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| Number | Title | Issue Date |
| 7408071 | N-aryl pyrrolidine derivatives as beta-secretase inhibitors There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R... | 08/05/2008 |
| 7405262 | Preparation of functionalized anionic polymerization initiators A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound. ... | 07/29/2008 |
| 7381827 | Processes and intermediates The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof. ... | 06/03/2008 |
| 7235544 | 3-sulfonylamino-pyrrolidine-2-one derivatives as inhibitors of factor Xa The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 06/26/2007 |
| 7226917 | Derivatives of N-[phenyl(pyrrolidine-2-yl)methyl]benzamide and N-[(azepan-2-yl)phenylmethyl]benzamide, preparation, and use in treatment of schizophrenia Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic ... | 06/05/2007 |
| RE39667 | 3,3-Diphenylpropylamines, their use and preparation The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a terti... | 05/29/2007 |
| 7105507 | Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R | 09/12/2006 |
| 7005439 | Compounds The invention provides compounds of general formula (I) wherein m, n, Z1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification, process... | 02/28/2006 |
| 6943188 | Hydroxyalkyl compounds The invention provides compounds of general formula (I) wherein Q, R, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation, pharmaceutical com... | 09/13/2005 |
| 6923835 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres The invention relates to novel bis-para-phenylenediamine derivatives containing a pyrrolidyl group substituted with a cationic radical, to dye compositions containing them and to the process of dyeing keratin fibres using these compositions. The present inven... | 08/02/2005 |
| 6803462 | Process for synthesizing functionalized styrene monomer This invention discloses a rubbery polymer which is comprised of repeat units that are derived from (1) at least one conjugated diolefin monomer, and (2) at least one functionalized monomer having of the structural formula: ... | 10/12/2004 |
| 6770463 | Process for the preparation of chiral isofluoroenes There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention. ... | 08/03/2004 |
| 6753327 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: ... | 06/22/2004 |
| 6750337 | Couplers for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R5SO4 where the halogen is preferably Cl, Br or I; R, R | 06/15/2004 |
| 6608052 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceut... | 08/19/2003 |
| 6605670 | Resorcinolic derivatives and methods of making and using the same Methods of making low molecular weight methylene acceptors are provided. The methylene acceptors are prepared by reacting a polyhydric phenol with an aromatic olefinic compound in the presence of an acid catalyst, and then further reacting the products of... | 08/12/2003 |
| 6544982 | Thrombin receptor antagonists A thrombin receptor antagonist having the formula ##STR1## useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non... | 04/08/2003 |
| 6476063 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: ##STR1## ##STR2## wherein R1, R2, R3, R... | 11/05/2002 |
| 6417353 | Preparing amines Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing coppe... | 07/09/2002 |
| 6413987 | Dermal anesthetic agents The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as w... | 07/02/2002 |
| 6403585 | -and ଲ-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 06/11/2002 |
| 6391910 | Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: ##STR1## wherein R1, R2... | 05/21/2002 |
| 6380397 | Process for preparing 4-substituted-1H-indole-3-glyoxamides A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.... | 04/30/2002 |
| 6313132 | Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, whe... | 11/06/2001 |
| 6271395 | Substituted with an N-methyl benzene-acetamide and 1-pyrrolidinyl A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula ##STR1## wherein the substituents are defined as in the application having a strong affinity for optical receptors, central analgesi... | 08/07/2001 |
| 6211364 | Process for preparing indane-like compounds The present invention provides intermediate for the preparation of indane-like compounds which are useful for the modulation of a muscarinic receptor.... | 04/03/2001 |
| 6136803 | Antidepressants The present invention provides novel compounds such as certain aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake. The present invention also provides an improvement in the treatment ... | 10/24/2000 |
| 6118001 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF-mediated diseases, including degenerative diseases and certain cancers.... | 09/12/2000 |
| 6100428 | Nickel promoted guanylation of amines with isothioureas and thioureas An improved method for guanylating amines is provided. Broadly, the amines are reacted with a guanylating agent in the presence of a nickel catalyst. Preferably, the nickel catalyst comprises nickel in the zero oxidation state. Suitable nickel(0) catalyst... | 08/08/2000 |
| 6008377 | Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxyl)benzoyl]benzoyl]benzo[b]-thiophenes.... | 12/28/1999 |
| 5968968 | Diphenyl-cyclopropenes as selective K-agonists Diphenyl-cyclopropene derivatives, their nontoxic, pharmaceutically acceptable acid addition salts and compositions are kapa opiods useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irri... | 10/19/1999 |
| 5948809 | (-) cis-6(S)-phenyl-5(R)4-(2-pyrrolidin-1-yl ethoxy) phenyl!-5,6,7,8-tetrahydronaphthalen-2-ol-D-tartrate (-)Cis-6(S)-phenyl-5(R)-4-(2-pyrrolidin-1-yl ethoxy)phenyl!-5,6,7,8-tetrahydro-naphthalen-2-ol D-tartrate, pharmaceutical compositions comprising this compound, and an advantageous process for preparing the compound.... | 09/07/1999 |
| 5945443 | Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compound of formulae IV having the structure: ##STR1## wherein X9 ; R1, R2, R3... | 08/31/1999 |
| 5912343 | Tertiary amines containing side-chain organolithium structures and method for the preparation thereof A compound comprising at least one cyclic amine, having an organolithium side-chain, defined according to formula (I) ##STR1## wherein Z is a lithium atom (Li); R1 is selected from the group consisting of organic groups containing from 1 t... | 06/15/1999 |
| 5847159 | 1-ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same 1-ω-(3,4-Dihydro-2-naphthalenyl)alkyl!cyclic amine derivative of the formula (I): ##STR1## wherein R1 and R2 are H, halogen, OH, alkyl, alkoxy, hydroxymethyl, etc., or R1 and R2 combine to form meth... | 12/08/1998 |
| 5843983 | Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use Compounds of formula (I): ##STR1## wherein: R1 represents a saturated heterocyclic group attached to the bond or group represented by A through a ring carbon atom; R2a, R2b, R2c, R3a, R3b | 12/01/1998 |
| 5837717 | Hydroxamic acid anesthetic compounds A compound of the following formula: ##STR1## and its pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C2-4 alkenyl, C1-4 | 11/17/1998 |
| 5804595 | Kappa opioid receptor agonists The invention provides certain amino acid conjugates of substituted 2-phenyl-N-1-(phenyl)-2-(1-heterocycloalkyl- or heterocycloaryl-)ethyl!acetamides useful for selectively agonizing kappa opioid receptors in mammalian tissue.... | 09/08/1998 |
| 5792786 | Non-steroidal anti-inflammatory fatty acid conjugates and their therapeutic use thereof The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably non~steroidal anti~inflammatory agents which include a carboxy... | 08/11/1998 |
| 5756762 | (S)-4-amino-hepta-5,6-dienoic acid and intermediates therof The present invention relates to a novel enantiospecific processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and pharmaceutically acceptable salts thereof, which is useful as an irreversible inhibitor of GABA-T, to novel intermediates thereof, and ... | 05/26/1998 |
