Class 548/569 - The nitrogen is in a substituent attached to the ring nitrogen of the five membered hetero ring

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the nitrogen is part of a substituent
No. of patents: 207
Last issue date: 09/09/2008

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Number	Title	Issue Date
7423059	Pharmaceutically active compounds and methods of use The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or p...	09/09/2008
7365070	Modulators of melanocortin receptor This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: ...	04/29/2008
7365196	Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ...	04/29/2008
7351825	Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1):	04/01/2008
7288566	N-hydroxyformamidine derivatives An N-hydroxyformamidine compound of the following formula or a pharmaceutically acceptable salt thereof: wherein R1, A and R are as defined herein. The compounds inhibit 20-HETE-producing enzymes, 20-H...	10/30/2007
7265228	Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. ...	09/04/2007
7256191	Materials and methods for the treatment of depression The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters within the structure of the compounds are taught. Also provided are metho...	08/14/2007
7026485	Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	04/11/2006
6919368	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ...	07/19/2005
6900243	Phenylheteroalkylamine derivatives There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their pre...	05/31/2005
6887872	Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suit...	05/03/2005
6878736	Histamine H3 receptor ligands Compounds of formula (I) (and pharmaceutically acceptable salts thereof) are histamine H3 receptor ligands. A in the formula represents (CH2)m, m being from 1 to 3; B is (CH2)n, n being from 1 to 3; x is from 0 ...	04/12/2005
6818715	Bisimidino compounds and the transitional metal complexes thereof as well as the use thereof as catalysts Bisimine compounds of the formula (I) where the symbols are defined in the specification are used to prepare bisimidinato complexes which can be used in the polymerization of unsaturated compounds. ...	11/16/2004
6624177	Matrix metalloproteinase inhibitors and their therapeutic uses The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I ##STR1## More particularly, the present invention relates to a method of treating dis...	09/23/2003
6608196	Process for solid supported synthesis of pyruvate-derived compounds Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis....	08/19/2003
6545037	Benzenesulfonamide compounds A compound of formula (I): ##STR1## which is useful as a TXA2 and 5-HT2 receptor and pharmaceutical compositions containing the same....	04/08/2003
6506759	Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease....	01/14/2003
6469011	Benzenesulfonamide compounds useful as TXA2 and 5-HT2 receptor antagonists Compound of formula (I): ##STR1## which is useful as a TXA2 and 5-HT2 receptor antagonist and pharmaceutical compositions containing the same....	10/22/2002
6436235	N-substituted perfluoroalkylated pyrrolidines and process for making them N-substituted perfluoroalkylated pyrrolidines of the formula III ##STR1## where RF, B, Q and q are as defined herein are prepared from diallylamine, a perfluoroalkyl iodide and an amino-reactive compound selected from the group of carboxylic ac...	08/20/2002
6413987	Dermal anesthetic agents The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as w...	07/02/2002
6399824	Substituted cinnamic, acid guanidides, process for their preparation, their use as a medicament, and medicament comprising them Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I ##STR1## which may be obtained by reaction of a compound II ##STR2## with guanidi...	06/04/2002
6395735	Pharmaceutical compounds The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using the novel compoun...	05/28/2002
6362230	Sulphonamide derivatives The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them....	03/26/2002
6342609	Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives A process for industrially preparing intermediates of aromatic amidine derivatives having anticoagulant activity, i.e., compounds represented by formula (3) or salts thereof, by the following reaction scheme including (1), (2), and (3), wherein R1	01/29/2002
6323223	Cyclic amine derivatives- CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds....	11/27/2001
6294569	Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists A compound of the following formula: ##STR1## and the salts thereof, wherein A is hydrogen, halo, hydroxy, or the like; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1	09/25/2001
6281211	Substituted semicarbazides and the use thereof This invention is related to substituted semicarbazides represented by Formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalky...	08/28/2001
6281206	Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically accepta...	08/28/2001
6255277	Localized use of nitric oxide-adducts to prevent internal tissue damage A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide ...	07/03/2001
6201007	Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists A compound of the following formula: ##STR1## and the salts thereof wherein A is hydrogen, halo, or hydroxy, broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is optional...	03/13/2001
6174922	Sulphonamide derivatives The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them....	01/16/2001
6159995	Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved....	12/12/2000
6110944	LTA₄, hydrolase inhibitors The present invention provides compounds having the structure Ar1 --Q--Ar2 --O--(CH2)n --Z and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which ar...	08/29/2000
6033446	Polyalkylpyrrolidines and fuel compositions containing the same A polyalklpyroroplidine compound of the formula: ##STR1## or a fuel-soluble salt thereof; wherein R1 is a polyalkyl group having an average molecular weight in the range of from about 500 to 5,000; R2 is a straight- or branched-...	03/07/2000
6017918	Phenyl glycine compounds and methods of treating atherosclerosis and restenosis The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions c...	01/25/2000
5998630	Carbodiimide coupling reagent The present invention relates to compounds used for increasing activation of the 5-HT1F receptor....	12/07/1999
5998399	Guanidine derivatives useful in therapy as inhibitors of nitric oxide synthetase Method of treating or reducing the risk of human disease or condition in which the synthesis or oversynthesis of nitric oxide forms a contributory part wherein a therapeutically effective amount of the compound of formula (I) as defined in the specificati...	12/07/1999
5955632	Seco-d steroids active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system. The seco-D steroid derivatives have the following general formula (I): ##STR1##...	09/21/1999
5925667	Pyrrolidine derivative, anti-ulcer drug, and antibacterial drug A pyrrolidine derivative or a salt thereof expressed by the following formula 1: ##STR1## wherein R1 is an alkenyl group; R2 is a lower alkoxy group or a halogen atom; R3 is a lower alkyl group; X is a group expressed...	07/20/1999
5922763	Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts the...	07/13/1999

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Class 548/569 - The nitrogen is in a substituent attached to the ring nitrogen of the five membered hetero ring