Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 8178698 | Methods of synthesizing cyclic nitro compounds The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal ce... | 05/15/2012 |
| 7829729 | 1-glycidyl-3,3-dinitroazetidine containing explosive moiety and preparation method thereof Disclosed is a 1-glycidyl-3,3-dinitroazetidine(GDNAZ) of Formula I wherein dinitroazetidine group which is a high energy group having unit structure of explosive moiety is incorporated to a monomer, and the method thereof. By using the GDNAZ of the present invention... | 11/09/2010 |
| 7745643 | Methods of synthesizing cyclic nitro compounds The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal ce... | 06/29/2010 |
| 7511159 | Azetidine ring compounds and drugs comprising the same It is intended to provide compounds having EDG-5 antagonism. Because of having EDG-5 antagonism, compounds of the formula (I): wherein each symbol is as defined in the description; salts thereof, N-oxides thereof, solvates ... | 03/31/2009 |
| 7429668 | Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide. ... | 09/30/2008 |
| 7378440 | Substituted benzoylureido-o-benzoylamides, process for their preparation and their use The invention relates to substituted benzoylureido-o-benzoylamides and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of the formula I in which... | 05/27/2008 |
| 7378409 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis. | 05/27/2008 |
| 7365061 | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 04/29/2008 |
| 7354905 | Prodrugs of thrombin inhibitors There is provided compounds of formula I, R1O(O)C—CH2—(R)Cgl-Aze-Pab-R2I wherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-li... | 04/08/2008 |
| 7338947 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma, pro... | 03/04/2008 |
| 7309714 | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved... | 12/18/2007 |
| 7273858 | Salts There is provided pharmaceutically-acceptable acid addition salts of compounds of formula I, wherein R1 represents C1-2 alkyl substituted by one or more fluoro substituents; | 09/25/2007 |
| 7262308 | Process for producing optically active azetidine-2-carboxylic acids An optically active N-protected azetidine-2-carboxylic acid (5) can be produced by preparing an optically active 4-amino-2-halobutyric acid (3) by halogenating an optically active 3-hydroxy-2-pyrrolidinone (1) with inversion of con... | 08/28/2007 |
| 7247748 | Amide compounds and methods of using the same Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are ... | 07/24/2007 |
| 7241902 | Allylmercaptocaptopril compounds and uses thereof Compounds which are the reaction product of allicin and ACE-inhibiting compounds are useful in treating hypertension, elevated triglycerides, and elevated insulin. ... | 07/10/2007 |
| 7238683 | Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is in... | 07/03/2007 |
| 7232812 | Substituted azetidine compounds, their preparation and use as medicaments The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals. ... | 06/19/2007 |
| 7202236 | Modified release pharmaceutical formulation A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R1 represents C?1-2#191 alkyl substituted by one or more fluoro substituents; R2 represents hydrogen, hydroxy, methoxy or ethoxy;... | 04/10/2007 |
| 7183270 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and ... | 02/27/2007 |
| 7176210 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein ... | 02/13/2007 |
| 7163937 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and a... | 01/16/2007 |
| 7141570 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formula I described herein. ... | 11/28/2006 |
| 7132414 | Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R1 represents a radical —NHCOR4 or —N(R5)—Y—... | 11/07/2006 |
| 7129233 | Mandelic acid derivatives and their use as thrombin inhibitors There is provided a compound of formula I wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including pro... | 10/31/2006 |
| 7087604 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, r... | 08/08/2006 |
| 7087594 | Alkyl ether derivatives or salts thereof An alkyl ether represented by the general formula: or its salt. This compound has activity to protect neurons, activity to accelerate nerve regeneration and activity to accelerate neurite extension and hence is u... | 08/08/2006 |
| 7084120 | Prodrugs of DP IV-inhibitors Prodrug compounds of unstable inhibitors of the serine peptidase dipeptidyl peptidase IV, are used in the treatment of various disorders, especially of metabolic disorders. The Prodrug compounds can be used in the treatment of impaired glucose tolerance, glucosuria,... | 08/01/2006 |
| 7067509 | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: | 06/27/2006 |
| 7060697 | Immunosuppressant compounds and compositions The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by... | 06/13/2006 |
| 7056907 | Mandelic acid derivatives and their use as thrombin inhibitors There is provided a compound of formula (1) and pharmaceutically-acceptable derivatives (including prodrugs) thereof. Which compound and derivatives are useful as, or are as useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, a... | 06/06/2006 |
| 6995183 | Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; | 02/07/2006 |
| 6962633 | Amine azide propellant A novel family of amine azides having a cyclic structure therein is disclosed. These compounds have attractive properties as rocket propellants. ... | 11/08/2005 |
| 6921758 | Amino acid derivatives There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibit... | 07/26/2005 |
| 6921822 | Process for stereoselectively reducing 4-aryl-4-oxobutanoic acid derivatives The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts. ... | 07/26/2005 |
| 6888007 | Crystalline forms of EtO2C-Ch2-(R)Cgi-Aze-Pab-OH There is provided EtO2C—CH2—(R)Cgl-Aze-Pab-OH, or a pharmaceutically-acceptable salt thereof, in a form which is substantially crystalline. It has been found that crystalline forms of EtO2C—CH2—(R)Cgl-Aze-Pab-OH ha... | 05/03/2005 |
| 6864249 | Piperidine and azetidine thrombin inhibitors The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhib... | 03/08/2005 |
| 6855706 | Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin. ... | 02/15/2005 |
| 6852865 | Catalytic carbonylation of three and four membered heterocycles Epoxides, aziridines, thiiranes, oxetanes, lactones, lactams and analogous compounds are reacted with carbon monoxide in the presence of a catalytically effective amount of catalyst having the general formula [Lewis acid]z+{[QM(CO)x]w− | 02/08/2005 |
| 6835831 | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): The method comprises the step of reacting an aldehyde compound R10CHO with an isonitrile compound re... | 12/28/2004 |
| 6835727 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as... | 12/28/2004 |
