In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
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| Number | Title | Issue Date |
| 7601848 | Multifunctional reagent for the synthesis of thiol modified oligomers The invention relates to compounds of formula (I), wherein Z represents a hydrocarbon with 2 to 28 C atoms, wherein Z can also comprise elements N, O, P, S, Si and halogen as heteroatoms, R1 and R2 are identical or different sulfur protecting g... | 10/13/2009 |
| 7385067 | Process for the preparation of compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the... | 06/10/2008 |
| 7371777 | Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ... | 05/13/2008 |
| 7348441 | Methyl 2,4,9-trithiaadamantane-7-carboxylate Methyl 2,4,9-trithiaadamantane-7-carboxylate and a method for its manufacture is disclosed. The method reacts oxidized methyl triallyl acetate with a Lewis acid and a sulphuring agent. ... | 03/25/2008 |
| 7301705 | Alicyclic compound for optical material The alicyclic compound of the present invention has a five- or more membered ring structure having an epithioethylene linkage and/or an epidithioethylene linkage, and has tow or more sulfur atoms in its molecule. Optical materials produced by curing the alicyclic co... | 11/27/2007 |
| 7091344 | Infrared chromophores An infrared dye, characterized in that the dye comprises of Formulae 1 to 5 ... | 08/15/2006 |
| 6995276 | Cyclic disulfide compound, process of producing the same and optical product comprising the same A compound capable of giving optical materials that may be high in both refractive index and Abbe's number and may be excellent in heat resistance and transparency, and a process that may produce the same with good efficiency are disclosed. The compound may be a cyc... | 02/07/2006 |
| 6900338 | Scavenger compounds The present invention provides novel compounds having scavenging and anti-ROS properties and pharmaceutical composition comprising these compounds for treatment of conditions associated with oxidative stress or free radical injury. The compounds of the invention are... | 05/31/2005 |
| 6875894 | Bis(alkylthio)carbenium salts The invention relates to bis(alkylthio)carbenium salts of the formula I with the stated definitions for R1, R2, R3 and Y−, and to a process for the preparation th... | 04/05/2005 |
| 6787062 | Producing liquid crystals with CF2O bond The invention relates to a process for the preparation of compounds having at least one —CF2O— bridge in the molecule, which comprises initially reacting a bis(alkylthio)carbenium salt with a compound containing at least one hydroxyl group in the pres... | 09/07/2004 |
| 6664287 | Antioxidants This invention comprises administering to a human or animal in need of treatment an effective amount of an antioxidant lipoic acid derivative and/or pharmaceutically acceptable salts and solvates thereof for the treatment or prevention of pathological (in... | 12/16/2003 |
| 6566521 | Valeraldehyde and process for its preparation Bidentate phosphine ligands of the formula ##STR1## wherein the substituents are as defined in the specification and a process for preparing linear aldehydes by hydroformylating internal olefins using such phosphine ligands.... | 05/20/2003 |
| 6562861 | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors ##STR1## Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydroxyalkyl, ... | 05/13/2003 |
| 6534545 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: ##STR1## X represents: (i) either a radical of formula: (a) ##STR2## and Y represents a radical of formula: (b) ##STR3## (ii) or a radical of formula: (c... | 03/18/2003 |
| 6458908 | Sulfur-containing unsaturated carboxylate compound and its cured products A sulfur-containing unsaturated carboxylate compound comprising a sulfur-containing substituent and at least two ,ଲ-unsaturated carboxylic acid residues, which are each attached to a secondary or tertiary carbon atom via an oxygen atom; a pol... | 10/01/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6344556 | Polymerisable monomers and polymers The invention relates to compounds of the formulae: ##STR1## processes for their preparation, polymers, co-polymers or block co-polymers containing them or their use as monomers or co-monomers in free radical polymerisation and in the manufacture of adhes... | 02/05/2002 |
| 6071861 | Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production The dihalopropene compounds of the general formula [I ] have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.... | 06/06/2000 |
| 6043361 | Polymerisable monomers and polymers The invention relates to compounds of the formulae: processes for their preparation, polymers, co-polymers or block co-polymers containing them or their use as monomers or co-monomers in free radical polymerisation and in the manufacture of adhesives, den... | 03/28/2000 |
| 6022895 | Substituted amino compounds and their use as substances having an analgesic effect Substituted amino compounds of general formula (I) ##STR1## are described, as are a method of preparing them and their use as drugs, especially as analgesics.... | 02/08/2000 |
| 5718845 | Tricyanovinyl substitution process for NLO polymers Nonlinear optical compounds which contain a heteroaromatic ring and may further comprise a tricyanovinyl group attached to the heteroaromatic ring.... | 02/17/1998 |
| 5698580 | Antiviral agent containing benzodithiin derivative as active ingredient Antiviral agents comprising, as an active ingredient, a 1,4-dihydro-2,3-benzodithiin derivative of the formula ##STR1## wherein each symbol is as defined in the Specification, or a pharmacologically acceptable salt thereof. The antiviral agents of th... | 12/16/1997 |
| 5668168 | 1,2-dithiin antiinfective agents This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida... | 09/16/1997 |
| 5650098 | Substituted naphthopyrans Described are novel reversible photochromic 2H-naphtho[1,2-b]pyran compounds, examples of which are compounds having certain substituents at the 5 and 6-positions of the naphtho portion of the naphthopyran and at the 2-position of the pyran ring, e.g., 2,... | 07/22/1997 |
| 5621108 | Processes and intermediates for preparing macrocycles Novel processes for the preparation of lactam- and lactone-containing macrocyles are provided. In preferred embodiments, rapamycin and demethoxyrapamycin are prepared by a convergent synthesis regime. Intermediates useful in the synthetic processes are al... | 04/15/1997 |
| 5583235 | Preparation of symmetrical and unsymmetrical 3,6-disubstituted-1,2-dithiins having antifungal activity The present invention provides an improved procedure for the preparation of 3,6-disubstituted-1,2-dithiin derivatives, especially unsymmetrical 1,2-dithiins. In addition, the process offers significant process, scaleup, and safety advantages over the prev... | 12/10/1996 |
| 5580897 | 1,2-dithiins having antifungal activity Novel 1,2-dithiin compounds useful as antifungal or anti-infective agents, as well as methods for their use as such, are described. The 1,2-dithiin compounds are particularly effective in treating infections, especially those caused by Candida albicans, C... | 12/03/1996 |
| 5556875 | 1,2-dithiin antiinfective agents This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida... | 09/17/1996 |
| 5502073 | Heterocyclic pesticidal compounds Compounds of the formula (I) ##STR1## which contain between 10 and 27 carbon atoms, and wherein m and n are independently selected from 0, 1 and 2; R2a is hydrogen, methyl, or ethyl; R2b is acetylene or contains between 3 and 18... | 03/26/1996 |
| 5436361 | Process for synthesizing enediynes A process for synthesizing enediynes is provided. Specifically, the formed enediynes contain a hex-3-ene-1,5-diynyl group. Production of the enediynes involves adding a base to a propargylic halide in the presence of a chelating agent, which causes a carb... | 07/25/1995 |
| 5405968 | Polyketomethine dyes Methine dyes with a polyketo group I ##STR1## where A is ##STR2## R1 is a 5- or 6-membered cycloaliphatic radical which contains one or two hetero atoms from the group --NR4 --, --O-- and --S-- and which may be fused t... | 04/11/1995 |
| 5296505 | Compositions of retinoids substituted with a dithiane ring, their use, and process for preparing the compounds The invention relates to a stereospecific derivative of formula: ##STR1## in which R is hydrogen or a C1 -C4 thioalkyl. The invention also relates to the use of these compounds for the manufacture of stereospecific retinal or re... | 03/22/1994 |
| 5283355 | Benzoquinone compounds Compounds of the Formula (5) and processes for their preparation and use, particularly in the manufacture of unsymmetrical triphenodioxazine dyes: ##STR1## wherein: Y is H, alkyl, substituted alkyl, alkoxy, Cl or Br; R is a group of Formula (3) ##STR... | 02/01/1994 |
| 5202348 | Thiarubrine antifungal agents This invention pertains to a novel group of Thiarubrine substances and closely related derivatives, useful as antifungal and antibiotic agents.... | 04/13/1993 |
| 5086187 | Herbicidal pyrones Compounds of the general formula, including isomers and tautomers thereof: ##STR1## wherein: R1 to R5 are as defined in the text; the compounds have herbicidal and plant growth regulating properties; including compositions conta... | 02/04/1992 |
| 4985411 | Dialkyl-substituted dithianes and pesticidal compositions The present invention provides compounds of the formula (I): ##STR1## wherein m and n are independently selected from 0, 1 or 2, ##STR2## R is selected from hydrogen, methyl or ethyl; R1 is selected from C1-4 hydrocarbyl su... | 01/15/1991 |
| 4975457 | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis Certain trans-2,3-disubstituted-2,3-dihydro-5-hydroxybenzofurans are described. The synthesis involves an intramolecular Michael addition to yield the thermodynamic trans isomer. The compounds were found to be inhibitors of 5-lipoxygenase, an enzyme cruci... | 12/04/1990 |
| 4946861 | 1,3-dithian-2-ylidenes, their oxides, pharmaceutical compositions, and methods of use thereof The invention relates to the use of ketenethioacetals of the formula ##STR1## in which R1 represents aryl or heteroaryl, R2 represents hydrogen, an optionally substituted hydrocarbon radical, heteroaryl, an acyl radical, a group... | 08/07/1990 |
| 4927845 | Compounds of the anthraquinone series Anthralin analogues containing a thio-substituent, especially in one or more of the positions 2-, 7- and 10- of the anthralin ring. They may be made by reacting an anthralin derivative (e.g. 10-bromoanthralin) with a thiol or a compound containing a group... | 05/22/1990 |
| 4898986 | Inosose derivatives, production and use thereof Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X1 and X2 are both halogen; X1 is hydrogen and X2 is halogen; or X1 is --SQ1 and X2 is ... | 02/06/1990 |