"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
|6156744||DT-diaphorase directed anti-tumor agents|
The present invention relates to a novel benzoquinone, 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone and its esters. The compounds can be used to treat tumors exhibiting elevated levels of the enzyme DT-diaphorase....
|4806531||2,3-bis(aziridinyl)-1,4-naphthoquinone sulfonate derivatives having antineoplastic activity|
The compounds of the formula: ##STR1## wherein R is selected from the group consisting of: (a) a substituent having the formula: ##STR2## wherein R1, R2 and R3 are each independently selected from the group...
A 2-cyanoaziridinyl-(1)-2-substituted-aziridinyl-(1)-methane ##STR1## wherein R is a nitrile or carbamoyl group, and R1 and R2 each independently is a hydrogen atom, an aliphatic hydrocarbon radical containing up to 10 carbon atoms o...
|4337196||Method for producing 3,6-bis(carboethoxyamino)-2,5-diaziridinyl-1,4-benzoquinone|
A method is described of preparing a diaziridinyl diaminobenzoquinone-N, N'-dicarboxylate compound selected from dialkyl, di(arylalkyl), or diphenyl diaminobenzoquinone-N, N'-dicarboxylates, said method comprising: reacting a diaminohydroquinone of the formula...
|4233215||Aziridinyl quinone antitumor agents|
The use of aziridinyl quinones as antitumor agents against transplanted tumors in mice is disclosed. A compound which has been found to be particularly effective is the compound 2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone. Treatment is de...
|4152401||Chelated lithium aluminum compounds|
Chelated lithium aluminum compounds are prepared by mixing a lithium aluminum compound such as a lithium aluminum hydride with a chelating agent wherein the agent contains at least one nitrogen atom. The chelating agent is a tertiary polyamine or aminoeth...