Class 549/218 - Phosphorus attached indirectly to the hetero ring by nonionic bonding

Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which phosphorus is attached indirectly to
No. of patents: 209
Last issue date: 09/02/2008

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Number	Title	Issue Date
7420000	Amino phosphonate and amino bis-phosphonate derivatives Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The compounds and compositions are useful in methods for treatment of various...	09/02/2008
7097995	Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-PFormula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached an...	08/29/2006
7087626	Pyrrole derivatives as pharmaceutical agents Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ...	08/08/2006
7019056	Flame retardants which contain phosphorus, and flame-retardant thermoplastic molding compositions An oligophosphate of general formula is disclosed. The oligophosphate is suitable as a flame retardant for thermoplastic molding compositions that exhibit a good flame-retardant effect, improved dimensional stability un...	03/28/2006
7019024	Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ...	03/28/2006
6916831	Flavone acetic acid analogs and methods of use thereof Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n...	07/12/2005
6906007	Phenyl-substituted 5,6-dihydropyrone derivatives for use as pesticides and herbicides The present invention relates to novel phenyl-substituted 5,6-dihydro-pyrone derivatives of the formula (I) in which W, X, Y, Z, G, A, B, Q1 and Q2 are each as defined in the description...	06/14/2005
6864283	Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity Compounds of formula (I) wherein R1is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubs...	03/08/2005
6737416	Phosphonic acid derivative having inhibitory activity against carboxypeptidase B A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2...	05/18/2004
6677461	Ligands and asymmetric catalysts made by using the same A ligand expressed by a general formula (1) in claim 1, wherein R1, R2 and R3 denote substituting groups on aromatic rings, X is P or As, and n is 1 to 3....	01/13/2004
6590107	Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pha...	07/08/2003
6566508	Fluorogenic compounds and uses therefor Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compounds include sugar...	05/20/2003
6528627	Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent oth...	03/04/2003
6515183	Chiral diphenyldiphosphines and d-8 metal complexes thereof Compounds of formula III, ##STR1## wherein R6 und R7 signify identical or different secondary phosphino; R8 is --CH2 --OH, --CH2 --NH2, --CH2 --O--B--FU, --CH2 --NH	02/04/2003
6514953	Calcium (3S) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1 -benzyl-2-(phosphonooxy)propylcarbamate The invention relates to calcium (3S) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1 -benzyl-2-(phosphonooxy)propylcarbamate, to processes for its preparation, and to its use in the treatment of diseases caused by retroviruses. ...	02/04/2003
6500811	Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved....	12/31/2002
6479471	NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated ଱-Linked Acidic Dipeptidase (NAALADase) enzym...	11/12/2002
6472414	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters...	10/29/2002
6410751	Water soluble tri-substituted 1, 2-dioxetane compounds having increased storage stability, synthetic processes and intermediates Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more w...	06/25/2002
6372895	Fluorogenic compounds Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compounds include sugar...	04/16/2002
6365592	Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1B (PTP-1B) The invention encompasses compounds represented by formula I: ##STR1## as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme....	04/02/2002
6362348	Additive for inkjet printing, recording solution, method for preventing discoloration and fading of image, and recording sheet An additive for inkjet printing, comprising a stabilized ascorbic acid derivative. Also disclosed are a recording solution, a method for preventing discoloration and fading of an image, and a recording sheet, each using the additive. The color change of a...	03/26/2002
6346615	Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an en...	02/12/2002
6333291	Optically active diphosphine compound, production intermediate thereof, transition metal complex containing the compound as ligand and asymmetric hydrogenation catalyst containing the complex This invention provides a novel diphosphine compound which is useful as a ligand of catalysts for asymmetric synthesis reactions, particularly asymmetric hydrogenation reaction. Particularly, it provides a diphosphine compound represented by a general for...	12/25/2001
6331532	Mitochondrially targeted antioxidants The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cati...	12/18/2001
6313159	Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors The present invention relates to metabotropic glutamate receptor ligand derivatives and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit angiogenesis, and to treat glutamate abnormalities, compulsiv...	11/06/2001
6288280	Racemization of atropisomeric bis(phosphine oxide) compounds A process for the racemization of atropisomeric bis(phosphine oxide) compounds of formula I: ##STR1## in their (S) or (R) or non-racemic form, is useful for preparing optical active bisphosphine ligands, that form optical active complexes with transi...	09/11/2001
6281390	Chiral diphenyldiphosphines and d-8 metal complexes thereof Compounds of formula III, ##STR1## wherein R6 und R7 signify identical or different secondary phosphino; R8 is --CH2 --OH, --CH2 --NH2 --, --CH2 O----B--FU, --CH2 --NH...	08/28/2001
6277833	Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments....	08/21/2001
6271397	L-ascorbic acid-2-phosphoric acid potassium crystal and method for producing the same A high-purity L-ascorbic acid-2-phosphoric acid potassium crystal having excellent stability, and a method for simply producing the high-purity L-ascorbic acid-2-phosphoric acid potassium in a high yield by adding dropwise a solution containing L-ascorbic...	08/07/2001
6248848	Optically active phosphine derivative having at least two vinyl groups, polymer produced using the same as monomer, and transition metal complexes of these A 2'-diarylphosphino-1,1'-biphenylen-2-yloxy(6,6'-divinyl-1,1'-binaphthalene -2,2'-diyloxy)phosphine derivative is disclosed, which is represented by general formula (I): ##STR1## wherein Ar is an optionally substituted phenyl or naphthyl; R1	06/19/2001
6184390	Catalyst for bisalkoxycarbonylation of olefins, and method for production of succinate derivatives A catalyst for the bisalkoxycarbonylation of olefins comprising a noble metal compound and a phosphine chalcogenide of the following formula (1): ##STR1## wherein each of R1, R2 and R3 is, independently, an alkyl group or ...	02/06/2001
6150539	Triptolide prodrugs having high aqueous solubility Compounds useful in immunosuppressive and anti-inflammatory treatment are described. The compounds are hydrolyzable triptolide analogs with improved water solubility and generally lower toxicity than the parent compound....	11/21/2000
6133459	Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a c...	10/17/2000
6087513	Epoxidation process for aryl allyl ethers A process for making an aromatic glycidyl ether epoxy compound by contacting an allyl ether made from the hydroxy moiety of a hydroxy-containing aromatic compound with an inorganic or organic hydroperoxide oxidant in the presence of a transition metal com...	07/11/2000
6075152	Process for preparing isochroman-3-ones The present invention relates to a process for preparing an isochroman-3-one of the formula (I) by reacting a 1,2-bishalomethylbenzene of the formula (II) ##STR1## in which X is chlorine, bromine or iodine with carbon monoxide and water at a CO ...	06/13/2000
6063937	Method of making ascorbyl monophosphates The present invention provides a method of making alkali metal and alkaline earth metal salts of L-ascorbic acid 2-monophosphate comprising reacting a L-ascorbic acid 2-polyphosphate under alkaline conditions with an alkali metal or alkaline earth metal s...	05/16/2000
6054444	Phosphonic acid derivatives The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated ଱-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit...	04/25/2000
6036892	Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more w...	03/14/2000
6030996	Mur D inhibiting compounds, compositions containing such compounds and methods of use The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: ##STR1## wherein: X represents OH, OC1-6 alkyl, O-aryl, O-Har, uridinyl, 5-iodouridinyl or O--Y+, wherein Y	02/29/2000

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Class 549/218 - Phosphorus attached indirectly to the hetero ring by nonionic bonding