Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8119819 | Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of... | 02/21/2012 |
| 7615647 | Process for producing atorvastatin hemicalcium A process is provided for preparing pharmaceutical grade atorvastatin hemicalcium salt comprising: (a) deesterifying, wherein R is ... | 11/10/2009 |
| 7488832 | Azolylacylguanidines as β-secretase inhibitors The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tang... | 02/10/2009 |
| 7414142 | 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators Compounds of formula I, wherein R1-R9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, prov... | 08/19/2008 |
| 7410999 | Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.... | 08/12/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7314885 | Pyrrole compounds useful as kinase inhibitors The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatm... | 01/01/2008 |
| 7276612 | Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase... | 10/02/2007 |
| 7250444 | Pyrrole-based HMG-CoA reductase inhibitors HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided. ... | 07/31/2007 |
| 7241803 | Compounds for inhibition of HIV infection by blocking HIV entry A group of compounds that inhibit HIV replication by blocking HIV entry was identified. Two representative compounds, designated NB-2 and NB-64, inhibited HIV replication (p24 production) with IC50 values | 07/10/2007 |
| 7202368 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines A process for preparing an optionally substituted 4-benzimidazol-2-ylmethylamino)benzamidine, the process comprising: (a) condensing an optionally suitably substituted diaminobenzene with 2-[4-(1,2,4-oxadiazol-5-on-3-yl)phenylamino... | 04/10/2007 |
| 7186749 | Pyrrolo-naphthyl acids and methods for using them The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 03/06/2007 |
| 7179581 | Resist composition and patterning process Resist compositions comprising nitrogen heterocyclic compounds having a pyrrole or nitrogen-bearing 5-membered ring structure and a polar functional group have an excellent resolution and an excellent focus margin and are useful in microfabrication using electron be... | 02/20/2007 |
| 7138423 | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists The present disclosure relates to chemical compounds and their use in treatment of human diseases. A particular embodiment relates to compounds of Formula (I) or an isomer, a pharmaceutically acceptable salts or solvates thereof or a pharmaceutically acceptable form... | 11/21/2006 |
| 7109243 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present inven... | 09/19/2006 |
| 6969744 | Living and quasiliving cationic telechelic polymers quenched by N-substituted pyrrole and methods for their preparation Disclosed is a method of preparing terminally functionalized telechelic polymers using a cationic living polymer product or a terminal tert-chloride chain end of a carbocationic quasiliving polymer product, which comprises quenching the polymer product with an N-sub... | 11/29/2005 |
| 6933390 | Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur... | 08/23/2005 |
| 6911468 | Tyrosine phosphatase inhibitors A compound of the formula (I): wherein X1 and X2 are the same or different and each is a bond or a spacer having 1 to 20 atom(s) in the main chain; one of... | 06/28/2005 |
| 6864270 | Iron binding agents Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a therapeutically-effective amount of a compound of formula (I) or (IV), i.e. sufficien... | 03/08/2005 |
| 6723753 | Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle... | 04/20/2004 |
| 6677368 | 4-aryl substituted indolinones The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention a... | 01/13/2004 |
| 6649658 | (-)-Verbenone derivatives A description is given here of novel solid and stable derivatives of (-)-verbenone having formula (I) wherein, when X=O Z=H, .dbd.CHAr, .dbd.C(OH)COOEt, .dbd.NOR; Y=H, NH2, NH3 +X1 -, NHCOAr, NHCOR, NHCONHR, NHCONHAr, X | 11/18/2003 |
| 6632963 | Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## in which Ar1 is a radical having one of the structural formulae (a)-(c): ##STR2## Ar2 is a radical having one of th... | 10/14/2003 |
| 6603013 | Heterogeneously catalyzed process for cross coupling alkenyl halides with boronic acids The present invention relates to a process wherein heterogeneous finely-dispersed palladium catalysts are used in a cross-coupling reaction of alkenyl halides and aryl or heteroaryl boronic acids in the presence of base in an aprotic solvent to produce ar... | 08/05/2003 |
| 6579987 | Diaryl-enynes Provided, among other things, is a compound of Formula I: ##STR1## wherein: Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of a... | 06/17/2003 |
| 6576780 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 06/10/2003 |
| 6531472 | Tetralone derivatives The present invention provides compounds of formula I ##STR1## and pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, X and Y have the meanings defined in the specification. The compounds have histone deacetylase (HDAC) inhibitory activity whi... | 03/11/2003 |
| 6525085 | Diaryl-enynes Provided, among other things, is a compound of Formula I: ##STR1## wherein: Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of a... | 02/25/2003 |
| 6492413 | 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interes... | 12/10/2002 |
| 6489515 | Gas-phase dehydration reaction process Here is provided a process capable of efficiently carrying out a gas-phase dehydration reaction comprising contacting a raw material gas with a solid oxide catalyst containing an alkali metal element to allow reaction to progress by inhibiting decompositi... | 12/03/2002 |
| 6465471 | Cinnamic acid derivatives Compounds of formula (1) are described: ##STR1## in which Het is a heteroaromatic group, Alk1 is an optionally substituted aliphatic or heteroaliphatic chain and R is a carboxylic acid or a derivative thereof. The compounds are able to inhibit ... | 10/15/2002 |
| 6441177 | Tertiary amines Tertiary amines of the formula ##STR1## wherein A1, A2, A3, A4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.... | 08/27/2002 |
| 6417372 | Stable arylpyrrole particles, process for their preparation and suspension concentrate compositions comprising them The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surp... | 07/09/2002 |
| 6331636 | Therapeutically useful 2-aminotetralin derivatives This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of the formula ##STR1## These compounds are useful to treat central nervous system disorders, hypertension, diabetes, sexual impotency an... | 12/18/2001 |
| 6294568 | 5-arylpyrrole derivatives The present invention provides compounds represented by the general formula (I): ##STR1## and a salt thereof, and anti-inflammatory agents and antitumor agents containing the compounds as the active ingredients.... | 09/25/2001 |
| 6248765 | Imidazole derivatives as histamine receptor H3 (ANT) agonists Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, havi... | 06/19/2001 |
| 6242613 | Stable arylpyrrole particles, process for their preparation and suspension concentrate compositions comprising them The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surp... | 06/05/2001 |
| 6194599 | Process for preparing biaryl compounds The present invention provides a process for preparing biaryl compounds comprising reacting an arylzinc reagent with an arylchloride in the presence of a nickel catalyst or a palladium catalyst. The present invention specifically provides a process for th... | 02/27/2001 |
| 6162918 | Xanthene and acridine derivatives The invention relates to new and known tricyclic dione derivatives of the general formula ##STR1## and to their salts which are inhibitors of herpes simplex virus thymidine kinase in the treatment and prophylaxis of infections caused by herpes s... | 12/19/2000 |
| 6156784 | Compounds useful as phosphotyrosine mimics Disclosed are compositions containing compounds of the formula (I) below wherein A,B,C,G,Q and R are defined herein. The compounds are useful as phosphotyrosine mimics that, when incorporated into an appropriate molecular structure, inhibit the binding of... | 12/05/2000 |
