...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 8101782 | Compounds that inhibit cholinesterase Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The compounds of the invention are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the compound can... | 01/24/2012 |
| 8080674 | Preparation of polymer-free R-(+)-α-lipoic acid magnesium salt R-α-Lipoic acid and its homologs are converted to their magnesium salts in the presence of a reduced form of the acid, dihydro-(+)-lipoic acid in the case of R-α-lipoic acid itself. The reduced form serves as a polymerization inhibitor, resulting in a Mg di-R-α-l... | 12/20/2011 |
| 7919635 | Substituted phenylsulfur trifluoride and other like fluorinating agents Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermed... | 04/05/2011 |
| 7385067 | Process for the preparation of compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the... | 06/10/2008 |
| 7294487 | Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of monitoring gene expression, as well as for the analysis and quantitati... | 11/13/2007 |
| 7232915 | Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe... | 06/19/2007 |
| 7208169 | Biphenyl carboxamides The invention relates to novel biphenylcarboxamides of the formula (I) in which R1, R2, m, n, R3, Y and A are as defined in the disclosure, to a plurality... | 04/24/2007 |
| 7169942 | Cannabinoid derivatives, methods of making, and use thereof 1′-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having ac... | 01/30/2007 |
| 7129321 | Thiophosphine compounds and methods of making polymerizable compositions containing them and their use for making ophthalmic lenses Thiophosphine compounds (also named phosphine sulfide compounds) and their use for making polymerizable compositions which after polymerization give optically transparent articles, such as ophthalmic lenses, having improved mechanical and optical properties and in p... | 10/31/2006 |
| 7115651 | Macrocycles and uses thereof The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R0–R4, Z, X, A—B, D—E, G—J, and... | 10/03/2006 |
| 7115370 | Combinatorial oligonucleotide PCR The present invention is directed to a method of detecting gene expression and analysis of both known and unknown genes. In the method utilizing combinatorial oligonucleotide PCR™, no single molecular species of DNA gives rise to more than one fragment in a collec... | 10/03/2006 |
| 7091344 | Infrared chromophores An infrared dye, characterized in that the dye comprises of Formulae 1 to 5 ... | 08/15/2006 |
| 6900338 | Scavenger compounds The present invention provides novel compounds having scavenging and anti-ROS properties and pharmaceutical composition comprising these compounds for treatment of conditions associated with oxidative stress or free radical injury. The compounds of the invention are... | 05/31/2005 |
| 6787062 | Producing liquid crystals with CF2O bond The invention relates to a process for the preparation of compounds having at least one —CF2O— bridge in the molecule, which comprises initially reacting a bis(alkylthio)carbenium salt with a compound containing at least one hydroxyl group in the pres... | 09/07/2004 |
| 6664287 | Antioxidants This invention comprises administering to a human or animal in need of treatment an effective amount of an antioxidant lipoic acid derivative and/or pharmaceutically acceptable salts and solvates thereof for the treatment or prevention of pathological (in... | 12/16/2003 |
| 6576596 | Substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R1, R2 are each hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, --OR5, --OCOR6, ... | 06/10/2003 |
| 6570025 | Sulfur compound and use thereof This invention provides sulfur-containing (meth)acrylic ester compounds each of which is represented by the following formula (1); ##STR1## wherein R1 and R2 each independently represent a hydrogen atom or an alkyl group or may be fu... | 05/27/2003 |
| 6528627 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent oth... | 03/04/2003 |
| 6512003 | Synthetic spiroketal pyranes as potent anti-cancer agents and use Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The c... | 01/28/2003 |
| 6472488 | (Thio) (meth) acrylate monomers, intermediate compounds for the synthesis of these monomers, polymerizable compositions and polymers obtained, and their optical and ophthalmic uses Polymerizable compositions from novel monomers that correspond to the formula: ##STR1## in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at lea... | 10/29/2002 |
| 6458908 | Sulfur-containing unsaturated carboxylate compound and its cured products A sulfur-containing unsaturated carboxylate compound comprising a sulfur-containing substituent and at least two ,ଲ-unsaturated carboxylic acid residues, which are each attached to a secondary or tertiary carbon atom via an oxygen atom; a pol... | 10/01/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6342517 | Potassium channel activators and their use Novel thienopyran compounds are disclosed, useful as anti-hypertensive agents and for asthma treatment. One group of the compounds has a heterocyclic ring spiro-connected at the 7-position of the thienopyran ring structure. Use of thienopyran compounds in... | 01/29/2002 |
| 6313316 | Polyisocyanate compounds, process for producing the same, and optical materials using the same The invention provides a novel polyisocyanate compound which is useful as a starting material for an optical material having a high refractive index, a low dispersion and excellent optical characteristics, and a process for producing this compound at good... | 11/06/2001 |
| 6307062 | (Thio) (meth) acrylate monomers, intermediate compounds for the synthesis of these monomers, polymerisable compositions and polymers obtained, and their optical and ophthalmic uses The novel monomers correspond to the formula: ##STR1## in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.... | 10/23/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6245506 | Integrated sequencing device The invention is based on the discovery that the sequence of monomers in a polymeric biomolecule can be determined in a self-contained, high pressure reaction and detection apparatus, without the need for fluid flow into or out from the apparatus. The pre... | 06/12/2001 |
| 6043361 | Polymerisable monomers and polymers The invention relates to compounds of the formulae: processes for their preparation, polymers, co-polymers or block co-polymers containing them or their use as monomers or co-monomers in free radical polymerisation and in the manufacture of adhesives, den... | 03/28/2000 |
| 6022938 | Compounds with isocyanate groups and masked groups reactive in relation to isocyanates Isocyanato compounds with capped, isocyanate-reactive groups are those of the formula I ##STR1## where R1 and R2 are hydrogen, C1 -C10 -alkyl, C6 -C10 -aryl or C7 -C10 | 02/08/2000 |
| 6022895 | Substituted amino compounds and their use as substances having an analgesic effect Substituted amino compounds of general formula (I) ##STR1## are described, as are a method of preparing them and their use as drugs, especially as analgesics.... | 02/08/2000 |
| 6020371 | Antipicornaviral compounds compositions containing them and methods for their use Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treatin... | 02/01/2000 |
| 5914351 | Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a... | 06/22/1999 |
| 5872121 | Pesticidal hydrazide derivatives A compound of the formula ##STR1## wherein R is a) phenyl; phenyl(C1 -C4 alkoxy); phenoxy; or benzyl; the phenyl ring of each substituent being optionally substituted with one or more of halogen, nitro, C1 -C8 | 02/16/1999 |
| 5837725 | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R1, R2, R3, R4, R5 and n are as defined herein. The novel compounds are useful for modulating gene expression of ... | 11/17/1998 |
| 5830825 | 3-aryl-tetronic acid derivatives, the production thereof and the use thereof as antiparasitic agents The present invention relates to new 3-aryl-4-hydroxy-Ɗ3 -dihydrofuranone derivatives of the formula (I) ##STR1## in which A and B together with the carbon atom to which they are bonded form an unsubstituted or substituted 5- to 7-membere... | 11/03/1998 |
| 5824484 | RXR homodimer formation The invention provides a method of screening a substance for the ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the presence of homodimer... | 10/20/1998 |
| 5767288 | Photolabile linkers and probes The invention relates to dithiane adducts of substituted benzoins and substituted benzoins derived therefrom each of which are useful as protecting groups, photolabile linkers, and fluorescent probes.... | 06/16/1998 |
| 5756766 | Composition for optical materials and use thereof A composition for optical materials is herein disclosed which comprises the following two components (a) and (b): (a) a component containing at least one of poly isocyanates represented by the formula (1) ##STR1## wherein A is an alkanediyl group or ... | 05/26/1998 |
| 5744569 | One-component and two-component polyurethane coating compositions In one-component and two-component polyurethane coating compositions comprising at least one reactive component capable of reacting with polyisocyanates, the reactive component is a compound A) containing an isocyanate group, a urethane, thiourethane or u... | 04/28/1998 |
| 5718845 | Tricyanovinyl substitution process for NLO polymers Nonlinear optical compounds which contain a heteroaromatic ring and may further comprise a tricyanovinyl group attached to the heteroaromatic ring.... | 02/17/1998 |