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Class 549/263 - Lactones (i.e., -C(=X)O-, wherein X is chalcogen, is part of the hetero ring)


Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the hetero ring is a lactone, i.e., a
No. of patents: 110
Last issue date: 02/28/2012


1      
NumberTitleIssue Date
8124794Method for the asymmetric synthesis of beta-lactone compounds
The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inh...
02/28/2012
7728153Method for the asymmetric synthesis of beta-lactone compounds
The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inh...
06/01/2010
7425519Liquid phase oxygenation reaction using tungsten species
The present invention is to provide a method by which, in carrying out a liquid-phase oxidation reaction using a catalyst comprising a tungsten species as an essential component, the catalytic activity performance can be improved or maintained and by which the catal...
09/16/2008
7417029Prodrug of an ice inhibitor
This invention describes an ICE inhibitor prodrug (I) having good bioavailability Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerativ...
08/26/2008
7414139Catalytic antioxidants and methods of use
The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some em...
08/19/2008
7387805Flavonoid solubilizion agent and method of solubilizing flavonoid
A flavonoid solubilization agent capable of highly solubilizing flavonoids such as isoflavone, baicalin, rutin and naringin whose solubility is generally low; and a method of effecting the above solubilization. Flavonoids can be solubilized by causing a flavonoid an...
06/17/2008
7358275Internal 1,15-lactones of fluprostenol and related prostaglandin F2a analogs and their use in the treatment of glaucoma and intraocular hypertension
Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topica...
04/15/2008
73168845-methylene-1,3-dioxolan-4-one derivatives, process for their production, polymers of the derivatives, resist compositions, and pattern formation process
A 5-methylene-1,3-dioxolan-4-one derivative and a monomer and copolymer thereof and a resist composition containing the polymer or copolymer where the 5-methylene-1,3 -dioxolan-4-one derivative is of formula (1): ...
01/08/2008
7314942Methylenelactones syntheses in supercritical fluids
Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid. ...
01/01/2008
7220357Method of purifying macrolides
Provided is a method of purifying a macrolide, especially tacrolimus, that includes loading macrolide onto a bed of sorption resin and elting with a suitable eluent such as a combination of water and tetrahydrofuran. ...
05/22/2007
7208634Oxidation method of primary or secondary alcohol
A method for preparing an aldehyde or ketone by oxidizing a primary or secondary alcohol in the presence of a nitroxyl radical compound and a co-oxidant in an organic solvent, which process is characterized in using an organic N-bromoamide compound or a combination ...
04/24/2007
7205416Liquid phase synthesis of methylene lactones using novel grafted catalyst
Process for converting certain lactones to their alpha-methylene substituted forms that exhibits high conversion and selectivity. ...
04/17/2007
7199254Liquid phase synthesis of methylene lactones using novel catalyst
Process for converting certain lactones to their alpha-methylene derivatives in the liquid phase with both high conversion and selectivity using easily recoverable novel heterogeneous catalysts. ...
04/03/2007
7193041Method for purification of recombinant proteins
Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2+ and a coordination number of 6. A method for syn...
03/20/2007
7192982Modulators of peroxisome proliferator activated receptors
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or uns...
03/20/2007
7166727Supercritical fluid phase synthesis of methylene lactones using novel grafted catalyst
Process for converting certain lactones to their alpha-methylene substituted forms in a supercritical or near-critical fluid phase reaction using a novel grafted catalyst that not only exhibits high initial activity (conversion), but also maintains a high level of a...
01/23/2007
7164033Gas phase synthesis of methylene lactones using novel catalyst
Process for converting certain lactones to their alpha-methylene substituted forms that not only exhibits high initial activity (conversion), but also maintains a high level of activity with time on stream. ...
01/16/2007
7164032Supercritical fluid phase synthesis of methylene lactones using novel catalyst field of invention
Process for converting certain lactones to their alpha-methylene substituted forms that not only exhibits high initial activity (conversion), but also provides high reactor productivity (mass of product per mass of catalyst per unit of time) and sustained maintenanc...
01/16/2007
7161014Gas phase synthesis of methylene lactones using novel grafted catalyst
Process for converting certain lactones to their alpha-methylene substituted forms that not only exhibits high initial activity (conversion), but also maintains a high level of activity with time on stream. ...
01/09/2007
7153981Supercritical fluid phase synthesis of methylene lactones using oxynitride catalyst
Process for converting certain lactones to their alpha-methylene substituted forms in a supercritical or near-critical fluid phase reaction using an oxynitride catalyst or a composite oxynitride catalyst incorporating lithium, sodium, potassium, rubidium, cesium, ma...
12/26/2006
7151185Gas phase synthesis of methylene lactones using oxynitride catalyst
Process for converting certain lactones to their alpha-methylene substituted forms using an oxynitride catalyst or a composite oxynitride catalyst incorporating lithium, sodium, potassium, rubidium, cesium, magnesium, calcium, strontium, or barium or combinations th...
12/19/2006
7141682Liquid phase synthesis of methylene lactones using oxnitride catalyst
Process for converting certain lactones to their alpha-methylene derivatives in the liquid phase using oxynitride catalysts or composite catalysts incorporating dithium, sodium, potassium, rubidium, cesium, magnesium, calcium, strontium, or barium or combinations th...
11/28/2006
7141602Process for obtaining HMG-CoA reductase inhibitors of high purity
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of d...
11/28/2006
7074431Process for preparing a pharmaceutical composition
A method for the preparation of compositions, preferably pharmaceutical compositions, in form of expanded, mechanically stable, lamellar, porous, sponge-like or foam structures out of solutions and dispersions results in a favored pharmaceutical product. This method...
07/11/2006
7057077Method for producing 2- (alkyl) cycloalkenone
A method for producing 2-(alkyl)cycloalkenone and a method for producing alkyl(3-oxo-2-alkylcycloalkyl) acetate and 5-alkyl-5-alkanolide which are useful as flavoring materials and physiologically active substances using the same are provided. A method for producing...
06/06/2006
7052671Storage, generation, and use of hydrogen
A composition comprising a carrier liquid; a dispersant; and a chemical hydride. The composition can be used in a hydrogen generator to generate hydrogen for use, e.g., as a fuel. A regenerator recovers elemental metal from byproducts of the hydrogen generation proc...
05/30/2006
7030279Process for transition metal free catalytic aerobic oxidation of alcohols under mild conditions using stable free nitroxyl radicals
An alcohol can be oxidized by a process in which a primary or secondary alcohol are reacted with an oxygen-containing gas in the presence of a catalyst composition containing (i) a stable free nitroxyl radical derivative, (ii) a nitrate source, (iii) a bromide sourc...
04/18/2006
6974806Lipid-rich plaque inhibitors
The present invention provides a lipid-rich plaque regressing agent comprising a compound represented by Formula: in which ring A is a cyclic hydrocarbon or the like; ring B is a heterocyclic ring or the like; each of ...
12/13/2005
6958405Polymer-encapsulated titanium zeolites for oxidation reactions
Catalysts useful for oxidation reactions are disclosed. The catalysts comprise a polymer-encapsulated titanium zeolite. The catalysts are easy to prepare and use, they are easy to recover and reuse, and they provide good conversions in a variety of important oxidati...
10/25/2005
6949536Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ...
09/27/2005
6906051Lactone integrin antagonists
The present invention relates to a class of compounds represented by the Formula I: or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selec...
06/14/2005
6881341Method for separating lactone-containing high-molecular weight compounds
A method for separating a lactone-containing high-molecular weight compound comprising subjecting a mixture of a lactone-containing high-molecular weight compound having, as its side-chain, at least one of a lower alkenyl group and a lower alkoxy group and its analo...
04/19/2005
6818638Melvinolin derivatives
Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions. ...
11/16/2004
6808724Artemisolide compound isolated from the aerial parts of Artemisia sylvatica, isolation method, and use thereof
The present invention relates to a novel compound isolated from Artemisia Sylvatica, expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel compound isolated from Artemisia Sylvatica, a method of isolat...
10/26/2004
6746818(Meth)acrylates having lactone structure, polymers, photoresist compositions and patterning process
(Meth)acrylate compounds having a norbornane, bicyclo[2.2.2]octane, 7-oxanorbornane or cyclohexane ring structure and a γ-butyrolactone ring structure connected together by a suitable linker are novel and useful in forming polymers having high transparency, especia...
06/08/2004
6734314Preparation of orlistat and orlistat crystalline forms
The present invention is directed to a process of converting lipstatin to orlistat by catalytic hydrogenation. The present invention further discloses novel crystalline solid orlistat forms, designated form I and form II and methods for their preparation. ...
05/11/2004
6727238Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi...
04/27/2004
6720327Lactone integrin antagonists
The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selecti...
04/13/2004
6720302Method for preparing a γ-unsaturated β-lactone and use thereof as an aromatic and flavouring ingredient
(6R)-4,5,6,7-Tetrahydro 3,6-dimethyl-3H-benzo[b]furan-2-one is a compound of use in perfumery and the field of flavorings. The compound can be used to impart a minty, slightly vanilla-scented odor, and its flavor imparts sweetness and roundness to the compositions t...
04/13/2004
6716832Arylphenyl-substituted cyclic ketoenols
The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I): in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenalkyl,...
04/06/2004
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