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| Number | Title | Issue Date |
| 7601851 | Compounds and methods for fluorescent labeling Dye reagents useful in labeling biological materials are provided along with methods for their use. ... | 10/13/2009 |
| 7524974 | Fluorescent probe A fluorescent probe which is represented by the following formula (I): (wherein, R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species, or th... | 04/28/2009 |
| 7408072 | Heteropolycyclic compound and dye The present invention provides heteropolycyclic compounds represented by General Formulae (1) and (2): wherein R1 is a straight- or branched-chain C1-C10 alkyl group or the like; R2 | 08/05/2008 |
| 7399854 | Regents labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 07/15/2008 |
| 7256275 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... | 08/14/2007 |
| 7179906 | Asymmetric benzoxanthene dyes A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R | 02/20/2007 |
| 7163909 | Authenticity indicator A rapidly reversing authenticity indicator for substrates such as secure documents, tags and labels is described. The authenticity indicator comprises a substrate having provided thereon a coating of a colorless chromogenic material, a binder material and optional p... | 01/16/2007 |
| 7038063 | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrates. Methods... | 05/02/2006 |
| 6967250 | Energy transfer dyes Energy transfer dyes, their preparation, and their use as labels in biological systems is disclosed. The dyes are preferably in the form of cassettes which enable their attachment to a variety of biological materials. The dyes and the reagents that can be made from ... | 11/22/2005 |
| 6916925 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds arc useful, inter alia, for determining the binding and/or receptor sites of the molecules. ... | 07/12/2005 |
| 6649769 | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrat... | 11/18/2003 |
| 6635602 | Preparation process for manufacture and purification of mixtures of fluoran compounds and recording material comprising said mixtures of fluoran compounds A process for the manufacture of mixtures of fluoran compounds by the reaction of keto acids of formula (II) with a compound of formula (III) in the presence of a dehydrating condensation agent, wherein R1 and R2 independently represent hydrogen; an alkyl... | 10/21/2003 |
| 6632933 | Use of azetidinone compounds The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These co... | 10/14/2003 |
| 6630588 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.... | 10/07/2003 |
| 6617445 | Asymmetric benzoxanthene dye labelling reagents A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R1 -R8 are hydrog... | 09/09/2003 |
| 6608213 | Fluorescence-labeled probe for DNA and a fluorescence-labeled plasmid This invention provides a precursor compound of a novel fluorescence-labeled probe for DNA, prepared by covalent binding of a fluorescent substance such as fluorescein isothiocyanate, wherein a conjugating group was bounded, with aminoalkylate phenylamine... | 08/19/2003 |
| 6569892 | Diaminofluorescein derivatives A compound represented by the following formula: ##STR1## wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C | 05/27/2003 |
| 6566302 | Monophase solid solutions comprising a plurality of color former compounds and process for their preparation A monophase solid solution comprising a plurality of color formers selected from the group consisting essentially of the fluoran type, phthalide type, phenoxazine type, phenothiazine type, rhodamine lactam type, leuco-auramine type, triphenylmethane type,... | 05/20/2003 |
| 6482938 | Compounds having energy transfer function and method for DNA base sequencing by using the same Disclosed are compounds having two kinds of reporters that can be a donor and an acceptor for energy transfer, for example, fluorescent groups, and having a 2', 3'-dideoxyribonucleotide residue or a 3'-deoxyribonucleotide residue. These compounds can be u... | 11/19/2002 |
| 6448407 | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis Substantially pure atropisomers of xanthene compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and c... | 09/10/2002 |
| 6441197 | Diaminofluorescein derivative A compound represented by the following formula (I): ##STR1## wherein R1 and R2 represent amino group that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono... | 08/27/2002 |
| 6403812 | 4, 7-Dichlorofluorescein dyes as molecular probes Long wavelength, narrow emission bandwidth fluorecein dyes are provided for detecting spacially overlapping target substances. The dyes comprise 4,7-dichlorofluoresceins, and particularly 2',4',5',7'-tetrachloro-4,7-dicloro-5- (and 6-) carboxyfluoresceins... | 06/11/2002 |
| 6376669 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.... | 04/23/2002 |
| 6346536 | Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same Poly(ADP-ribose) polymerase ("PARP") inhibitors and methods for treating neurodegenerative diseases, neural tissue damage related to cerebral ischemia and reperfusion injury, and cardiovascular in an animal.... | 02/12/2002 |
| 6303775 | Polynucleotides labelled with asymmetric benzoxanthene dyes A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R1 -R8 are hydrog... | 10/16/2001 |
| 6162931 | Fluorinated xanthene derivatives The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes... | 12/19/2000 |
| 6140513 | Color forming dye precursor, composition containing the same and color forming heat-sensitive recording material Provided is an electron donating dye precursor represented by the following formula (1), (2), (3) or (4) as defined in the specification which each singly develops two colors upon color forming reaction with one kind of an electron accepting color develop... | 10/31/2000 |
| 6071853 | Crystalline fluoran compound Disclosed are a novel crystal form of the fluoran compound represented by formula (I) as characterised by specific X-ray powder diffraction pattern and melting range; process for the preparation of said novel crystal form and recording materials comprisin... | 06/06/2000 |
| 6020481 | Asymmetric benzoxanthene dyes A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y1 and Y2 are individually hydroxyl amino, imminium, or oxygen, R1 -R8 are hy... | 02/01/2000 |
| 6008379 | Aromatic-substituted xanthene dyes A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having the general structure where Y1 and Y2 taken separately are selected from the group consisting of hydroxyl, oxygen, immin... | 12/28/1999 |
| 5846737 | Conjugates of sulforhodamine fluorophores with enhanced fluorescence The invention describes useful conjugates of sulforhodamine, wherein the conjugated substance and the fluorophore are separated by an alkanoic acid spacer that is attached to the fluorophore via a sulfonamide bond. The increased length of the covalent lin... | 12/08/1998 |
| 5623080 | Fluorone and pyronin Y derivatives A compound of the formula (I) or (II): ##STR1## where R1, R2, R5 and R6 are the same or different and represent a hydrogen atom or a halogen atom and R1 and R2 may combine to form a ri... | 04/22/1997 |
| 5616729 | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers Triggerable dioxetanes with a fluorescent substituent bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are of the formula: ##STR1## wherein R1, R2 and R3 ar... | 04/01/1997 |
| 5516864 | Fluorescent ion-selective diaryldiaza crown ether conjugates This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous ... | 05/14/1996 |
| 5324704 | Fluoran compounds, crystalline toluene adducts thereof, recording material comprising same and process for their preparation Disclosed are novel fluoran compounds represented by the formula (I): ##STR1## wherein R1 and R2 are different groups selected from cyclohexyl, n-butyl and isobutyl, e.g., in the form of crystals characterized by a specific X-ra... | 06/28/1994 |
| 5315015 | Compounds having improved fluorescence in fluorescence polarization immunoassays and immunoassays utilizing same Compounds of the formula ##STR1## wherein F is a fluorescing compound; Y is --NH-- or a single covalent bond; Z is a straight or branched alkylene chain of 2 to 10 carbon atoms which is substituted by at least one hydrophilic group; Q is oxygen or ... | 05/24/1994 |
| 5231069 | Fluoran compound, heat sensitive recording materials comprising fluoran compound Heat-sensitive recording paper which employs as a chromogenic compound a novel fluoran compound represented by the formula: ##STR1## and prepared reacting a benzoic acid derivative of the formula: ##STR2## with a diphenylamine derivative of the ... | 07/27/1993 |
| 5220038 | Fluoran compounds, crystalline toluene adducts thereof, recording material comprising same and process for their preparation Disclosed are novel fluoran compounds represented by the formula (I): ##STR1## wherein R1 and R2 are different groups selected from cyclohexyl, n-butyl and isobutyl, e.g., in the form of crystals characterized by a specific X-ra... | 06/15/1993 |
| 5194632 | Fluoran compound, useful in heat sensitive recording materials Disclosed are a novel fluoran compound represented by the formula (I): ##STR1## and a heat-sensitive recording paper which is obtained by using the fluoran compound as a chromogenic compound and is excellent in preserving stability.... | 03/16/1993 |
| 5188934 | 4,7-dichlorofluorescein dyes as molecular probes Long wavelength, narrow emission bandwidth fluorecein dyes are provided for detecting spacially overlapping target substances. The dyes comprise 4,7-dichlorofluoresceins, and particularly 1',2',7',8'-dibenzo-4,7-dichlorofluoresceins. Methods of using the ... | 02/23/1993 |
