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| Number | Title | Issue Date |
| 8158807 | Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds utilizing bisulfite intermediate The present invention provides for a process for preparing 6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate, an intermediate useful in the efficient preparation of (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylic acid and esters and salts the... | 04/17/2012 |
| 7544815 | Process for making hydroisoindoline tachykinin receptor antagonists The present invention is directed to a process for preparing certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of cer... | 06/09/2009 |
| 7388027 | Bicyclic compounds as modulators of androgen receptor function and method The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for examp... | 06/17/2008 |
| 7375237 | Pyrrolizine compounds useful as anti-inflammatory agents Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R | 05/20/2008 |
| 7345083 | Hydroisoindoline tachykinin receptor antagonists The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations compris... | 03/18/2008 |
| 7217731 | Hydroisoindoline tachykinin receptor antagonists The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations compris... | 05/15/2007 |
| 7098229 | (+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions and uses thereof The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and metho... | 08/29/2006 |
| 7094800 | Cyanopyrrolidides, process for their preparation and their use as medicaments The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts, physiologically functional de... | 08/22/2006 |
| 7078534 | Process for the preparation of crystalline N-formimidoyl thienamycin monohydrate (imipenem monohydrate) The present invention relates to a cost effective and commercially viable process for the preparation of crystalline N-formimidoyl thienamycin monohydrate (Imipenem monohydrate) of Formula I. ... | 07/18/2006 |
| 7060843 | Electroluminescent devices comprising diketopyrrolopyrroles Electroluminescent device comprising in this order (a) an anode (b) a hole transporting layer (c) a light-emitting layer (d) optionally an electron transporting layer and (e) a cathode and a light-emitting substance, wherein the li... | 06/13/2006 |
| RE39128 | Pleuromutilin derivatives as antimicrobials The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy. ... | 06/13/2006 |
| 7005439 | Compounds The invention provides compounds of general formula (I) wherein m, n, Z1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification, process... | 02/28/2006 |
| 6900322 | Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate produ... | 05/31/2005 |
| 6878738 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use The present invention relates to compounds of the formula I in which one of the radicals R8 and R9 is a hydrogen atom or an alkyl group and the other is hydroxyl, alkoxy or acyloxy or where R8 and R9, together with the... | 04/12/2005 |
| 6482957 | Cyclopentenecarboxamide derivative, method for preparing the same and bicycloamide derivative used therein A cyclopentenecarboxamide derivative represented by the formula (I): ##STR1## and a method for preparing the cyclopentencarboxamide derivative. A bicycloamide derivative represented by the formula (II): ##STR2## and a method for preparing the bicycloamide... | 11/19/2002 |
| 6395766 | Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition Compounds according to Formula (I) or a pharmaceutically acceptable salt thereof are GABA-A Alpha 5 ligands useful for enhancing cognition: ##STR1## where A is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloa... | 05/28/2002 |
| 6355668 | Bicycloloactam compounds, use thereof and intermediates for preparing thereof A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and... | 03/12/2002 |
| 6353109 | Certain fused pyrrolecarboxamides; a new class of GABA brain receptor Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: W represents substituted or unsubstituted aryl or heteroaryl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alky... | 03/05/2002 |
| 6316486 | Alkyl dihalogenated phenyl-substituted ketoenols useful as pesticides and herbicides The present invention relates to new compounds of the formula (I) ##STR1## in which X represents halogen, Y represents halogen or alkyl and Z represents halogen or alkyl, with the proviso that always one of the radicals Y and Z represents halogen while the oth... | 11/13/2001 |
| 6291507 | Chemical compounds A pharmaceutical composition which comprises a compound of formula (I) ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1, and wherein A and B form an optionally substituted ... | 09/18/2001 |
| 6288104 | Pharmaceutical compositions containing mesembrine and related compounds There is disclosed the use of mesembrine and related compounds (e.g. mesembranol, mesembranone) as scrotonin-uptake inhibitors, pharmaceutical compositions comprising such compounds or dry material or an extract of plants from the Mesembryanthemaceae fami... | 09/11/2001 |
| 6245919 | Cyclopropylglycine derivatives and agonists for metabotronic L-glutamate receptors A cyclopropylglycine derivative having the following formula: ##STR1## and an intermediate compound for the synthesis of the cyclopropylglycine derivative are novel compounds. The cyclopropylglycine derivative shows a selectivity higher than that of the k... | 06/12/2001 |
| 6232473 | Process for producing 2-azabicyclo[2.2.1]hept-5-en-3-one 2-Azabicyclo[2.2.1]hept-5-en-3-one is prepared by a process comprising: continuously mixing a substituted sulfonyl cyanide represented by formula (I): R--SO2 CN (I), wherein R represents an alkyl group or a phenyl group or a substituted phenyl grou... | 05/15/2001 |
| 6229011 | N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 05/08/2001 |
| 6211377 | Process for the purification of (&#b1;)-2-azabicyclo[2.2.1]hept-5-en-3-one A process for the purification of (&#b1;)-2-azabicyclo[2.2.1]hept-5-en-3-one wherein the purification is obtained exclusively by means of extraction procedures.... | 04/03/2001 |
| 6153765 | Process for producing and method of crystallizing 2-azabicyclo(2.2.1)hept-5-en-3-one A process for producing 2-azabicyclo[2.2.1]hept-5-en-3-one is provided by reacting a sulfonyl cyanide represented by the general formula R--SO2 CN (in which R represents an alkyl group or a phenyl group which may have a substituent), in the pre... | 11/28/2000 |
| 6133305 | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity The present invention relates to novel 3-(substituted)-2-indolinones compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment... | 10/17/2000 |
| 6121306 | Method of making (1S, 4R)-1-azabicyclo[2.2.1]heptan-3-one and (1R, 4S), 1-azabicyclo[2.2.1]heptan-3-one Racemic (&#b1;)-1-azobicyclo[2.2.1]heptan-3-one may be efficiently resolved into its (1S,4R)- and (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one isomers by formation of di-p-toluoyl hemitartrate salts by combination with di-p-toluoyl-L-tartaric acid and di-p-tol... | 09/19/2000 |
| 6107491 | Polymerizable diketopyrrolopyrroles Diketopyrrolopyrroles of formula I ##STR1## wherein R1 is a radical of formula II --Y--X--Z--Q (II), wherein Y is --CR3 R4, --SO2 --, --CO--, --Si(Hal)2 --, ... | 08/22/2000 |
| 6096887 | Certain fused pyrrolecarboxamides; a new class of GABA brain receptor ligands The present invention encompasses structures of the formula I: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## W represents substituted or unsubstituted heteroaryl; X is hydrogen, hydroxy or lower alkyl; T i... | 08/01/2000 |
| 6071908 | Radiation-activated cytotoxin therapy of neoplastic disease A method of treating neoplastic disease wherein a patient in need of such treatment is administered an effective amount of a radiation-activated cytotoxin prodrug (RACP) which has low toxicity, which is reducible by reducing agents generated by the radiol... | 06/06/2000 |
| 6060609 | Process for producing and method of crystallizing 2-azabicyclo[2.2.1]hept-5-en-3-one A process for producing 2-azabicyclo[2.2.1]hept-5-en-3-one is provided by reacting a sulfonyl cyanide represented by the general formula R-SO2 CN (in which R represents an alkyl group or a phenyl group which may have a substituent), in the pres... | 05/09/2000 |
| 6054464 | Azabicyclic esters of carbamic acids useful in therapy A compound of formula ##STR1## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C--R4 ; R1 is hydrogen or methyl; R2 is... | 04/25/2000 |
| 6037361 | Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase)... | 03/14/2000 |
| 5998429 | Azabicyclic esters of carbamic acids useful in therapy A compound of formula ##STR1## wherein: A is ##STR2## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C-R4 ; R1 is hydr... | 12/07/1999 |
| 5972248 | Stabilizers based on 1-aza-2,2,6,6 tetramethybicyclo [3.1.0]hexane The present invention relates to novel stabilizers of the formula (I) ##STR1## in which the substituents have the meaning defined in the description. These novel stabilizers are particularly suitable for stabilizing organic material, such as plastics... | 10/26/1999 |
| 5969154 | Liquid crystalline diketopyrrolopyrroles A liquid crystalline compound of formula ##STR1## wherein B and D are each independently of the other C6 -C24 alkyl, ##STR2## L is ##STR3## methyl or C10 -C18 alkyl, wherein R1 is ... | 10/19/1999 |
| 5958943 | A!-anellated pyrrole derivatives and their use in pharmacology The present invention relates to heterocyclic compounds of the formula ##STR1## in which R1 -R7, B, a and X have the meanings recited in the specification. These compounds are usable in the treatment of diseases of the rheumatoi... | 09/28/1999 |
| 5942535 | a!-Annelated pyrrole derivatives and pharmaceutical use thereof The present invention relates to heterocyclic compounds of the formula ##STR1## in which R1 -R7, B, a and X have the meanings recited in the specification. These compounds are usable in the treatment of diseases of the rheumatoi... | 08/24/1999 |
| 5919790 | Hydroxamate inhibitors of interleukin-1ଲ converting enzyme The present invention relates to compounds that are inhibitors of interleukin-1ଲ converting enzyme that have the Formula II ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusio... | 07/06/1999 |
