Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7501529 | 7-Ethynyl-2,4,9-trithiaadamantane and related methods 7-ethynyl-2,4,9-trithiaadamantane and related methods are presented. Manufacturing 7-ethynyl-2,4,9-trithiaadamantane includes the steps of: (1) reducing alkyl 2,4,9-trithiaadamantane-7-carboxylate to produce 7-hydroxymethyl-2,4,9-trithiaadamantane; (2) oxidizing 7-h... | 03/10/2009 |
| 7301705 | Alicyclic compound for optical material The alicyclic compound of the present invention has a five- or more membered ring structure having an epithioethylene linkage and/or an epidithioethylene linkage, and has tow or more sulfur atoms in its molecule. Optical materials produced by curing the alicyclic co... | 11/27/2007 |
| 7294723 | Multifunctional cationic photoinitiators, their preparation and use Compounds of formula (I): [where: R1 is a direct bond, oxygen, a group >CH2, sulphur, a group >C═O, a group-(CH2)2— or a group-N—Ra, where Ra is hydrogen or alkyl; R3, R4, ... | 11/13/2007 |
| 7176317 | Colorant compounds Compounds of the formula wherein R1, R2, R3, R4, R5, R6, R7, a, b, c, d, Y, Q, Q—, A, and CA are as defined herein. ... | 02/13/2007 |
| 7169520 | Organophotoreceptor with charge transport material with a hydrazone group linked to a heterocyclic group Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 01/30/2007 |
| 7160732 | Fluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... | 01/09/2007 |
| 7101998 | Fused ring compounds, and their use as cationic photoinitiators Compounds of formula (I): [in which: R1 represents a direct bond, an oxygen atom, a group >CH2, a sulphur atom, a group >C═O, a group —(CH2)2— or a group of formu... | 09/05/2006 |
| 7094910 | Bridged diarylpolymethine chromophores An infrared dye, characterised in that the dye comprises two bridged diarylpolymethine type dyes or derivatives thereof connected together at either the 3, 4, 5 or 6 position by a central moiety such that the two dyes are located on each side of the central moiety, ... | 08/22/2006 |
| 7087765 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 08/08/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6894177 | Intermediate compounds of non-nucleoside reverse transcriptase inhibitors Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative... | 05/17/2005 |
| 6806283 | Selective serotonin receptor antagonists and therapeutic applications thereof Spiro[9,10-dihydroanthracene]-9,3′-pyrrolidine (SPAN) and derivatives thereof are provided as selective serotonin receptor antagonists. The compounds are selective, high affinity antagonists of 5-HT2 serotonin receptors. The compounds are useful as anti... | 10/19/2004 |
| 6784202 | Cubane derivatives as metabotropic glutamate receptor agonists or antagonists and process for their preparation The present invention relates to therapeutically active cubane compounds, a method of preparing the same, and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases of the central nervous system related to the me... | 08/31/2004 |
| 6750244 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 06/15/2004 |
| 6696569 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C--C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence by reaction with a peroxidase enz... | 02/24/2004 |
| 6693136 | Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors Compounds of formula (I) ##STR1## are novel P2X3 and P2X2 /P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.... | 02/17/2004 |
| 6638713 | Optical molecular sensors for cytochrome P450 activity The invention provides methods of using a compound as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and kits for performing these methods. The optical probe ... | 10/28/2003 |
| 6635437 | Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing he... | 10/21/2003 |
| 6420130 | Optical molecular sensors for cytochrome P450 activity The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe... | 07/16/2002 |
| 6407137 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 06/18/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6342605 | Valeraldehyde and process for its preparation Bidentate phosphine ligands of the formula ##STR1## wherein the substituents are as defined in the specification and a process for preparing linear aldehydes by hydroformylating internal olefins using such phosphine ligands.... | 01/29/2002 |
| 6300339 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein A, B, Q, T, X, Y, Z, R5, R6, R7, R8, Ar, k, m, n and p are as defined in the specification. These compounds are useful in treating or pr... | 10/09/2001 |
| 6258836 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 07/10/2001 |
| 6211385 | Process for preparing substituted benzo[1,2-G]-chrome-3-ene, benzo[1,2-G]-thiochrom-3-ene and benzo[1,2-G]-1,2-dihydroquinoline derivatives Compounds of Formula 1 ##STR1## where the symbols have the meaning disclosed in the specification are prepared by reaction of a compound of Formula 2 ##STR2## with an organometal reagent R--M to provide a compound of Formula 3 ##STR3## that is reacte... | 04/03/2001 |
| 6172058 | Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cyclo... | 01/09/2001 |
| 6127415 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especiall... | 10/03/2000 |
| 6124484 | Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis The present invention provides a method for the preparation of triarylmethyl protecting group reagents. The reagents are prepared from reaction effluent from the cleavage step of oligonucleotide synthetic regimes.... | 09/26/2000 |
| 6054474 | Heterocyclic compounds for the treatment of pain and use thereof Polycyclic alkaloids of formula (I), ##STR1## wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH... | 04/25/2000 |
| 6054448 | 2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R1 is Y or Y--C1-6 alkyl, where Y is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' ... | 04/25/2000 |
| 6022307 | Substituted dibenzothiophenes having antiangiogenic activity The invention provides novel substituted dibenzothiophenes of Formulae (I), (II), (III) and (IV) which have antiangiogenic activity and further provides a method using substituted dibenzothiophenes of Formula (V) as antiangiogenic agents.... | 02/08/2000 |
| 5994392 | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 11/30/1999 |
| 5990104 | Polycyclic alcaloid-derivatives as NMDA-receptor antagonists Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH)--NH2, ... | 11/23/1999 |
| 5985799 | Tricyclic herbicidal heterocycles Compounds of Formula (I), and their N-oxides and agriculturally-suitable salts, are disclosed which are useful in controlling undesired vegetation, wherein J is Formula (II), Q is represented by Q-1 through Q-4 and X, Y, Z, R1-19, m, n, p, q, a... | 11/16/1999 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
| 5891899 | Pharmaceutical xanthene compounds A pharmaceutical compound of the formula: ##STR1## in which A is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OPO(OH)OR' B is a bond, C1-6 alkylene or C2-6 ... | 04/06/1999 |
| 5728846 | Benzo1,2-g!-chrom-3-ene and benzo1,2-g!-thiochrom-3-ene derivatives Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist and/or retinoid inverse-agonist-like biological activity.... | 03/17/1998 |
| 5726208 | Heterocyclic tertiary amines New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers, and their addition salts with pharmaceutically acceptable acids. Those compounds may be used as med... | 03/10/1998 |
| 5721260 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts therefor, to methods for their preparation, to compositions containing the... | 02/24/1998 |
| 5679805 | Photochromic spironaphthopyran compounds A naphthopyran compound represented by the formula: ##STR1## wherein A and B are each selected from the following group: a substituted divalent cyclic radical, a substituted divalent aromatic radical, and a substituted divalent fused heterocyclic rad... | 10/21/1997 |
