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| Number | Title | Issue Date |
| 8071786 | Indole compounds useful as serotonin selective agents Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds. ... | 12/06/2011 |
| 8034960 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as cPLAinhibitors The present invention provides a compound of formula 1: wherein R1 is CF3, R2 is H′ R3 is H. ... | 10/11/2011 |
| 7709661 | Synthetic methodology for the reductive alkylation at the C-3 position of indoles A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles th... | 05/04/2010 |
| 7365091 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful fo... | 04/29/2008 |
| 7365061 | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 04/29/2008 |
| 7288553 | Indole derivatives as selective androgen receptor modulator (SARMS) The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... | 10/30/2007 |
| 7276518 | Substituted cyclohexane-1,4-diamine compounds Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds. ... | 10/02/2007 |
| 7226942 | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 06/05/2007 |
| 7223786 | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 05/29/2007 |
| 7214704 | 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 05/08/2007 |
| 7166622 | Substituted phenylsulfonamide inhibitors of beta amyloid production Compounds of Formula I, wherein R1–R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs ther... | 01/23/2007 |
| 7115753 | Triaryl cation antibiotics from environmental DNA Disclosed are triaryl cationic compounds that exhibit broad spectrum antibiotic and antifungal activity, pharmaceutical compositions containing the compounds, and methods of treating bacterial and fungal infections using the compounds. The compounds were initially i... | 10/03/2006 |
| 7091220 | Substituted indole Mannich bases The present invention relates to substituted indole Mannich bases, processes of preparing substituted indole Mannich base, a medicament containing the same, and a pharmaceutical composition containing the same. ... | 08/15/2006 |
| 7001905 | Substituted diarylamines as MEK inhibitors Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are us... | 02/21/2006 |
| 6891065 | Advanced route for the synthesis of cPLA2 inhibitors A process for making a compound of formula (I) in which process the compound HC≡C—(CH2)n—NH2 is reacted with the compound R1—SO2Cl to produce an intermedia... | 05/10/2005 |
| 6787550 | Indole derivatives and their use for the treatment of osteoporosis amongst other applications A compound of formula (1) or a salt thereof, or a solvate thereof, wherein; R1 and R2 each independently represents C1-6alkoxy or halo; R3 and R4 | 09/07/2004 |
| 6743810 | Indol-3-yl derivatives Indol-3-yl derivatives of the general formula I in which A, B, X, R1, R2, R3, R4, R5, n and m are as defined in patent claim 1, and their physiologically acce... | 06/01/2004 |
| 6552065 | Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.... | 04/22/2003 |
| 6486153 | Phenylindole derivatives as 5-HT2A receptor ligands A class of tryptamine analogues bearing an optionally substituted phenyl nucleus at the 2-position are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prev... | 11/26/2002 |
| 6458824 | Solid preparation The present invention provides a solid preparation comprising a crystal of [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-y loxy]acetic acid (Compound A), especially a crystal of Compound A having a particle size of not larger tha... | 10/01/2002 |
| 6403577 | Hexamethyleneiminyl tachykinin receptor antagonists This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiolog... | 06/11/2002 |
| 6358994 | 2-acylaminopropanamines as tachykinin receptor antagonists This invention provides compounds of the Formula I: ##STR1## which are useful as tachykinin receptor antagonists. This invention also provides methods employing these compounds, as well as pharmaceutical formulations comprising these compounds.... | 03/19/2002 |
| 6358943 | N-substituted indolines as estrogenic agents This invention provides compounds of the formula ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, X, n and Y, are as defined in the specification, or a pharmaceutically acceptable sa... | 03/19/2002 |
| 6355805 | 댣-adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댣 adrenergic receptor agonists and are therefore useful in the treatment and prevention of metabolic disorders such as obesity, diabetes, and the like.... | 03/12/2002 |
| 6300364 | Medicinal compositions with cholesterol-lowering effect Pharmaceutical compositions having a cholesterol-lowering effect which comprises as the active ingredient a compound having a PPAR (peroxisome proliferator-activated receptor)δ activating effect or a PPARδ- and PPARγ-activating effect or a pharmaceutic... | 10/09/2001 |
| 6211224 | Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men an... | 04/03/2001 |
| 6090839 | Antidiabetic agents The instant invention is concerned with aryl and heteroaryl oxyacetic acid type compounds which are useful antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and related diseases and for lowering tri... | 07/18/2000 |
| 5965745 | Indole carbamates as leukotriene antagonists Compounds of the formula ##STR1## wherein R1 AND R2 are as defined, useful in the treatment of asthma, rheumatoid arthritis, osteoarthritis, bronchitis, chronic obstructive airways diseases, psoriasis, allergic rhinitis, atopic ... | 10/12/1999 |
| 5932743 | Methods for the solid phase synthesis of substituted indole compounds The present invention relates to novel substituted indole compounds of formula (I) ##STR1## having pharmacological activity, to processes for their preparation, to solid phase methods for preparing libraries of the compounds, to utilizing librar... | 08/03/1999 |
| 5919947 | Traceless solid phase synthesis of indole derivatives The present invention relates to a traceless solid phase process for the preparation of an indole derivative, which comprises the following steps: (1) reaction of an optionally substituted 2-iodoaniline derivative via the nitrogen atom of the NH2 mo... | 07/06/1999 |
| 5854277 | Thiophenebutanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T... | 12/29/1998 |
| 5852049 | Aromatic ethers derived from indoles which are useful as medicaments The present invention relates to new aromatic ethers derived from indole and having general formula (I) as well as to their preparation methods, pharmaceutical compositions containing them and their utilization as a medicament for the treatment of disease... | 12/22/1998 |
| 5817689 | Indole derivatives having a 2-phenyl-ethanolamino-substituted lower alkyl group at the 2-or 3-position thereof An indole derivative of the formula: ##STR1## wherein R1 is lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, lower alkoxycarbonyl, phenyl-lower alkoxy, lower alkyl being optionally substituted by hydroxy, di-lower ... | 10/06/1998 |
| 5804595 | Kappa opioid receptor agonists The invention provides certain amino acid conjugates of substituted 2-phenyl-N-1-(phenyl)-2-(1-heterocycloalkyl- or heterocycloaryl-)ethyl!acetamides useful for selectively agonizing kappa opioid receptors in mammalian tissue.... | 09/08/1998 |
| 5674889 | Aromatic compounds, compositions containing them and their use in therapy The present invention relates to compounds of formula (I) and salts and prodrugs thereof, wherein Q1 represents a phenyl group substituted by one or more halo optionally substituted naphthyl, optionally substituted indolyl, optionally substitut... | 10/07/1997 |
| 5607962 | Substituted indole derivatives Substituted indole derivatives are prepared by reacting appropriate carboxylic acids, if appropriate in the presence of auxiliaries, with appropriate amines. The substituted indole derivatives are suitable as active compounds in medicaments, in particular... | 03/04/1997 |
| 5594012 | Amino acid derivatives and anti-active oxygen agents A novel anti-active oxygen agent which comprises as active ingredient an amino acid derivative represented by the following general formula (I): ##STR1## wherein Ar represents a 2-hydroxyphenyl, 2-hydroxy-1-naphthyl or pyridyl group, and one or more ... | 01/14/1997 |
| 5532237 | Indole derivatives with affinity for the cannabinoid receptor Disclosed are indole derivatives having activity on the cannabinoid receptors and the methods of their preparation. The compounds are useful for lowering ocular intra ocular pressure and treating glaucoma because of the activity on the cannabinoid recepto... | 07/02/1996 |
| 5508432 | Modulators of cholecystokinin CCK modulators, e.g. agonists or antagonists, of the following formula (I): ##STR1## or a base-addtion salt thereof.... | 04/16/1996 |
| 5502061 | Peptidyl substituted benzamides and naphthamies The present invention provides HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.... | 03/26/1996 |
