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| Number | Title | Issue Date |
| 8017790 | Method for producing pyrrolidones from succinates from fermentation broths The present invention relates to a process for preparing a compound II or a composition comprising the compound II to a composition comprising succinimide and to a composition prepared by the process according to the invent... | 09/13/2011 |
| 7498447 | Therapeutic compounds Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 03/03/2009 |
| 7482475 | Therapeutic lactams Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 01/27/2009 |
| 7476747 | Substituted gamma lactams as therapeutic agents A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compoun... | 01/13/2009 |
| 7329685 | 1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor Xa inhibitors for the treatment of acute vascular diseases The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 02/12/2008 |
| 7294649 | Methamphetamine derivatives and conjugates for immunoassay Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure wherein ... | 11/13/2007 |
| RE39744 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group... | 07/24/2007 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| 7198893 | DNA diagnostics based on mass spectrometry Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromo... | 04/03/2007 |
| 7179779 | Cationic bleach activator with enhanced hydrolytic stability A novel cationic bleach activator having an enhanced hydrolytic stability is provided. The novel cationic bleach activator also leads to a reduction in strength loss of cotton fibers compared to conventional hot peroxide bleaching, and achieves this reduction in str... | 02/20/2007 |
| 7144978 | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same Multi-armed functional polyethylene glycol polymers with active terminal groups may be used in conjugation with small molecule pharmaceuticals, proteins and peptides to enhance half-life and bioavailability of the drug and improve solubility, stability and immunolog... | 12/05/2006 |
| 7091285 | Adducts of mid-range vinylidene content polyisobutylene polymer products and methods for making the same A reaction product comprising an adduct of a mid-range vinylidene content PIB polymer composition and maleic anhydride, a phenolic compound or a compound having a reactive site for subsequent amination. The PIB composition comprises a relatively low molecular weight... | 08/15/2006 |
| 7084090 | Catalyst comprised of n-substituted cyclic imides and processes for preparing organic compounds with the catalyst A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable pr... | 08/01/2006 |
| 7078424 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 07/18/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 7030249 | Process for converting α-angelica lactone to 5-methyl-N-alkyl-2-pyrrolidone using alkyl amines This invention relates to a process for producing 5-methyl-N-alkyl-2-pyrrolidone by a) reacting α-angelica lactone with alkyl amines and b) hydrogenating the products of step (a) in the presence of a metal catalyst, which is optionally supported. ... | 04/18/2006 |
| 7018625 | Personal care compositions Personal care compositions, particularly hair care products, include a polymer mixture made from (A) a derivatized polymer of maleic anhydride having defined repeat units of a monomer (e.g. α-olefin) maleic anhydride alkyl half-ester or full acid, maleamic acid and... | 03/28/2006 |
| 7005125 | Personal care products Personal care products, particularly hair care products, are made herein by mixing (A) a polymer having defined repeat units of a monomer (e.g. α-olefin) maleic anhydride alkyl half-ester or full acid, maleamic acid and maleimide, which is derivatized with an amine... | 02/28/2006 |
| RE38934 | Method and reagents for N-alkylating ureides A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I with an alkylating agent of structure III in the presence of a basic catalyst in an... | 01/10/2006 |
| 6967107 | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the pr... | 11/22/2005 |
| 6960667 | Fluorescent maleimides and uses thereof The present invention is directed to maleimides and preparation of compounds of the formula I wherein R1 and R2 independently from each other stand for | 11/01/2005 |
| 6943179 | Biurethane derivatives Novel compounds of the formula I in which X, Y, Z, R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and... | 09/13/2005 |
| 6939993 | Method for separation of reaction products from catalysts Method for separating reaction product from imide compound catalyst represented by Formula (1) or derivative thereof in reaction mixture obtained by reaction in presence of imide compound catalyst: wherein R1 | 09/06/2005 |
| 6933390 | Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur... | 08/23/2005 |
| 6887952 | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the pr... | 05/03/2005 |
| 6858736 | Hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof The present invention relates to novel hexa-arm polyethylene glycol (6-arm PEG) and its derivatives. The core of 6-arm PEG derivatives is sorbitol and the end groups can be derivatized into many different reactive functionalities that are useful in conjugating with ... | 02/22/2005 |
| 6806287 | 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are par... | 10/19/2004 |
| 6620946 | Low shrinkage thermosetting resin compositions and methods of use thereof In accordance with the present invention, there are provided thermosetting resin compositions with a reduced propensity to shrink in volume upon cure and methods of use therefor. The compositions of the present invention include compounds having aromatic,... | 09/16/2003 |
| 6582928 | Carbohydrate-directed cross-linking reagents The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue allowing couplin... | 06/24/2003 |
| 6570024 | Process and intermediates Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.... | 05/27/2003 |
| 6528455 | Phenoxy-and thiophenoxy acrylic acid compounds as herbicides Phenoxy- and thiophenoxyacrylic acid compounds of the formula I ##STR1## in which Het, R1, R2, R3, V, W and Z are as defined in claim 1 and processes for their preparation, intermediates for their preparation, herbicidally... | 03/04/2003 |
| 6451736 | Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides compounds of the formula (I): ##STR1## wherein R1, R2, R3 and Z are as defined in the specification. The compounds are useful as herbicides.... | 09/17/2002 |
| 6437009 | Low foam n-alkyltartarimide and n-alkylmalimide wetting agents This invention provides water-based compositions, particularly coating, ink, fountain solution, adhesive, agricultural and electronics cleaning compositions, manifesting reduced equilibrium surface tension by the incorporation of a surface tension reducin... | 08/20/2002 |
| 6392104 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): ##STR1## wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or ... | 05/21/2002 |
| 6388094 | Method for making intermediates useful in synthesis of retroviral protease inhibitors A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.... | 05/14/2002 |
| 6365615 | Small molecules useful in the treatment of inflammatory disease Novel compounds of the formula I ##STR1## which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 2-(3,5-Dichlorophenyl)-7-(R*)-phenyl-7a-(R*)-tetrahydropyrrolo[1,2-c]imidaz ole-1,3-dione; 2-(3,5... | 04/02/2002 |
| 6352566 | Ethers of polyalkyl or polyalkenyl N-hydroxyalkyl succinimides and fuel compositions containing the same Ethers of polyalkyl or polyalkenyl N-hydroxyalkyl succinimides having the formula: ##STR1## or a fuel soluble salt thereof; wherein R is a polyalkyl or polyalkenyl group having an average molecular weight in the range of about 450 to about 5,000; n is an ... | 03/05/2002 |
| 6348600 | Methods for making optically active 3-aminopyrrolidine-2,5-dione derivative and optically active 3-aminopyrrolidine derivative A method for making an optically active 3-aminopyrrolidine-2,5-dione derivative represented by the formula (3) includes cyclizing an optically active asparagine ester derivative represented by the formula (1) or (2), or an acid salt thereof. A method for ... | 02/19/2002 |
| 6303795 | Succinimide-based surfactant suitable for soil remediation A surfactant which is the reaction product of a hydrocarbyl-substituted succinic anhydride or a reactive equivalent thereof with at least one water-dispersible amine-terminated poly(oxyalkylene), is effective for use in soil remediation.... | 10/16/2001 |
| 6277997 | Process for the preparation of chiral lactones The present invention relates to a process for the preparation of compounds of formula I ##STR1## wherein R1 and R2 are as defined in the specification as well as to the novel intermediates obtained by said process.... | 08/21/2001 |
