolide derivatives The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmace... | 06/20/2006 |
| 7026351 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods o... | 04/11/2006 |
| 7026352 | Physiologically active substances The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incuba... | 04/11/2006 |
| 6989450 | Synthesis of epothilones and related analogs The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby t... | 01/24/2006 |
| 6982280 | Epothilone derivatives, a method for the production thereof, and their use The present invention relates to epothilon derivatives, processes for their production and their use in the manufacture of medicaments and plant protection agents. ... | 01/03/2006 |
| 6965034 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates ... | 11/15/2005 |
| 6946482 | Motilide compounds Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditi... | 09/20/2005 |
| 6936402 | MONOMERS CONTAINING AN OXEPAN-2-ONE GROUP, PHOTORESIST COMPOSITIONS COMPRISING POLYMERS PREPARED FROM THE MONOMERS, METHODS FOR PREPARING THE COMPOSITIONS, AND METHODS FOR FORMING PHOTORESIST PATTERNS USING THE COMPOSITIONS Disclosed herein is a novel norbornene, acrylate or methacrylate monomer as a photoresist monomer containing an oxepan-2-one group. Further disclosed are photoresist compositions comprising a polymer prepared from the monomer, methods for preparing the photoresist c... | 08/30/2005 |
| 6927057 | Macrolide analogs Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compoun... | 08/09/2005 |
| 6924079 | Resist resin, chemical amplification type resist, and method of forming of pattern with the same The present invention relates to a resist resin having an acid-decomposable group, which gives rise to decomposition of the acid-decomposable group to show an increased solubility to an aqueous alkali solution by the action of an acid, wherein the resist resin has, ... | 08/02/2005 |
| 6919464 | Synthetic derivatives of 21-butenyl and related spinosyns Macrolide compounds produced by synthetic modification of factors produced by NRRL 30141 have insecticidal and acaricidal activity and are useful intermediates for preparing additional insecticidal and acaricidal compounds ... | 07/19/2005 |
| 6855831 | Process for the preparation of cyclic diketones The present invention relates to a process for the preparation of compounds of formula I: wherein the substituents are as defined in claim 1, by conversion of a compound of formula II: | 02/15/2005 |
| 6828340 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth... | 12/07/2004 |
| 6815463 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ... | 11/09/2004 |
| 6710189 | Method to produce novel polyketides A polyketide, or an antibiotic which is obtainable from the polyketide by a method comprising treating the polyketide with a culture medium conditioned by Saccharopolyspora erythraea, selected from the group consisting of: | 03/23/2004 |
| 6706740 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Heterocyclic aromatic amides (HAA) according to Formula I: wherein X1-X4, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are us... | 03/16/2004 |
| 6670389 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ##STR1##... | 12/30/2003 |
| 6667338 | 9-amino erythromycin derivatives with antibacterial activity Compounds of formula (I) ##STR1## and formula (II) ##STR2## or therapeutically acceptable salts or prodrugs thereof are useful as antibacterial agents. Methods to make the compounds, compositions containing the compounds, and methods of treatment usi... | 12/23/2003 |
| 6660448 | Polymer, resist composition and patterning process The invention provides a polymer comprising recurring units containing bridged aliphatic rings in the backbone and having a hydroxyl, acyloxy or alkoxylcarbonyloxy group as well as a lactone structure bonded through a spacer, the polymer having a weight a... | 12/09/2003 |
| 6656961 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present inve... | 12/02/2003 |
| 6610736 | 16-Halogen-epothilone derivatives, method for producing them and their pharmaceutical use The invention relates to novel epothilone derivatives of general formula (I), wherein R8 means a halogen atom, especially a fluorine or chlorine atom, and the remaining substituents have the meanings given in the description. The novel compound... | 08/26/2003 |
| 6559322 | Process for preparation of a lactone from a cyclic ketone The present invention provides a new biocatalyst whole cell system for converting cyclic ketones such as cyclopentanone/cyclohexanone to the corresponding lactones such as valerolactone/caprolactone. Another novel aspect of the present invention is that b... | 05/06/2003 |
| 6500961 | Lactone compounds having alicyclic structure and their manufacturing method Lactone compounds of formula (1) are useful as monomers to form base resins for use in chemically amplified resist compositions adapted for micropatterning lithography. ##STR1## R1 is H or C1-6 alkyl, R2 is H or an acyl or... | 12/31/2002 |
| 6437151 | Erythromycins and process for their preparation Erythromycins, particularly ones with novel C-13 substituents R1 (e.g. C3 -C6 cycloalkyl or cycloalkenyl groups) are prepared by fermenting suitable organisms in the presence of R1 CO2 H. A preferred organism is... | 08/20/2002 |
