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| Number | Title | Issue Date |
| 7985865 | Phase change ink formulations, colorant formulations, and methods of forming colorants A compound having the formula wherein R1, Z, and the carbonyl can be comprised by a common ring, wherein R1 comprises a chromophore that absorbs light from the visible wavelength range, and wherein n i... | 07/26/2011 |
| 7982056 | Substantially pure fluorescein The present invention is directed to an improved process for producing substantially pure fluorescein, as well as to substantially pure fluorescein compositions prepared by the process. The invention is particularly directed to the provision of pharmaceutical compos... | 07/19/2011 |
| 7939678 | Phase change ink formulations, colorant formulations, and methods of forming colorants A compound having the formula wherein R1, Z, and the carbonyl can be comprised by a common ring, wherein R1 comprises a chromophore that absorbs light from the visible wavelength range, and wherein n i... | 05/10/2011 |
| 7820833 | Dithio compounds Disclosed herein are dithio compounds that include at least one fluorophore. The compounds additionally may include a different fluorophore or a non-fluorophore. The dithio compounds may be used as reagents for detecting thiol-containing compounds. ... | 10/26/2010 |
| 7767834 | Phosphonylated fluorescent dyes and conjugates Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates. ... | 08/03/2010 |
| 7671218 | Phosphonate fluorescent dyes and conjugates Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates. ... | 03/02/2010 |
| 7642362 | Compounds as semaphorin inhibitors Compounds represented by the general formula (1) wherein R1 and R3 are each independently hydrogen or a carboxyl group and R2 and R4 are each independently hydrogen or a hydroxyl ... | 01/05/2010 |
| 7534902 | Fluorescence assays with improved sensitivity Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such ... | 05/19/2009 |
| 7491832 | Sulfonate compound and fluorescent probe using the same The present invention provides a sulfonate compound including a structure represented by a general formula (I) below. In the formula (I), an atomic group A-O is an atomic group that forms a fluorescent compound upon cleavag... | 02/17/2009 |
| 7465814 | Sulfonate compound and fluorescent probe using the same The present invention provides a sulfonate compound, including a structure represented by a general formula (I) below, where, in the formula (I), an atomic group A-O is an atomic group that forms a ... | 12/16/2008 |
| 7399854 | Regents labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 07/15/2008 |
| 7399639 | Sensors, and methods of making and using the same The present invention is directed, in part, to sensors for detecting metal ions, and methods of making and using the same. ... | 07/15/2008 |
| 7367994 | Composition for dyeing keratin fibers, comprising a sulfonamidoxanthene direct dye, and dyeing process using the same The present invention relates to a composition for dyeing keratin fibers, in particular human keratin fibers and more particularly the hair, which comprises at least one compound chosen from direct dyes of sulfonamidoxanthene type, in other words sulfonamide derivat... | 05/06/2008 |
| 7282246 | Fluorinated xanthenes and use thereof in liquid-crystal mixtures Concerning the compound of the formula (I) R1, R3 are each independently, for example, H R2, R4 are each independently, for ex... | 10/16/2007 |
| 7279264 | Dyes and use thereof in thermal imaging members and methods There are described novel fluorescein dye compounds and imaging members and imaging methods utilizing the compounds. The fluorescein dye compounds exhibit a first color when in the crystalline form and a second color, different from the first color, when in the liqu... | 10/09/2007 |
| 7279585 | Lipophilic electrophoretic probes Compounds, compositions, and methods for labeling membranes are disclosed. Compounds of formula G-L-E are described wherein G is a lipophilic group, L is a cleavable linkage and E is an electrophoretic group. The compounds become associated with membranes, and can b... | 10/09/2007 |
| 7235675 | Conjugates of mycophenolic acid The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or olig... | 06/26/2007 |
| 7223553 | Immunoassays for everolimus Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided. ... | 05/29/2007 |
| 7200254 | Probe reactive chip, sample analysis apparatus, and method thereof Technology is disclosed for highly accurate automated execution of processing for alignment of a detection area to a DNA microarray image file and processing for quantitative determination of success/failure of the alignment during DNA microarray analysis. A probe r... | 04/03/2007 |
| 7179906 | Asymmetric benzoxanthene dyes A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R | 02/20/2007 |
| 7173125 | Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligon... | 02/06/2007 |
| 7169939 | Energy transfer dyes with enhanced fluorescence Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 01/30/2007 |
| 7160732 | Fluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... | 01/09/2007 |
| 7150967 | Fluorescent tags for amino acid and nucleic acid analysis Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are highly reactive with thiol containing species are provided. Fluoresce... | 12/19/2006 |
| 7132231 | Fluorescence polarization method for determining viral inhibitors Methods for determining inhibitors of protein interactions are provided. The method involves evaluation of potential inhibitors that can inhibit or prevent protein interactions. The method provides for high-throughput identification of novel therapeutics that can tr... | 11/07/2006 |
| 7102024 | Functional biopolymer modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides a... | 09/05/2006 |
| 7087766 | Reagents for the quantitation of active oxygen A compound represented by general formula (I) or (II) or a salt thereof and an agent for measurement of a reactive oxygen comprising said compound or a salt thereof: wherein R1 and R2 independently rep... | 08/08/2006 |
| 7049073 | Double stranded nucleic acid biochips This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector... | 05/23/2006 |
| 7026166 | Fluorogenic dyes The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule. ... | 04/11/2006 |
| 7018840 | Fluorescent metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescent metal sensors for detecting metal ions, and methods of making and using the same. ... | 03/28/2006 |
| 6989446 | Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula V wherein ... | 01/24/2006 |
| 6967250 | Energy transfer dyes Energy transfer dyes, their preparation, and their use as labels in biological systems is disclosed. The dyes are preferably in the form of cassettes which enable their attachment to a variety of biological materials. The dyes and the reagents that can be made from ... | 11/22/2005 |
| 6956695 | System and method for increasing the contrast of an image produced by an epifluorescence microscope The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objecti... | 10/18/2005 |
| 6951952 | Dyes There are described novel rhodol dye compounds The dye compounds exhibit a first color when in the crystalline form and a second color, different from the first color, when in the liquid, amorphous form. ... | 10/04/2005 |
| 6946547 | Ecstasy-class analogs and use of same in detection of ecstasy-class compounds The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class drugs. These analogs are compounds, or salts thereof, of a 2-amino-methyle... | 09/20/2005 |
| 6916608 | Composition for providing long term stability to cells for diagnostic testing The present invention relates to a method and composition for stabilizing clinical specimens (i.e., cells in biological samples) for transport and subsequent testing for diagnosis. The composition is specifically capable of maintaining nucleic acid in the cells inta... | 07/12/2005 |
| 6849745 | Energy transfer dyes with enhanced fluorescence Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 02/01/2005 |
| 6800765 | Fluorescent pH indicators for intracellular assays Systems, including compositions and methods, for measuring pH, particularly in cells, organelles, and other samples. The compositions include pH-sensitive fluorescent and fluorogenic 2′,7′-dialkylfluorescein derivatives and associated nonfluorescent precursor co... | 10/05/2004 |
| 6797479 | Reagents and methods for the detection and quantification of vancomycin in biological fluids Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of FIG. 6 wherein P is an immunogenic carrier material and X is a linking moiet... | 09/28/2004 |
| 6649769 | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrat... | 11/18/2003 |
