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Class 548/952 - Chalcogen bonded directly to ring carbon of the hetero ring


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium
No. of patents: 125
Last issue date: 03/13/2012


1        
NumberTitleIssue Date
8134014Preparation of uretdione polyisocyanates
The invention relates to the use of specific pyridines as catalysts for the dimerization of isocyanates (uretdione formation) and a process for preparing polyisocyanates having a high content of uretdione groups. ...
03/13/2012
8071788Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide
The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5 -difluorophenyl)methylsulfonamide. ...
12/06/2011
7803954Mandelic acid derivatives and their use as thrombin inhibitors
There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are ...
09/28/2010
7790907Method of producing a uretonimine-modified isocyanate composition
A method produces a uretonimine-modified isocyanate composition having increased low-temperature tolerance. The method comprises providing a first polyisocyanate composition having two or more isocyanate groups and comprising 4,4′-diphenylmethane diisocyanate (MDI...
09/07/2010
7714148Process for the preparation of liquid, storage-stable organic isocyanates containing carbodiimide and/or uretoneimine groups
The invention relates to a process for the preparation of liquid, storage-stable isocyanate mixtures of low color number and which contain carbodiimide (CD) and/or uretonimine (UI) groups, the isocyanate mixtures obtainable by this process, and to a process for the ...
05/11/2010
7652154Method and intermediates for the preparation of derivatives of N (1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide
The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide. ...
01/26/2010
7504523Uretonimine-modified isocyanate composition and method of forming the same
A uretonimine-modified isocyanate composition has reduced color. The uretonimine-modified isocyanate composition comprises a polyisocyanate composition having two or more isocyanate groups and comprising 4,4′-diphenylmethane diisocyanate (MDI) and a catalyst for c...
03/17/2009
7326796Fluorinated monomers, fluorinated polymers having polycyclic groups with fused 4-membered heterocyclic rings, useful as photoresists, and processes for microlithography
The present invention provides novel fluorine-containing copolymers which comprise at least one fluorinated olefin, at least one polycyclic ethylenically unsaturated monomer with a fused 4-membered heterocyclic ring and, optionally, other components. The copolymers ...
02/05/2008
7323532Low-viscosity radiation-curing and thermally curing polyisocyanates
The present invention concerns a process for producing low-viscosity polyisocyanates or secondary products thereof, which carry activated, radiation-curable double bonds and can optionally also cure thermally, and low-viscosity polyisocyanate mixtures or secondary p...
01/29/2008
7317112Catalysts for selective isocyanate dimerization
A method of dimerizing isocyanates using sulphonamide anions as a dimerization catalyst for the isocyanates and also to a process for preparing oligomeric isocyanates using such catalysts. ...
01/08/2008
7288537Azetidine derivatives as CCR-3 receptor antagonists
Compounds of formula I in free or salt form, wherein Ar, X, Y, R1, R2, R3, R5, m, n, p and q have the meanings as indicated in the specification, are useful for treatin...
10/30/2007
7256186Gamma secretase inhibitors
This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ...
08/14/2007
7232812Substituted azetidine compounds, their preparation and use as medicaments
The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals. ...
06/19/2007
7208602Gamma secretase inhibitors
This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ...
04/24/2007
7129233Mandelic acid derivatives and their use as thrombin inhibitors
There is provided a compound of formula I wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including pro...
10/31/2006
7126003Method for producing 2-azetidinone derivative
A process for producing a compound represented by the following formula (II) which comprises treating a compound represented by the following formula (I) (wherein R1, R2 and R3 represent each a specific substituent) with an enzyme ca...
10/24/2006
7087594Alkyl ether derivatives or salts thereof
An alkyl ether represented by the general formula: or its salt. This compound has activity to protect neurons, activity to accelerate nerve regeneration and activity to accelerate neurite extension and hence is u...
08/08/2006
7060817Sulfonamide anions as catalysts for NCO oligomerization
The present invention relates to the use of sulphonamide salts as catalysts for oligomerizing isocyanates and also to a process for NCO oligomerization using the catalysts of the invention. ...
06/13/2006
7056907Mandelic acid derivatives and their use as thrombin inhibitors
There is provided a compound of formula (1) and pharmaceutically-acceptable derivatives (including prodrugs) thereof. Which compound and derivatives are useful as, or are as useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, a...
06/06/2006
7030274Process for the production of carbodiimide modified organic isocyanates
The present invention relates to an improved process for the production of carbodiimide modified organic isocyanate, preferably a polymethylene polyphenylisocyanate, and most preferably diphenylmethane diisocyanate. This process includes (1) neutralizing acidic impu...
04/18/2006
6987158Polyadducts containing uretidone groups
Polyaddition compounds containing uretdione groups prepared by reacting uretdione polyisocyanates formed from diisocyanates having exclusively secondary- and/or tertiary-attached isocyanate groups with a molar fraction of isocyanurate structures, based on the sum of...
01/17/2006
6852865Catalytic carbonylation of three and four membered heterocycles
Epoxides, aziridines, thiiranes, oxetanes, lactones, lactams and analogous compounds are reacted with carbon monoxide in the presence of a catalytically effective amount of catalyst having the general formula [Lewis acid]z+{[QM(CO)x]w−
02/08/2005
6835727Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as...
12/28/2004
6833453Methods of producing oxazolidinone compounds
Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamin...
12/21/2004
6831078Azetidinecarboxamide derivatives for treating CNS disorders
A compound of formula (1) wherein R1 is aryl; and R2 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epi...
12/14/2004
6784161Method for the treatment or prevention of flavivirus infections using nucleoside analogues
The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable sa...
08/31/2004
6599894Amidinobenzylamine derivatives and their use as thrombin inhibitors
There is provided compounds of formula I ##STR1## wherein R1, R2, Y, R3 and R4 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, suc...
07/29/2003
6590098Method of preparing aliphatic polyisocyanates with uretdione, isocyanurate and iminooxadiazindione structures
The invention relates to a method of preparing an aliphatic polyisocyanate by conversion of an aliphatic diisocyanate to a polyisocyanates in the presence of a catalyst, wherein the catalyst contains a saline compound having 5 to 97.1 wt. % of a 1,2,3- an...
07/08/2003
6579995Process for phosphorylation and compounds produced by this process
The present invention is directed to improved processes for phosphorylation and compounds produced by the improved processes. The improved process for phosphorylating complex alcohols comprises the following steps: (a) forming an intimate mixture of one o...
06/17/2003
6514961Azetidinecarboxamide derivatives for the treatment of CNS disorders
A compound of formula (1): ##STR1## wherein R1 is aryl; and R2, R3, R4, R5 and R6 which may be the same or different are selected from H, alkyl and aryl; pharmaceutically acceptable additio...
02/04/2003
6509463Isocyanoalkylcarbonic acid derivatives, the reaction thereof in isocyanide multicomponent reactions to form sec-amido-alkylcarbonic acid derivatives, and those sec-amidoalkyl-carbonic acid derivatives
The present invention relates to compounds of the general formula I ##STR1## wherein A is a group of the formula ##STR2## and Z is an O or S atom, to the further processing thereof to form novel sec-amidoalkylcarbonic acid derivatives and to those se...
01/21/2003
6489503Storage stable methylene bis(phenylisocyanate) compositions
The present invention provides a liquid methylene bis(phenylisocyanate) composition including a high concentration of methylene bis(phenylisocyanate) which has an improved storage stability. The invention further provides a method of making the liquid met...
12/03/2002
6452003Process for preparing low-odor and storage-stable monomer-containing polyisocyanurates from isophorone diisocyanate
The present invention provides a process, which includes: partially trimerizing isophorone diisocyanate in the presence of a catalyst having the formula: [R--NX3 ].sym. Y.crclbar. wherein R and X are butyl groups and Y- i...
09/17/2002
6417373Preparations of azabicylobutane, precursors, and related compositions
New aza azetidinium sulfate compounds are described which can be intermediates in the preparation of azabicyclobutane....
07/09/2002
6403574Azetidinecarboxamide derivatives for treating CNS disorders
##STR1## A compound of formula (1), wherein: R1 is aryl; R2 is H, alkyl or aryl; and R3 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and the use of the compounds in therapy, particularly fo...
06/11/2002
6403573Compounds of azetidine and pyrrolidin
The invention relates to a compound having formula (I) wherein A is an optionally unsaturated 5- or 6-membered ring, which may comprise a heteroatom selected from N,O and S and which may be substituted with oxo or (1-6C) alkyl; R1, R2
06/11/2002
6380429Preparation of sulfonyl imine compounds
Disclosed is a process for the oxidation of sulfonamides to sulfonyl imines using chromium (IV) dioxide as the oxidant....
04/30/2002
6375926Labelled elastase inhibitors
A human leucocyte elastase (HLE) inhibitor labelled with a detector moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, is useful for the diagnostic imaging of sites of inflammation of infection in vivo, for labelling leu...
04/23/2002
6362359One-component thermoset coating compositions
The present invention relates to compounds containing modified hydrazide groups and corresponding to formula I ##STR1## wherein R represents the residue obtained by removing the isocyanate groups from a monomeric polyisocyanate, a polyisocyanate adduct or...
03/26/2002
6297343Powder coating crosslinking agents containing uretdione groups and free isocyanate
The present invention relates to polyaddition compounds, which are solid below 40° C. and liquid above 125° C., are prepared by the reaction of an isocyanate component containing uretdione groups with a polyol containing ester and/or carbonate groups, o...
10/02/2001
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