Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| RE39419 | Estrogen agonist/antagonist metabolites This invention relates to compounds that are mammalian metabolites of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol. The compounds of the invention can be used as standards for analytical assays or as intermediates fo... | 12/05/2006 |
| 6812244 | Naphthyl compounds, intermediates, compositions, and methods of use The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use. ... | 11/02/2004 |
| 6610705 | Process for the preparation of diaryl naphthyl methanes The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome, ##STR1## Pharmaceutical compositions comprising said nove... | 08/26/2003 |
| 6599920 | Naphthalene compounds, intermediates, formulations, and methods This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.... | 07/29/2003 |
| 6455572 | Estrogen agonist/antagonist metabolites This invention relates to compounds that are mammalian metabolites of (-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydr o-naphthalene-2-ol. The compounds of the invention can be used as standards for analytical assays or as interme... | 09/24/2002 |
| 6444688 | Compounds and compositions with nitrogen-containing non-basic side chains The instant invention provides compounds of formula I ##STR1## wherein R1 is OH, O--C(O)--(C1 -C6 alkyl), O--C(O)--O(C1 -C6 alkyl), O--C(O)--Ar, or O--C(O)--O--Ar; R2 is H, OH, O(C1 -... | 09/03/2002 |
| 6410564 | Naphthyl compounds, intermediates, processes, compositions, and methods The present invention provides a compound of formula I ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl) , --OCOC6 H5, --OCO(C1 -C6 alkyl), or --OSO2 (C4 -C | 06/25/2002 |
| 5998442 | Benzo [B] thiophene compounds, and compositions for treating bone loss, and hyperlipidemia The invention provides benzo[b]thiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions including hyperlipidemia and related cardiovascular pat... | 12/07/1999 |
| 5998401 | Naphthyl compounds, intermediates, compositions, and methods A class of substituted phenoxy naphthalene compounds of the structure: ##STR1## where n is 2 or 3; R1 is hydrogen, hydroxy, C1 -C4 alkoxy, phenoxycarbonyl, C1 -C6 alkoxycarbonyl, or C2 -C | 12/07/1999 |
| 5959103 | Naphthofluorene compounds, intermediates, compositions, and methods The invention provides naphthofluorene compounds, intermediates, formulations, processes, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia, and estr... | 09/28/1999 |
| 5952350 | Naphthyl compounds and compositions, as estrogen receptor binding agents The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions containing a compound of formula I, and methods of using a compound of formula I for inhibiting bone loss o... | 09/14/1999 |
| 5948809 | (-) cis-6(S)-phenyl-5(R)4-(2-pyrrolidin-1-yl ethoxy) phenyl!-5,6,7,8-tetrahydronaphthalen-2-ol-D-tartrate (-)Cis-6(S)-phenyl-5(R)-4-(2-pyrrolidin-1-yl ethoxy)phenyl!-5,6,7,8-tetrahydro-naphthalen-2-ol D-tartrate, pharmaceutical compositions comprising this compound, and an advantageous process for preparing the compound.... | 09/07/1999 |
| 5811421 | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods The present invention provides compounds of formula ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --OCOC6 H5, --OCO(C1 -C6 alkyl), or --OSO2 (C4 -C | 09/22/1998 |
| 5700947 | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation This invention is directed to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihydro-3H-pyrrolo1,2-a!pyrrole-1-carboxylic acid, 6-methoxy-2-napthylacetic acid, characterized in ... | 12/23/1997 |
| 5691353 | Method of inhibiting aortal smooth muscle cell proliferation using naphthyl compounds The present invention provides a compound of formula I ##STR1## wherein R1 is H, OH, halo, OCO(C1 -C6 alkyl), OCO(aryl), OSO2 (C4 -C6 alkyl), OCOO(C1 -C6 alkyl), ... | 11/25/1997 |
| 5484797 | Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis The present invention provides a compound of formula I ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --OCOC6 H5, --OCO(C1 -C6 alkyl), or --OSO2 (C4 -... | 01/16/1996 |
| 5484795 | Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis The present invention provides a compound of formula I ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --OCOC6 H5, --OCO(C1 -C6 alkyl), or --OSO2 (C4 -... | 01/16/1996 |
| 5484796 | Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation The present invention provides a compound of formula I ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --OCOC6 H5, --OCO(C1 -C6 alkyl), or --OSO2 (C4 -... | 01/16/1996 |
| 5272144 | Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is hydrogen or C1 -C6 alkyl;... | 12/21/1993 |
| 5250562 | Stilbene derivatives Compounds of the formula ##STR1## wherein R1 and R2 each independently are lower-alkyl; or together are alkylene with 3-5 C-atoms in a straight chain; one of the residues R3 and R4 is hydrogen and the other... | 10/05/1993 |
| 5149714 | Antidepressants The present invention provides novel aryloxy indanamines of the formula ##STR1## wherein n, p and q are each independently 0, 1 or 2, Y and X are each independently lower alkyl, lower alkoxy, hydroxy, CF3, halogeno or when p or q are 2 and each... | 09/22/1992 |
| 5145970 | Stabilizers derived from 3,5-dialkyl-4-aminobenzenethiol Compounds prepared by the addition of the mercaptan group of 3,5-dialkyl-4-aminobenzenethiol to activated ethylenic double bonds or the sulfenyl chloride of 3,5-dialkyl-4-aminobenzenethiol to trialkyl phosphites are effective stabilizers for organic mater... | 09/08/1992 |
| 5134240 | Bicyclic peroxides Novel 4-substituted-4,8-dimethyl-2,3-dioxabicyclo[3.3.1] nonan-7-ones which have a pronounced activity against the causative organism of malaria and can be used for the prevention and control of malaria.... | 07/28/1992 |
| 5128362 | 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes The present invention provides compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R1 is selected from hydrogen, halo, lower alkyl, lower alkoxy, or thioalkoxy; and R2 is lower alkoxy; or R | 07/07/1992 |
| 4996215 | Piperidine derivative and pharmaceutical composition containing the same A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, ... | 02/26/1991 |
| 4933346 | Diarylalkyl piperazine derivatives, a process for their preparation, their use, and medicaments containing them Compounds I are described ##STR1## with R1 equal to (cyclo)alk(en)yl or ##STR2## R2 /R3 equal to phenyl or phenylalkyl, A equal to ##STR3## m equal to 2-4, and n equal to 1-4. Compounds I and their salts ar... | 06/12/1990 |
| 4824968 | Substituted aromatic sulfonamides as antiglaucoma agents Aromatic sulfonamides with a saturated heterocycle fused thereto are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.... | 04/25/1989 |
| 4732896 | Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof, the process for preparing these derivatives and salts and the application thereof in therapeutics New aromatic derivatives having an activity antagonistic to calcium and corresponding to formula: ##STR1## in which: A represents a chain having any one of the following structures: ##STR2## Ar represents a group of structure: ##STR3## ... | 03/22/1988 |
| 4431851 | 3-(Hydroxyalkyl)-3,4-dihydro-1-orthohalophenyl naphthalenes The present invention concerns compounds of the formula ##STR1## wherein n=1, 2 or 3; and R' represents phenyl or orthofluorophenyl. Said compounds are used as intermediates in the preparation of heterocyclic aminoalkyl derivatives which are useful ... | 02/14/1984 |
| 4342762 | Basic ethers and pharmaceutical compositions containing the same The invention relates to novel basic ethers of the general formula /I/ and pharmaceutically acceptable acid addition salts and quaternary salts thereof, ##STR1## wherein R1 and R2 may be the same or different and represent a ... | 08/03/1982 |
| 4327214 | Substituted alkylammonium salts, the manufacture thereof, the use thereof for regulating plant growth, and agents therefor Substituted alkylammonium salts of the formula ##STR1## where R1, R2 and R3 are hydrogen, C1-4 -alkyl, fluorine, chlorine or bromine, X is oxygen or sulfur, n denotes one of the integers 2, 3 and 4, A denot... | 04/27/1982 |
| 4230862 | Antifertility compounds Derivatives of 3-phenyl-4-aroyl-1,2-dihydronaphthalenes and 1-aroyl-2-phenylnaphthalenes are useful both as antifertility agents and in suppressing the growth of mammary tumors.... | 10/28/1980 |
| 4170653 | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R1 is hydrogen or lower alkyl; and R2 and R3 together with the nitrogen atom to which they are joined form a heterocyclic ami... | 10/09/1979 |
| 4093631 | 7-Aminopropoxy chromane and chromenes Compounds of the formula (I): ##STR1## and salts thereof wherein R1 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl; R2 is hydrogen or alkyl of 1 to 4 carbon atoms or is joined to R1 so that the NR1 R | 06/06/1978 |
| 4079066 | 4-Naphthyl derivatives of 7-aminoalkylenoxy-2H-chromene Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein X is an alkylene group of 2 - 4 carbon atoms; Y is CH2 or 0; R1 is a hydrogen atom or a C1-6 alkyl group; R2 is a... | 03/14/1978 |
| 4075223 | Novel antifertility agents Derivatives of 2-aroyl-3-phenylindenes, 3-aroyl-4-phenyl-1,2-dihydronaphthalenes, and 1-phenyl-2-aroyl-naphthalenes are useful as antifertility agents.... | 02/21/1978 |
| 4072672 | Cationic dyes containing an aryloxy group linked through a bridging radical to a quaternized nitrogen atom Disclosed are basic dyes, e.g., azo dyes and anthraquinone dyes free from sulphonic acid groups and which contain, as characteristic group, a group of the formula ##STR1## in which R and R1, independently, are substituted or unsubstituted ... | 02/07/1978 |
| 4060613 | 3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R1 is hydrogen or lower alkyl; and R2 and R3 together with the nitrogen atom to which they are joined form a hyterocyclic ami... | 11/29/1977 |
| 4038274 | CNS active compounds Compounds of the formula ##STR1## wherein X, n and B are as defined herein are useful as intermediates in preparing compounds which exhibit antidepressant activity.... | 07/26/1977 |
| 3968218 | Cosmetic composition containing a hydroxylated amino thioether for application to the hair and skin A method and composition for combatting the greasy and unaesthetic appearance of the hair and to improve the appearance of the skin comprises in a carrier at least one active component of the formula ##EQU1## wherein R1 and R2 a... | 07/06/1976 |
