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| Number | Title | Issue Date |
| 7893280 | 2,4-disubstituted thiazolyl derivatives This invention concerns the use of a compound of formula (I′) a N-oxide, pharmaceutically acceptable addition salt, quaternary amine and stereochemically isomeric form thereof, wherein Q is optionally substituted C | 02/22/2011 |
| 7667047 | Colorant A colorant contains a crystal of a compound represented by the following formula (1): the crystal having a crystal form showing main peaks at interplanar spacings d of 3.45±0.5 Å, 3.63±0.5 Å, 4.23±0.5 Å, 6.65±0.5 ... | 02/23/2010 |
| 7442807 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n w... | 10/28/2008 |
| 7435833 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme A compound of formula (I): or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Methods of inhibiting 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. Methods of treating non-insul... | 10/14/2008 |
| 7425633 | Pyrrolidine compounds A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, T, X, Y, and Z are as defined herein. Also disclosed is a ... | 09/16/2008 |
| 7417062 | Substituted arylamides Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer. ... | 08/26/2008 |
| 7414359 | Low work function metal complexes and uses thereof The present invention provides conductive metal-ligand coordination complexes that are useful in a variety of electronic devices. For example, such complexes are useful in organic light emitting devices composed of one or more layers of organic material between two ... | 08/19/2008 |
| 7402262 | Electroconductive polymers Provided are novel polymerizable monomers allowing preparation of exceptionally useful surface coatings by polymerization. Embodiments include highly reticulated chiral nanoparticles useful, for example, for covalently grating biological ligands, epitaxial growth of... | 07/22/2008 |
| 7399748 | Antitumor therapy comprising distamycin derivatives The present invention relates to an administration schedule comprising the intravenous administration of a α-halogen-acryloyl distamycin derivative, or a pharmaceutically acceptable salt thereof. The above administration allows the treatment of a variety of tumors ... | 07/15/2008 |
| 7396851 | Heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of β-thalassaemia The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a medicament for the therapeutic treatment of β-thalassaemia. ... | 07/08/2008 |
| 7393846 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 07/01/2008 |
| 7388007 | Gamma-lactams as beta-secretase inhibitors There is provided a series of novel substituted gamma-lactams of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5 and R6 | 06/17/2008 |
| 7385084 | Bis(thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are inde... | 06/10/2008 |
| 7381741 | 3-amino-2-phenylpyrrolidine derivatives 3-amino-2-phenylpyrrolidine compounds useful as NK-1 antagonists, with pharmaceutical compositions and methods of treatment comprising same, are disclosed. ... | 06/03/2008 |
| 7378436 | Compounds A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein R1 is H, C1-6alkyl, —C(X)Y, C3-8cycloalkyl, aryl, het, aryl-C1-4alkyl ... | 05/27/2008 |
| 7371767 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 Pyrrole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, ... | 05/13/2008 |
| 7365092 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they ac... | 04/29/2008 |
| 7348346 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, sy... | 03/25/2008 |
| 7348347 | Substituted 4,5,6,7-tetrahydrobenzthiazol-2-ylamine compounds Substituted 4,5,6,7-tetrahydrobenzothiazol-2-ylamine compounds, a method for their production; pharmaceutical compositions comprising them, and methods of use for modulating biological functions and/or treating or inhibiting various medical conditions such as, e.g.,... | 03/25/2008 |
| 7338947 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma, pro... | 03/04/2008 |
| 7329765 | Benzothiophene compounds having antiinfective activity Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity. ... | 02/12/2008 |
| 7319098 | 1,3-dioxoisoindole derivatives having selective antagonism of T-type calcium channel The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of... | 01/15/2008 |
| 7314885 | Pyrrole compounds useful as kinase inhibitors The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatm... | 01/01/2008 |
| 7312218 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or hetero... | 12/25/2007 |
| 7309800 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/18/2007 |
| 7304165 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids Disclosed are cyclic imino oligomers and polymers comprised of subunits of the formula: Also disclosed are combinatorial libraries and arrays of the cyclic imino compounds. ... | 12/04/2007 |
| 7304087 | 1-acyl-pyrrolidine derivatives for the treatment of viral infections Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or o... | 12/04/2007 |
| 7291746 | Process for obtaining an antiepileptic agent A process for obtaining the pharmaceutical active ingredient, levetiracetam, by means of deaminomethylation of a sufficiently pure enantiomer intermediate (S)-(II), or by means of deaminomethylation of an addition salt thereof with an acid, wherein R1 and... | 11/06/2007 |
| 7276531 | G-lactam derivatives as prostaglandin agonists A gamma-lactam diene of Formula I: which is particularly useful as a medicament for the treatment of various disorders such as asthma, hypertension, osteoporosis, sexual dysfunction and fertility disorders. ... | 10/02/2007 |
| 7271172 | Pyrrolidine and azetidine compounds as CCR5 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an... | 09/18/2007 |
| 7262307 | 1′-benzyl-3-bromo-[1,3′]bipyrrolidinyl-2-one The compound (R)-(1′-benzyl-3-bromo-[1,3′]bipyrrolidinyl-2-one) which is an intermediate for antibacterial vinylpyrrolidinone-cephalosporin derivatives. ... | 08/28/2007 |
| 7262207 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and v... | 08/28/2007 |
| 7253205 | Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a variety of substituents, ring A i... | 08/07/2007 |
| 7250444 | Pyrrole-based HMG-CoA reductase inhibitors HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided. ... | 07/31/2007 |
| 7247735 | Octupolar molecules used as organic semiconductors In the case of the materials according to the invention, the charge carrier mobility in the correspondingly prepared films is achieved if the molecules are composed in such a way that side chains—consisting of conjugated aromatic or heteroaromatic systems—are at... | 07/24/2007 |
| 7238725 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... | 07/03/2007 |
| 7235544 | 3-sulfonylamino-pyrrolidine-2-one derivatives as inhibitors of factor Xa The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 06/26/2007 |
| 7235579 | Phosphodiesterase 4 inhibitors Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of... | 06/26/2007 |
| 7230024 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein. ... | 06/12/2007 |
| 7229991 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides 5-aminomethyl-1H-pyrrole-2-carboxylic acid amide compounds corresponding to formula I and processes for the production thereof. Pharmaceutical preparations containing these compounds and the use of these compound... | 06/12/2007 |
