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| Number | Title | Issue Date |
| 7375219 | Substituted indole compounds having NOS inhibitory activity The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other p... | 05/20/2008 |
| 7365090 | Substituted phenylindoles for the treatment of HIV This invention is in the area of phenylindoles that are useful for the treatment of HIV infection, and, in particular, phenylindoles that exhibit significant activity against resistant strains of HIV. The phenylindoles have at least two substituents other than hydro... | 04/29/2008 |
| 7365091 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful fo... | 04/29/2008 |
| 7259250 | C-nitroso compounds and use thereof A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less th... | 08/21/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7202383 | Compounds useful for modulating abnormal cell proliferation There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1... | 04/10/2007 |
| 7202268 | Derivatives of indole-3-carboxamide, preparation method thereof and application of same in therapeutics The invention relates to derivatives of indole-3-carboxamide having general formula (I): wherein: R1 represents a C3–C10 alkyl, a C5–C10 carbocyclic radi... | 04/10/2007 |
| 7176322 | Calcium receptor modulating agents The compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and the... | 02/13/2007 |
| 7157488 | N-(2-Arylethyl) benzylamines as antagonists of the 5-HTreceptor The present invention provides compounds of formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT6 receptor. The present invent... | 01/02/2007 |
| 7138418 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states... | 11/21/2006 |
| 7126009 | Palladium catalyzed indolization of 2-bromo or chloroanilines The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I) (I) | 10/24/2006 |
| 7122571 | Substituted hydrazones as inhibitors of cyclooxygenase-2 Compounds useful as inhibitors of cyclooxygenase-2 activity have the formulae I or Ia: wherein: Q1, Q2, n, m, X, Y and R are as defined herein. | 10/17/2006 |
| 7098307 | Neo-tryptophan The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptid... | 08/29/2006 |
| 7075582 | Methods for identifying and using MarR family polypeptide binding compounds Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides. ... | 07/11/2006 |
| 7071180 | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2â€... | 07/04/2006 |
| 7049308 | C-nitroso compounds and use thereof A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less th... | 05/23/2006 |
| 7041697 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorde... | 05/09/2006 |
| 7026515 | Optically active amine derivatives and preparation process therefor A readily available and inexpensive natural α-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to give an optically active 5-hydroxyoxazolidine represented by formula... | 04/11/2006 |
| 6951881 | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor. ... | 10/04/2005 |
| 6949556 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents The present invention relates to compounds of general formula (I), wherein R1-R4 have the meanings given in the specification, A is CH2, CHOH or CH—(C1-C3-alkyl), B and C a... | 09/27/2005 |
| 6939889 | Quarternary ammonium compounds Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans. ... | 09/06/2005 |
| 6921805 | Neo-tryptophan The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptid... | 07/26/2005 |
| 6919354 | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor ... | 07/19/2005 |
| 6867200 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents ... | 03/15/2005 |
| 6861444 | Bicyclic compounds Compounds of the general formula (I): or a salt thereof, wherein R1 is hydrogen, hydroxyl or halogen; R2 is NHSO2CH3, SO2NHCH3 or the like; R5 | 03/01/2005 |
| 6841563 | Aryloxy propanolamines for improving livestock production Disclosed is a compound represented by structural formula (I): R1 is a substituted or unsubstituted aryl group. R2 and R3 are independently —H, a C1-C4 straight chained or branched alkyl group. R4 and R5 are independently —H, a C1-C4 straight chained or branched... | 01/11/2005 |
| 6825352 | Preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs. ... | 11/30/2004 |
| 6803384 | Diaminopropionic acid derivatives A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusi... | 10/12/2004 |
| 6787535 | Indole derivatives with 5HT6 receptor affinity This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R5, R6 or R7 is a group of general Formula B, where... | 09/07/2004 |
| 6765099 | Neo-tryptophan The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptid... | 07/20/2004 |
| 6750242 | Positive modulators of nicotinic receptor agonists Compounds of Formula I wherein R1, R2, R3 and R4 are as defined in the specification, enantiomers thereof, pharmaceutically acceptable salts thereof, processes for preparing th... | 06/15/2004 |
| 6716837 | Heterocyclic compounds for the treatment of migraine Described herein are compounds useful in the treatment of migraine, which have the general formula: wherein: W is a CH group or a N atom; Z is N or C—R4; B and D are selected independently from CH and N, with th... | 04/06/2004 |
| 6710069 | 1-aryl- or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 03/23/2004 |
| 6710185 | Process for the preparation of cell proliferation inhibitors The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors. ... | 03/23/2004 |
| 6706751 | Dihydroindole and tetrahydroquinoline derivatives The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are asso... | 03/16/2004 |
| 6683101 | Bicyclic cyclohexylamines and their use as NMDA receptor antagonists Described are heterocycle-substituted cyclohexylamines of formula (I), and their pharmaceutically acceptable salts thereof. The compounds of the formula (I) are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders... | 01/27/2004 |
| 6583144 | Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein ... | 06/24/2003 |
| 6534535 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) below: ##STR1## are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 03/18/2003 |
| 6509357 | 1-aryl or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ##STR1##... | 01/21/2003 |
| 6503907 | Indole and dihydroindole derivatives The present invention relates to indole derivatives, dihydroindole derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are ass... | 01/07/2003 |
