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| Number | Title | Issue Date |
| 8129546 | Derivatives for modulation of ion channels Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions. ... | 03/06/2012 |
| 7999119 | Compounds having CRTH2 antagonist activity Compounds of general formula (I) wherein R is phenyl optionally substituted with one or more halo substituents; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment o... | 08/16/2011 |
| 7799933 | Sulfonamide derivatives The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R1, R2, R3, X and Y are as defined in the description and in the claims, as well as physiologically accep... | 09/21/2010 |
| 7632956 | Fragrance ingredients, applications, compositions and methods The use of indole carbamates as fragrance ingredients and fragrance applications comprising indole carbamates in an effective amount. ... | 12/15/2009 |
| 7405236 | Indole derivatives comprising an acetylene group This invention is directed to compounds of the formula (I): wherein one of R6, R7, R8 and R9 is and X, R1 to R12,... | 07/29/2008 |
| 7365061 | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 04/29/2008 |
| 7355054 | Indole derivatives The invention relates to 1-(R1)-2-(R2)-3-(Y—X—NH-A- or Z-A-)-4,5,6,7-R)0-4-indoles, and their acid addition salts where the compounds are basic, wherein A is C1-4 alkylene, X is >CH2, >C═O or >C═S, and t... | 04/08/2008 |
| 7351719 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t... | 04/01/2008 |
| 7226942 | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 06/05/2007 |
| 7223786 | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 05/29/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7214704 | 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 05/08/2007 |
| 7173129 | Sulfonamide-substituted chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ... | 02/06/2007 |
| 7105564 | Pharmaceutical composition comprising a dual antagonist against PGD/TXAreceptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D2 receptor and pharmaceutical compositions comprising them. A compound of the formula (I): | 09/12/2006 |
| 7074782 | Carbamate caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electron... | 07/11/2006 |
| 6946547 | Ecstasy-class analogs and use of same in detection of ecstasy-class compounds The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class drugs. These analogs are compounds, or salts thereof, of a 2-amino-methyle... | 09/20/2005 |
| 6939889 | Quarternary ammonium compounds Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans. ... | 09/06/2005 |
| 6794406 | Indole derivatives The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments. ... | 09/21/2004 |
| 6759427 | Synthesis and methods of use of tetrahydroindolone analogues and derivatives A tetrahydroindolone derivative or analogue comprises a 9-atom bicyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety of the structure N(Y1)-D, where Y1 can be one ... | 07/06/2004 |
| 6656711 | Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothil... | 12/02/2003 |
| 6656961 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present inve... | 12/02/2003 |
| 6566533 | Method of producing heterocylic carbamates from aza-heterocyclic compounds and carbon dioxide The invention relates to a method of producing heterocyclic carbamates of the general formula (I) by reacting aza-heterocyclic compounds with alkyl- or aryl-halides in the presence of carbon dioxide and alkali carbonate, and to new compounds of the genera... | 05/20/2003 |
| 6525083 | N-substituted indoles useful in the treatment of diabetes Certain N-substituted indoles having aryloxyacetic acid, substituents are agonists or partial agonists of PPAR gamma, and are useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, h... | 02/25/2003 |
| 6500669 | Programmable genotoxic agents and uses therefor The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts dam... | 12/31/2002 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6489475 | Method of producing heterocyclic derivatives Heterocyclic derivatives of the formula (I) ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and method of producing them. Pharmaceutical compositions containing the heterocyclic derivative or a ph... | 12/03/2002 |
| 6482859 | Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsu... | 11/19/2002 |
| 6414008 | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions New disubstituted bicyclic heterocycles of general formula Ra --A--Het--B--Ar--E (I) Compounds of general formula I, wherein E is an Rb NH--C(.dbd.NH)-- group, have valuable pharmacological properties, particularly a thrombin-inhibiting ... | 07/02/2002 |
| 6388095 | Indole-containing quaternary ammonium compounds Compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.... | 05/14/2002 |
| 6380227 | Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothil... | 04/30/2002 |
| 6350777 | Description anti-mitotic agents which inhibit tubulin polymerization Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described. Additional aspects described here ar... | 02/26/2002 |
| 6323235 | Benzene-condensed heterocyclic derivatives and their uses Novel compounds having strong TXA2 receptor antagonist activities and PGI2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA2, are disclosed. The compound of the present... | 11/27/2001 |
| 6316630 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are int... | 11/13/2001 |
| 6291508 | Mono- or polyenic carboxylic acid derivatives Mono- or polyenic carboxylic acid derived compounds of the formula (1-I) or a physiologically acceptable salt thereof: Z--(CR3.dbd.CR.sup.2)n --COOR1 (1-I) wherein R1 is hydrogen or a carboxyl-protecting group; R2 | 09/18/2001 |
| 6288063 | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)x A--B--D--E--G whe... | 09/11/2001 |
| 6277849 | N-sulphonyl and N-sulphinyl amino acid amides as microbiocides The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsubs... | 08/21/2001 |
| 6245761 | Indolyl neuropeptide Y receptor antagonists This invention provides a series of substituted indoles which are useful in treating or preventing a condition associated with an excess of neuropeptide Y. This invention also provides the novel substituted indoles as well as pharmaceutical formulations w... | 06/12/2001 |
| 6242637 | Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH2 | 06/05/2001 |
| 6242609 | Method for manufacturing a color coupler used in a silver halide photographic light-sensitive material A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of ... | 06/05/2001 |
| 6214790 | Neo-tryptophan The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and... | 04/10/2001 |
