Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7378534 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect. ... | 05/27/2008 |
| 7358053 | Methods for detecting and reversing resistance to macrocyclic lactone compounds This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The in... | 04/15/2008 |
| 7316884 | 5-methylene-1,3-dioxolan-4-one derivatives, process for their production, polymers of the derivatives, resist compositions, and pattern formation process A 5-methylene-1,3-dioxolan-4-one derivative and a monomer and copolymer thereof and a resist composition containing the polymer or copolymer where the 5-methylene-1,3 -dioxolan-4-one derivative is of formula (1): ... | 01/08/2008 |
| 7314942 | Methylenelactones syntheses in supercritical fluids Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid. ... | 01/01/2008 |
| 7232915 | Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe... | 06/19/2007 |
| 7230027 | Anti-first-pass effect compounds Compositions, methods, etc. for addressing the first-pass effect. ... | 06/12/2007 |
| 6995187 | Peripheral cannabinoid receptor (CB2) selective ligands Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals for treatment of ... | 02/07/2006 |
| 6927057 | Macrolide analogs Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compoun... | 08/09/2005 |
| 6808724 | Artemisolide compound isolated from the aerial parts of Artemisia sylvatica, isolation method, and use thereof The present invention relates to a novel compound isolated from Artemisia Sylvatica, expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel compound isolated from Artemisia Sylvatica, a method of isolat... | 10/26/2004 |
| 6716832 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I): in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenalkyl,... | 04/06/2004 |
| 6693092 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) ##STR1## in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalke... | 02/17/2004 |
| 6660766 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.... | 12/09/2003 |
| 6605595 | Avermectin derivatives Avermectin derivatives represented by the general formula (I) or salts thereof: ##STR1## wherein --X----Y-- represents --CH.dbd.CH--, --CH2 --C(.dbd.O)--, --CH2 --CH2 --, or --CH2 --CH(R13)--; for exa... | 08/12/2003 |
| 6500960 | Method to produce novel polyketides Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of the formula ##STR1## wherein A is a moiety that a... | 12/31/2002 |
| 6486195 | Thermodynamically stable crystal form of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation The most thermodynamically stable crystalline form of the benzoic acid salt of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.... | 11/26/2002 |
| 6476066 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for inhibiting the first pass effect.... | 11/05/2002 |
| 6410590 | Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel derivatives of Andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of Andrographolide have the genera... | 06/25/2002 |
| 6387948 | 8-Acetylarteminolide and process for preparing same 8-Acetylarteminolide of the formula (I) having inhibitory activities against farnesyl-protein transferase(FPTase), a progression of the cell cycle and angiogenesis may be useful for the prevention and treatment of various cancers and angiogenesis-related ... | 05/14/2002 |
| 6388099 | Production of 8,8a-dihydroxy-6-deoxyerythronolide B The heterologous expression of the OlePKS in Streptomyces lividans, produces 8,8a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with DEBS in S. lividans of the P450 monooxygenase OleP produces 8,8a-dihydroxy-6-deoxyerythonolid... | 05/14/2002 |
| 6372781 | Compounds for treating gastroduodenal diseases Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1 -C5) alkyl or CH3 (CH2)n CO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal... | 04/16/2002 |
| 6362168 | Antiparasitic agents Compounds of the formula: ##STR1## wherein X represents a single or a double bond; R1 is H or OH; provided that when X is a single bond, R1 is H or OH, and when X is a double bond, R1 is absent; R2 is H, C1... | 03/26/2002 |
| 6355810 | Multibinding inhibitors of HMG-CoA reductase Disclosed are multibinding compounds which inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-COA reductase), the rate limiting enzyme in cholesterol biosynthesis. The multibinding compounds of this invention containing from 2 to 10 ligands cova... | 03/12/2002 |
| 6355441 | Benzothiazole dioxetanes Chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature, represented by the formulas I or II: ##STR1##... | 03/12/2002 |
| 6309687 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.... | 10/30/2001 |
| 6281361 | Dibenzonaphthyrones Dibenzonaphthyrone of formula (I) ##STR1## wherein A1 and A2 independently of each other are unsubstituted or mono- to tetra-substituted o-C6 -C18 arylene, with the proviso that formula (I) does not represent a ... | 08/28/2001 |
| 6255337 | Anti-first-pass effect compounds and citrus extract First-pass effective substances derived from citrus.... | 07/03/2001 |
| 6248776 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for inhibiting the first pass effect.... | 06/19/2001 |
| 6239073 | Brassinosteroid analogs useful as plant growth regulators Disclosed are compositions and methods for promoting plant growth. The compounds are cyclopropyl-, cyclobutyl-, and cyclopentyl-substituted brassinosteroids having high growth promoting ability. They may be used alone or in combination with other plant gr... | 05/29/2001 |
| 6174710 | Spirolaxine derivatives for treating gastrobuodenal diseases Spirolaxine, the compound of formula (I) ##STR1## wherein R is H, and the novel compounds of formula (I) wherein R is (C1 -C6)alkyl or CH3 (CH2)n CO and n is 1, 2, 3 or 4 are useful in treating gastro... | 01/16/2001 |
| 6124477 | Anti-first-pass effect compounds The present inventor has discovered chemical compounds which inhibit the first-pass effect of orally administered drugs in humans; that phototoxic low molecular weight furocoumarins and certain ether-substituted furocoumarins that are naturally present in... | 09/26/2000 |
| 6063809 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.... | 05/16/2000 |
| 6054477 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.... | 04/25/2000 |
| 5989566 | Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solve... | 11/23/1999 |
| 5990154 | Anti-first-pass effect compounds and citrus extract This invention relates to the process of making citrus (preferably grapefruit) extract having reduced levels of phototoxic furocoumarins and containing enhanced amounts of one or more anti-first pass effect compounds.... | 11/23/1999 |
| 5962659 | Anthelmintic milbemycins and avermectins Novel compounds of formula (I): ##STR1## wherein R1 is hydrogen or optionally protected hydroxy; R2 is alkoxy, optionally protected hydroxy, oxo or optionally O-substituted oximino; R3 is hydrogen, optionally protecte... | 10/05/1999 |
| 5883080 | Antiparastic auermectin derivatives Antiparasitic avermectin derivatives of formula (I), where the broken line represents an optional bond, R1 and R4 are independently H, OH, halo, oximino, or an organic radical, R2, R6 and R7 are organ... | 03/16/1999 |
| 5871938 | Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore 1,2-dioxetane compounds bearing a proteolytic enzyme specific amino acid or peptide are provided, which amino acid or peptide can be removed by action of the corresponding protease. When the amino acid or peptide is removed, the 1,2-dioxetane decomposes w... | 02/16/1999 |
| 5861518 | Phthalide compounds and their production process This invention provides processes for producing phthalide compounds which comprise cultivating Phanerochaete avelutina FERM BP-4787 and then isolating phthalide compounds from the fermentation broth.... | 01/19/1999 |
| 5861429 | 13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests Compounds of formula (I): ##STR1## wherein: R1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is .dbd.C.dbd.(R2)2 or .dbd.C.dbd.(CH2)m, in which R2 is alkyl, a... | 01/19/1999 |
| 5843681 | Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore 1, 2-dioxetane compounds bearing a proteolytic enzyme specific amino acid or peptide are provided, which amino acid or peptide can be removed by action of the corresponding protease. When the amino acid or peptide is removed, the 1,2-dioxetane decomposes ... | 12/01/1998 |
