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| Number | Title | Issue Date |
| 8188302 | Hydroamination of alkenes A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group including a sp3 | 05/29/2012 |
| 7714149 | Chiral spiro compounds and their use in asymmetric catalytic reactions The present invention provides a chiral ligand, represented by a formula or its enantiomer: X and X′ can be independently O, NH, NR, NCOR or S; each of Z1-Z7 and Z1′-Z7′ can... | 05/11/2010 |
| 7683186 | Optically active biaryl phosphorus compound and production process thereof A phosphorus compound of formula (1): wherein R1 denotes a hydrogen atom or a hydroxy protective group; R2 denotes a group defined by the following formula (R2-1) or (R2-2); R | 03/23/2010 |
| 7417156 | Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily in one additional step into four different dimers (4-7). Alcohol and ... | 08/26/2008 |
| 7374900 | Fluorescent substrates for detecting organophosphatase enzyme activity Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen;... | 05/20/2008 |
| 7358377 | Schweinfurthin analogues Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods c... | 04/15/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7300766 | Polymeric ammonium and or phosphonium salts having added π-electrons and higher molecular weight as enhancers for chemiluminescent systems A compound for enhancing the light output of a chemiluminescent system and, in particular, a stabilized, triggerable 1,2-dioxetane, is obtained by reacting a polyvinylbenzyl halide and a bilinker with either a trisubstituted amine or trisubstituted phosphine. A fluo... | 11/27/2007 |
| 7253298 | Process for preparing nitrile compounds from ethylenically unsaturated compounds The present invention concerns a process for hydrocyanating ethylenically unsaturated organic compounds to compounds containing at least one nitrile function. It relates more particularly to the hydrocyanation of diolefins such as butadiene or of substituted olefins... | 08/07/2007 |
| 7235675 | Conjugates of mycophenolic acid The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or olig... | 06/26/2007 |
| 7183405 | Compositions and methods for labeling oligonucleotides A novel method for the labeling of oligonucleotides which results in the economical synthesis of 5′ labeled molecules. A set of suitably protected and carefully selected set of amino linkers, a modified deprotination/cleavage protocol and standard coupling methodo... | 02/27/2007 |
| 7150967 | Fluorescent tags for amino acid and nucleic acid analysis Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are highly reactive with thiol containing species are provided. Fluoresce... | 12/19/2006 |
| 7112684 | Compounds and methods for fluorescent labeling Dye reagents useful in labeling biological materials are provided along with methods for their use. ... | 09/26/2006 |
| 7087416 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 08/08/2006 |
| 7033993 | Polypeptide having larvae growth inhibiting or insecticidal effect on scarabaeidae insects Through screening using an antibody to a polypeptide that constitutes a parasporal body in sporangia of Bacillus popilliae and has a larvae growth inhibiting or insecticidal effect on a Scarabaeidae insect and through polymerase chain reaction, polynucleotide... | 04/25/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6921756 | Inhibitors of β-lactamase The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 07/26/2005 |
| 6921774 | Compounds and their use as glycine transport inhibitors The invention provides novel compounds of the formula I below: wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine transporter and useful in the ... | 07/26/2005 |
| 6916942 | Process for the preparation of C-4 carbonate taxanes A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents ... | 07/12/2005 |
| 6878665 | Diphosphines, their complexes with transisition metals and their use in asymmetric synthesis The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): in which: R1 and R2 are a (C5-C7)cycloalkyl... | 04/12/2005 |
| 6872838 | Water soluble prodrugs of hindered alcohols The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals. ... | 03/29/2005 |
| 6831098 | Hesperetin pro-forms with enhanced bioavailablility A hesperitin pro-form is provided. The invention provides both a hydrophilic and lipophilic hesperetin pro-form. A pharmaceutical composition is provided which is suitable for topical or oral administration in an individual, the composition comprising a hydrophilic ... | 12/14/2004 |
| 6774142 | Inhibition by 3-deoxyflavonoids of T-lymphocyte activation and therapies related thereto 3-Deoxyflavonoid compounds and methods for inhibiting T-cell activity and treating diseases and disorders (e.g., autoimmune disorders, inflammatory disorders, diabetes, ALS, MS, rheumatoid arthritis, etc.). In some cases the efficacy and/or duration of action of lut... | 08/10/2004 |
| 6767716 | Chemluminescent systems containing unsaturated 1,2-dioxetanes A chemiluminescent 1,2-dioxetane includes an alkaline phosphatase triggerable stable 1,2-dioxetane; a polymeric enhancer which is either an ammonium or phosphonium salt of a polyvinylbenzyl chloride and an aqueous enzyme diluent or stabilizer which corresponds to bl... | 07/27/2004 |
| 6664380 | Perfluorosulfonylmethide compounds; use thereof for carbon-carbon bond formation Free perfluorosulfonylmethide compounds and metal salts thereof show strong catalytic activity in carbon-carbon bond formation reactions, in amounts as low as 0.1 mole %. Fluorous media may be used, especially biphasic fluorous media enabling ready recycl... | 12/16/2003 |
| 6656927 | Ip3 receptor ligands A compound represented by the general formula (I) or a salt thereof, wherein R represents a group represented by the following formula (A), (B) or (C) wherein R1 and R2 independently represent a C1-6 alkyl group, R3 | 12/02/2003 |
| 6645951 | Benzopyran or thiobenzopyran derivatives The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds according to Formula I: ##STR1## The present invention further pro... | 11/11/2003 |
| 6630114 | Calixarene derivatives, preparation method and use of said derivatives to extract antinides and lathanides The invention relates to new calixarenes according to the formula: ##STR1## wherein R1 and R2, which may be identical or different, are alkyl, alkoxy or aryl groups, and n is an integer equal to 2, 3 or 4. Said calixarenes may be used to ... | 10/07/2003 |
| 6613743 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and phy... | 09/02/2003 |
| 6541613 | Isoflavone derivatives Isoflavones are modified by esterification at one or more of the C4', C5, C6, and C7 positions to promote bioavailability, and especially to enhance solubility over the corresponding unesterified isoflavones. Preferred modifications produce a carboxylic a... | 04/01/2003 |
| 6515151 | Method for the preparation of novel sidechain-bearing taxanes and intermediates thereof Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing tax... | 02/04/2003 |
| 6472406 | Sulfonamidomethyl phosphonate inhibitors of beta-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel ଲ-lactamase inhibitors, which are structurally unrelated to the nat... | 10/29/2002 |
| 6472539 | Production process of diphosphine oxide and diphosphonate A process for producing a diphosphine oxide or diphosphonate represented by formula (1) as defined, which comprises treating, with a base, a phosphine compound represented by formula (2) as defined and adding the thus-treated phosphine compound to a nonpo... | 10/29/2002 |
| 6429202 | Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more phospholipids, and methods of treating or preventing atherosclerosis... | 08/06/2002 |
| 6417176 | Arylsulfonanilide phosphates The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,... | 07/09/2002 |
| 6410752 | Tocopherol derivatives and method for preparation thereof An object of the present invention is to provide the tocopherol derivatives represented by the following formula (I), and their salts: ##STR1## Wherein, R1, R2 and R3 are H or methyl group, and at least one positions selec... | 06/25/2002 |
| 6403811 | Recovery of chroman derivatives A process for recovering a concentrate of chromans from a distillate containing chromans is provided comprising the steps of: (1) forming chroman phosphates in the distillate; (2) subjecting the distillate to shearing forces, in the presence of a gas of f... | 06/11/2002 |
| 6380175 | Method for enhancement of delivery of THC by the administration of its prodrugs via the nasal route The present invention is directed to a method for enhancing the delivery of delta-9-tetrahydrocannabinol ("THC") to the brain of a mammal in need of treatment with this drug, by administering water-soluble prodrugs of THC intranasally.... | 04/30/2002 |
| 6346615 | Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an en... | 02/12/2002 |
