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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8138353 | Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. ... | 03/20/2012 |
| 7763738 | Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. ... | 07/27/2010 |
| 7378436 | Compounds A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein R1 is H, C1-6alkyl, —C(X)Y, C3-8cycloalkyl, aryl, het, aryl-C1-4alkyl ... | 05/27/2008 |
| 7378419 | 9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heter... | 05/27/2008 |
| 7365093 | Endothelin antagonists A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin. ... | 04/29/2008 |
| 7342114 | Podophyllotoxin derivatives 4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4′-demethylepipodophyllotoxin. The compounds are useful for treating cancer. ... | 03/11/2008 |
| 7329654 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their prepar... | 02/12/2008 |
| 7323464 | Pyridine and pyrimidine derivatives Compounds of formula (1) are described in which Ra and Rb is each independently a hydrogen atom or a group Rc, or Ra and Rb together form an oxo (═O) or thio (═S) group; X is a N atom or an optionally substi... | 01/29/2008 |
| 7312242 | Use of parthenolide derivatives as antileukemic and cytotoxic agents Compounds of the formula having anti-tumor activity, wherein R1 and R2 are as described herein ... | 12/25/2007 |
| 7265228 | Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. ... | 09/04/2007 |
| 7208512 | Benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma The present invention provides benzodifuran imidazoline derivatives and benzofuran imidazoline derivatives for lowering intraocular pressure and providing ocular neuroprotection. ... | 04/24/2007 |
| 7196205 | Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. ... | 03/27/2007 |
| 7186722 | 2-heteroaryl-3,4-dihydro-2h-pyrrole derivatives and the use thereof as pesticides Novel Δ1-pyrrolines of the Formula (I) in which R1, R2, R3 and Het have the meanings given in the description, a plurality of processes for prep... | 03/06/2007 |
| 7169907 | Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, re... | 01/30/2007 |
| 7160877 | Aliphatic nitrogen-containing 5-membered ring compound The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—, ... | 01/09/2007 |
| 7157124 | Polymerizable compounds and their polymers A compound represented by formula (1) or (2) and a polymer obtained by polymerizing the compound are provided: wherein Ra is one of the groups represented by Formulas (3-1) to (3-5); Rb is h... | 01/02/2007 |
| 7148365 | Process for preparing 5-bromo-2,2-difluorobenzo-1,3-dioxoles The invention relates to a process for preparing 5-bromo-2,2-difluorobenzo-1,3-dioxoles and to the use thereof for preparing medicaments and crop protection agents. ... | 12/12/2006 |
| 7148242 | N-formyl hydroxylamine compounds, compositions and methods of use N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes or imidazacyclo4-7alkanes have interesting properties, e.g., in the treatment or prevention of disorders ... | 12/12/2006 |
| RE39420 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses Compounds of formula (I) and (II): [wherein R is hydrogen, halogen or alkyl; R1 is alkyl, amino or substituted amino; R2 is optionally substituted phenyl; R3 is hydrogen, halogen or optionally sub... | 12/05/2006 |
| 7138426 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 11/21/2006 |
| 7060725 | Substituted sulfamate anticonvulsant derivatives The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as descr... | 06/13/2006 |
| 7041831 | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): The method comprises the step of reacting an aldehyde compound R10CHO with an isonitrile compound rep... | 05/09/2006 |
| 7037669 | Assays for amphetamine and methamphetamine using stereospecific reagents Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/... | 05/02/2006 |
| 7022492 | Ecstasy haptens and immunogens Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a methylenedioxymethamphetamine. Immunogenic conjugates of Formula I ar... | 04/04/2006 |
| 6991911 | Assay for entactogens Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA)... | 01/31/2006 |
| 6962942 | Azacycloalkanone serine protease inhibitors The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds having F... | 11/08/2005 |
| 6960667 | Fluorescent maleimides and uses thereof The present invention is directed to maleimides and preparation of compounds of the formula I wherein R1 and R2 independently from each other stand for | 11/01/2005 |
| 6906098 | Mixed steroidal 1,2,4,5-tetraoxane compounds and methods of making and using thereof Disclosed herein are mixed steroidal tetraoxanes having the following structural formula 1 wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or isopropyl; R2 is H, methyl, or ... | 06/14/2005 |
| 6903116 | Methods of treating cancer using a heat shock factor activity inhibitor A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, whi... | 06/07/2005 |
| 6900227 | Benzodioxole derivatives The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective mo... | 05/31/2005 |
| 6890949 | Amino ceramide-like compounds and therapeutic methods of use Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase i... | 05/10/2005 |
| 6887893 | Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia. ... | 05/03/2005 |
| 6867230 | Hygromycin A derivatives This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3 and R10 | 03/15/2005 |
| 6855830 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. ... | 02/15/2005 |
| 6849639 | Integrin inhibitors and their methods of use The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as a αvβ3, α | 02/01/2005 |
| 6838478 | Amino acid derivatives and their use as thrombin inhibitors There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like... | 01/04/2005 |
| 6784167 | 17-beta-hydroxysteroid dehydrogenase-II inhibitors 17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group —C(R4)(R6)Y are oriented cis to each other; W represents O or S; R... | 08/31/2004 |
| 6750213 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 06/15/2004 |
| 6747160 | 1,2-Dioxetane derivatives and reagents employing them A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, ... | 06/08/2004 |
| 6673829 | Aminoazetidine,-pyrrolidine and -piperidine derivatives Novel aminoazetidine, -pyrrolidine, and -piperidine derivatives, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compoun... | 01/06/2004 |
