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| Number | Title | Issue Date |
| 7432263 | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compostions are useful in the treatment of diseases ... | 10/07/2008 |
| 7193092 | Chiral diphosphorus compounds and their transition metal complexes The present invention relates to chiral diphosphorus compounds and their transition metal complexes, to a process for preparing chiral diphosphorus compounds and their transition metal complexes and also to their use in asymmetric syntheses. ... | 03/20/2007 |
| 7153809 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions Chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic al... | 12/26/2006 |
| 7105696 | Method for making nitrile compounds from ethylenically unsaturated compounds The invention concerns a method for hydrocyanation of ethylenically unsaturated organic compounds comprising at least a nitrile function. The invention provides a method for hydrocyanation of an ethylenically unsaturated hydrocarbon compound by reacting in liquid me... | 09/12/2006 |
| 7094907 | Ligands for asymmetric reactions The invention relates to a process for the manufacture of bidentate ligands of the formula IA and IIA, characterized in that N,N-(optionally substituted)dialkylamino phosphines bound to an aromatic carbon are lithiated in ortho-position and the lithiated compounds a... | 08/22/2006 |
| 7081533 | Cycloaliphatic/aromatic diphosphines and use thereof in catalysis The present invention concerns novel unsymmetrical chiral diphosphines of a mixed aliphatic-aromatic type and processes for synthesizing them, complexes of these compounds and their use as catalysts. ... | 07/25/2006 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6864283 | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity Compounds of formula (I) wherein R1is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubs... | 03/08/2005 |
| 6794328 | Diphosphine compound, production intermediate thereof, transition metal complex containing the compound as ligand and asymmetric hydrogenation catalyst containing the complex The present invention provides a novel phosphine compound, specifically to provide a novel phosphine compound useful as a ligand for the above catalysts, in particular, a novel catalyst having an excellent performance (chemical selectivity, enantio-selectivity, cata... | 09/21/2004 |
| 6590107 | Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pha... | 07/08/2003 |
| 6576771 | Oxymethoxy-3-aryl-pyrone derivatives The invention relates to novel oxymethoxy-3-aryl-pyrone derivatives of the formula (I) ##STR1## in which A, D, R1, R2, X, Y, Z and n have the meanings specified in the description, a process for their preparation and their use as pes... | 06/10/2003 |
| 6566298 | Diphosphines The invention relates to the preparation and use as catalysts of diphosphines of the formula (I) ##STR1## in which R is C6 -C14 -aryl or C4 -C13 -heteroaryl containing 1 to 3 heteroatoms selected from the group ... | 05/20/2003 |
| 6479471 | NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzym... | 11/12/2002 |
| 6462200 | Diphosphines The invention relates to the preparation and use as catalysts of diphosphines of the formula (I) ##STR1## in which R is C6-C.sub.14 -aryl or C4-C.sub.13 -heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of ... | 10/08/2002 |
| 6417375 | Furylphosphines and organometallic complexes containing them The present invention relates to novel water-soluble furylphosphines. It also relates to organometallic complexes comprising these furylphosphines and to the use of such complexes. It also relates to the process for the preparation of the water-soluble furylph... | 07/09/2002 |
| 6376532 | Bicyclic metabotropic glutamate receptor ligands The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.... | 04/23/2002 |
| 6355810 | Multibinding inhibitors of HMG-CoA reductase Disclosed are multibinding compounds which inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-COA reductase), the rate limiting enzyme in cholesterol biosynthesis. The multibinding compounds of this invention containing from 2 to 10 ligands cova... | 03/12/2002 |
| 6339161 | Group 8, 9 or 10 transition metal catalyst for olefin polymerization Olefin co- or homopolymers having a good molecular weight and short chain branching may be prepared in the presence of a tridentate complex of a Group 8, 9 or 10 metal.... | 01/15/2002 |
| 6162929 | Process for the manufacture of bisphosphine oxide and bisphosphonate compounds A process for the manufacture of bisphosphine oxide compounds and bisphosphonates as intermediates for the production of bisphosphine ligands, in which in a single step process a) a phosphine oxide compound is reacted in an organic solvent at -70° C. to ... | 12/19/2000 |
| 6153758 | Heteroarylic-arylic diphosphines as chiral ligands Diphosphines of a mixed heteroarylic-arylic type, wherein the phosphine group carrying backbone is constituted by the interconnection of a five-atom heteroaromatic ring and a carbocyclic aromatic ring, forming an atropoisomeric chiral system with a C... | 11/28/2000 |
| 6133191 | Heteroaromatic diphosphines as chiral ligands Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in stereocontrolled reactions, such a... | 10/17/2000 |
| 6107254 | 5-(Dioxabicyclohept-6-yl)-cyclohexenone oxime ethers, and the preparation and thereof use 5-(Dioxabicyclohept-6-yl)cyclohexenone oxime ethers of the formula I ##STR1## where: R1 is hydrogen, the equivalent of an agriculturally useful cation, C1 -C10 -alkylcarbonyl, C1 -C10 -alkylsulfo... | 08/22/2000 |
| 6043270 | Protein kinase C modulators V Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the polyacetate-, diaminobenzyl alcohol-, diacylglycerol- and bryostatin-classes.... | 03/28/2000 |
| 6030996 | Mur D inhibiting compounds, compositions containing such compounds and methods of use The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: ##STR1## wherein: X represents OH, OC1-6 alkyl, O-aryl, O-Har, uridinyl, 5-iodouridinyl or O--Y+, wherein Y | 02/29/2000 |
| 6028216 | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives The present invention relates to asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives.... | 02/22/2000 |
| 6025344 | Certain dioic acid derivatives useful as NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzym... | 02/15/2000 |
| 6001823 | Treatment or prophylaxis of diseases caused by pilus-forming bacteria Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infect... | 12/14/1999 |
| 5985855 | Treatment of global and focal ischemia using NAALADase inhibitors The present invention includes compositions and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include glutamate-derived hydroxyphosphinyl derivative compou... | 11/16/1999 |
| 5968915 | Naaladase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme w... | 10/19/1999 |
| 5830915 | Phosphinic acid amides as matrix metalloprotease inhibitors The invention provides compounds which are useful as inhibitors of matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having... | 11/03/1998 |
| 5824662 | Treatment of global and focal ischemia using naaladase inhibitors The present invention includes compositions and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include glutamate-derived hydroxyphosphinyl derivative compou... | 10/20/1998 |
| 5789394 | Anti-viral compounds Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH2, CH-halogen, CH--N3, or C.dbd.CH2 ; Q and U are independently se... | 08/04/1998 |
| 5750729 | Compounds and methods for making and using same In accordance with this invention novel compounds are provided that are selected from saturated and unsaturated pyrans and furans substituted with at least a phosphonate group and a heterocyclic base. These compounds are useful as antiinfectives, flame re... | 05/12/1998 |
| 5739396 | Asymmetric ligands useful for transition metal catalyzed bond forming reactions Ligands useful for transition metal catalyzed bond forming reactions are provided with a metal binding portion having at least one metal binding moiety ##STR1## wherein Ar and Ar' each is an aryl or a heteroaryl. These ligands may be prepared by... | 04/14/1998 |
| 5719291 | Cyclohexane derivatives Compounds of the formula ##STR1## which have antifungal activity.... | 02/17/1998 |
| 5672592 | Certain phosphonomethyl-pentanedioic acid derivatives thereof The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme w... | 09/30/1997 |
| 5508438 | Phosphorus compounds Novel, racemic and optically active phosphorus compounds of the formula ##STR1## wherein R signifies lower alkyl, lower alkoxy, hydroxy or a protected hydroxy group, R1 and R2 are different from each other and represent lower al... | 04/16/1996 |
| 5468870 | Dyes and dye-donor elements for use in thermal dye sublimation transfer Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR1 or CONR2 R | 11/21/1995 |
| 5436245 | Phosphate substituted amino or imino acids useful as antihypertensives Hypotensive activity is exhibited by new phosphonate substituted amino or imino acids of the formula ##STR1## isomeric mixtures thereof and pharmaceutically acceptable salts thereof, wherein: X is an imino or amino acid of the formula ##STR2##... | 07/25/1995 |
| 5393729 | 3-aryl-pyrone derivatives The invention relates to 3-aryl-pyrone derivatives of the general formula (I) ##STR1## in which the substituents are as defined in the specification. The compounds are useful as pesticides, herbicides and fungicides.... | 02/28/1995 |
