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| Number | Title | Issue Date |
| 8188301 | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission The present invention relates to the use of compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically to the use of 3-disubstituted phenyl-1-pyrrolidinols fo... | 05/29/2012 |
| 7408071 | N-aryl pyrrolidine derivatives as beta-secretase inhibitors There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R... | 08/05/2008 |
| 7348356 | Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's dis... | 03/25/2008 |
| 7329634 | 3-Phenyl substituted 3-substituted-4ketolactams and ketolactones The invention relates to novel 3-phenyl-substituted, 3-substituted 4-ketolactams and -lactones of the formula (I) in which Q, W, X, Y, A, B and G are as defined in the disclosure, to proc... | 02/12/2008 |
| 7285565 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 10/23/2007 |
| 7250519 | Method for the production of arylamines The invention relates to a method for the production of tertiary amines by reaction of secondary amines with aromatics or heteroaromatics in the presence of a base, a nickel or palladium compound and one or several phosphines, dialkoxy-, and/or diaryloxyphosphines i... | 07/31/2007 |
| 7241795 | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each indep... | 07/10/2007 |
| 7235580 | Mitotic kinesin inhibitors The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which c... | 06/26/2007 |
| 7223796 | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention particularly relates to compounds of formula I, | 05/29/2007 |
| 7211696 | Antileishmanial dinitroaniline sulfanomides with activity against parasite tubulin Dinitroaniline compounds useful for the treatment of diseases caused by parasitic protozoa in subjects in need of such treatment. The compounds are particularly useful in the treatment of leishmaniasis. The compounds are preferably less cytotoxic to normal cells tha... | 05/01/2007 |
| 7202367 | Process for arylating or vinylating or alkynating a nucleophilic compound The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the inventio... | 04/10/2007 |
| 7148362 | Process for the preparation of enantiopure pyrrolidin-2-one derivatives The present invention relates to a process for the preparation of enantiopure intermediates useful in the synthesis of valuable pharmaceutically active compounds, e.g. MAOB inhibitors, and to novel intermediates of formulae I and II | 12/12/2006 |
| 7138423 | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists The present disclosure relates to chemical compounds and their use in treatment of human diseases. A particular embodiment relates to compounds of Formula (I) or an isomer, a pharmaceutically acceptable salts or solvates thereof or a pharmaceutically acceptable form... | 11/21/2006 |
| 7078535 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid The invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid, in which 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is reacted with ω-bromo-4-chloroacetophenone with formation of 6-(4-c... | 07/18/2006 |
| 7078404 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use The invention relates to acyl-3-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of formula I, in wh... | 07/18/2006 |
| 7074536 | Alkylenebisnaphtol derivative and charge control agent which consists of the same The present invention provides an alkylenebisnaphthol derivative represented by formula [I]: and a salt thereof. The compound of the present invention has an excellent triboelectric charge property and useful as ... | 07/11/2006 |
| 7034045 | Monofluoroalkyl derivatives The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ... | 04/25/2006 |
| 6960665 | Process for arylating or vinylating or alkynating a nucleophilic compound The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogent-containing organic derivatives. The arylating or vinylating or alkynating process of the inventi... | 11/01/2005 |
| 6949536 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ... | 09/27/2005 |
| 6946560 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react... | 09/20/2005 |
| 6923835 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres The invention relates to novel bis-para-phenylenediamine derivatives containing a pyrrolidyl group substituted with a cationic radical, to dye compositions containing them and to the process of dyeing keratin fibres using these compositions. The present inven... | 08/02/2005 |
| 6906203 | Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to ... | 06/14/2005 |
| 6821998 | Arylamines as inhibitors of chemokine binding to US28 Methods for treating CMV and CMV-related diseases are provided that use compounds having the formula: wherein the subscripts m and n are each independently integers from 1 to 2; and the R group... | 11/23/2004 |
| 6811573 | Dyes for keratin fibres containing 1,3-diamino-4-heteroarylbenzene derivatives and novel 1,3-diamino-4-heteroarylbenzene derivatives Colorants for keratin fibers containing 1,3-diamino-4-heteroarylbenzene derivatives of general formula (I) or the physiologically tolerated salts thereof as well as novel 1,3-diamino-4-heteroarylbenzene derivatives. | 11/02/2004 |
| 6762277 | Method of manufacturing N-carboxyamino acid anhydride and polyamino acid A method of manufacturing a new N-carboxyamino acid anhydride and polyamino acid using a simple process operation. The method for manufacturing N-carboxyamino acid anhydride comprising reacting α-amino acid with di-tert-butyltricarbonate. The method for manu... | 07/13/2004 |
| 6750337 | Couplers for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R5SO4 where the halogen is preferably Cl, Br or I; R, R | 06/15/2004 |
| 6727238 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi... | 04/27/2004 |
| 6699884 | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: ##STR1## wherein A, X, n, R1... | 03/02/2004 |
| 6696591 | Process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R1 is the OCOR3 group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid deriv... | 02/24/2004 |
| 6670471 | Process for synthesizing functionalized styrene monomer This invention discloses a rubbery polymer which is comprised of repeat units that are derived from (1) at least one conjugated diolefin monomer, and (2) at least one functionalized monomer having of the structural formula: ##STR1## wherein R represe... | 12/30/2003 |
| 6630504 | Phenoxyphenylheterocyclyl derivatives as SSRIs The invention provides compounds of general formula (I) wherein R1 is H or C1 -C6 alkyl; R2 and R3, together with the interconnecting atoms form a 4 to 8-membered saturated ring containing one or two ... | 10/07/2003 |
| 6608095 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: ##STR1## or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated five membered carbocyclic, w... | 08/19/2003 |
| 6605670 | Resorcinolic derivatives and methods of making and using the same Methods of making low molecular weight methylene acceptors are provided. The methylene acceptors are prepared by reacting a polyhydric phenol with an aromatic olefinic compound in the presence of an acid catalyst, and then further reacting the products of... | 08/12/2003 |
| 6521761 | Primary intermediates for oxidative coloration of hair Primary intermediates useful hair coloring systems comprise quaternized pyrrolidine compounds. The invention provides new quaternized pyrrolidine of Formula (1): ##STR1## wherein X is Cl, Br, I, or R3 S04 ; R is a C1 to C | 02/18/2003 |
| 6489480 | Group-15 cationic compounds for olefin polymerization catalysts This description addresses fluorinated amine compounds meeting the general formula R'i ArF--ER2, where ArF is a fluoroaryl group, E is nitrogen or phosphorous, each R is independently a C1 -C20 hydrocarbyl group... | 12/03/2002 |
| 6458965 | Aryl phenyl substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketonols of the formula (I) ##STR1## in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenylox... | 10/01/2002 |
| 6417353 | Preparing amines Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing coppe... | 07/09/2002 |
| 6417371 | Process for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-ac etic acid The present invention relates to a process process for the preparation of the compound of the formula I ##STR1## where the compound of the formula III ##STR2## is reacted with oxalyl chloride and the product obtained is treated with hydrazine and an ... | 07/09/2002 |
| 6417370 | Arylphenyl-substituted cyclic keto-enols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) ##STR1## in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogeno-alkoxy, halogenoalkenyl... | 07/09/2002 |
| 6380241 | Treatment of diseases using endothelin antagonists A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.... | 04/30/2002 |
