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| Number | Title | Issue Date |
| 8124789 | Method for producing glycosylated indole compound and antibody against the compound This invention provides a method of producing a large amount of an α-form or β-form of N-pyranosyl-tryptophan having a specified structure and preparing an antibody therefrom. The method comprises a step of allowing a pyranose compound to react with a 3-pyrazyl-in... | 02/28/2012 |
| 7329354 | Purification of organic solvent fluids A chemical distribution system having improved organic solvent fluid purity and consistency includes a vessel containing ion-exchange media positioned within a fluid flow pathway such that the organic solvent fluid passes through the ion-exchange media, thereby effe... | 02/12/2008 |
| 7297800 | Process of producing glutamate derivatives The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzy... | 11/20/2007 |
| 7279582 | Retroviral protease inhibiting compounds A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed. ... | 10/09/2007 |
| 7146909 | Image forming material An image forming material, a lithographic printing plate precursor and a lithographic printing method, in which a color image with good visibility is obtained by laser exposure, are provided, wherein the image forming material and the lithographic printing plate pre... | 12/12/2006 |
| 7147878 | Modified soy products and methods for reducing odor and improving flavor of soy products A method for reducing odor in soy products and compositions containing soy products by adding or admixing a compound having one or more disulfide bonds to the soy product or composition. The disulfide compound includes a peptide containing at least cystine residue, ... | 12/12/2006 |
| 7030248 | Isolation of natural L-β-3-indolylalanine and enrichment of natural aliphatic amino acid mixtures with natural L-β-3-indolylalanine Processes for extracting amino acids from mixtures of amino acids, and compositions and mixtures formed therefrom. Applications include isolating natural L-β-3-indolylalanine (L-β-3) and providing natural or other amino acid mixtures enriched with the extracted L-... | 04/18/2006 |
| 6541644 | Isolation of natural L-ଲ-3-indolylalanine and enrichment of natural aliphatic amino acid mixtures with natural L-ଲ-3-indolylalanine Processes for isolating substantially pure natural L-ଲ-3-indolylalanine (L-ଲ-3) from a mixture of amino acids, such as a protein hydrolysate. A protein hydrolysate, for example of casein or soy protein, is passed over a polymeric resin attract... | 04/01/2003 |
| 6359061 | Amide compound libraries Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds. ... | 03/19/2002 |
| 6284897 | Method for crystallizing tryptophan A method for the crystallization of tryptophan, comprising storing a tryptophan solution at a pH of 8 to 13 and at a temperature of room temperature to 100° C. for 0.5 hour to 1 week and then, followed by crystallization.... | 09/04/2001 |
| 6207686 | Endothelin antagonists A compound of formula (I), in which: R1 is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2 is hydrogen, hydroxy or protected... | 03/27/2001 |
| 5945542 | Isolation of natural L-ଲ-3-indolylalanine and enrichment of natural aliphatic amino acid mixtures with natural L-ଲ-3-indolylalanine A process for isolating substantially pure natural L-ଲ-3-indolylalanine (L-ଲ-3) from a mixture of amino acids, such as a protein hydrolysate, is described. A protein hydrolysate, for example of casein or soy protein, is passed over a polymeric... | 08/31/1999 |
| 5892112 | Process for preparing synthetic matrix metalloprotease inhibitors Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, keratoconus, resteno... | 04/06/1999 |
| 5886191 | Amidinoindoles, amidinoazoles, and analogs thereof The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula I: ##STR1## wherein W, W1, W2, and W3 are selected from CH and N, provided that one of W1 and W2 is... | 03/23/1999 |
| 5773617 | Deallylation reagent and deallylation method using said reagent The present invention relates to a reagent and to a process which are useful, when carrying out an organic synthesis, for cleaving an allylic group from a function which is protected with the latter. This reagent is defined in that it contains: a) a solvent sy... | 06/30/1998 |
| 5756761 | Process for drying hydrophobic amino acids with improved process for increased bulk density A process for improving the solubility of hydrophobic amino acids in which hot saturated aqueous solutions of at least two different amino acids are first combined. A first step includes making a hot saturated aqueous solution of a first and hydrophobic a... | 05/26/1998 |
| 5750767 | Synthesis and use of amino acid fluorides as peptide coupling reagents The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting ... | 05/12/1998 |
| 5712418 | Synthesis and use of amino acid fluorides as peptide coupling reagents The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting ... | 01/27/1998 |
| 5703106 | Antagonists of endothelin receptors The present invention provides novel compounds having pharmacological properties represented by the general formula I ##STR1## processes for the manufacture, pharmaceutical compositions and the use of the compounds of formula I and salts thereof.... | 12/30/1997 |
| 5679852 | Process for the production of DTPA-monoamides of the central carboxylic acid and their use as pharmaceutical agents A process for the production of of general formula I diethylenetriaminepentacarboxylic acid monoamide derivatives ##STR1## in which E1, E2 and Z have varying meanings.... | 10/21/1997 |
| 5635379 | D-2-alkyl-tryptophan and peptides containing same Peptides containing in its amino acid chain a D-2-alkylTryptophan residue wherein the alkyl group has between one and three carbon atoms and having pharmacological activity similar to that of analogous peptides containing natural unsubstituted D-Tryptopha... | 06/03/1997 |
| 5622983 | N-substituted cycloalkyl and polycycloalkyl -substituted Trp-Phe- and phenethylamine derivatives Novel unnatural dipeptoids of -substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal tumors, or as antipsychotics are disclosed. Further the com... | 04/22/1997 |
| 5608078 | Phosphonomethyldipeptides and process for preparation thereof Dipeptide compounds and analogs thereof having a phosphonomethyl moiety are disclosed. These compounds inhibit Endothelin Converting Enzyme and are thus useful in treating conditions responsive to inhibition of production of Endothelin.... | 03/04/1997 |
| 5506362 | Process for the preparation of an -amino acid amide An -amino acid amide is prepared by reaction of an N -aryloxycarbonylamino acid with a compound containing a free amino group. This process makes it possible readily to prepare peptides, by direct reaction between the carboxyl gro... | 04/09/1996 |
| 5329014 | Method for recovering optically active tryptophan Optically active tryptophan of high purity can be obtained in high yields from a tryptophan fermentation broth, using crystallization of optically active tryptophan hydrochloride in combination with concurrent neutralization crystallization. According to ... | 07/12/1994 |
| 5300653 | Separation method of amino acids A method is provided for the separation of at least one aromatic amino acid from an aqueous solution of mixed amino acids including the aromatic amino acid. The aqueous solution is brought into contact with a strongly acidic gel-type cation exchange resin... | 04/05/1994 |
| 5283343 | 2-aryl substituted N-acetyltryptamines and process of preparing such This invention relates to novel melatonin derivatives, such as 2-aryl substituted N-acetyltryptamines, having pharmacological activity, e.g., melatonin antagonist activity, and methods for the synthesis thereof.... | 02/01/1994 |
| 5210215 | Tryptophane and 3-indolepyruvic acid, methods of production therefor 3-indolepyruvic acid derivatives substituted on the benzene moiety show good antagonizing activity on excitatory aminoacids and on free radicals, for which reason they are therapeutic agents in cerebral and peripheral degenerative pathologies. Their metho... | 05/11/1993 |
| 5101036 | Process for the preparation of N-hydroxy-alpha-amino acid amides The invention relates to a process for the preparation of N-hydroxy-alpha-amino acids and the derivatives thereof by reacting a derivative of an alpha-amino acid with an aromatic aldehyde to form a Schiff base, oxidizing the Schiff base to an oxaziridine ... | 03/31/1992 |
| 5085991 | Process of preparing purified aqueous indole solution A process for preparing substantially purified aqueous indole solution. In the process of the present invention, crude indole containing an organic impurity is dissolved in an organic solvent which is immiscible with water, the distribution ratio of the i... | 02/04/1992 |
| 5070208 | Method for crystallization of optically active tryptophan Optically active tryptophan is crystallized by a modification of a method of crystrallization of optically active tryptophan through neutralization by mixing an acidic or alkaline aqueous solution of optically active tryptophan, which is obtained by the r... | 12/03/1991 |
| 5057615 | Process for purifying tryptophan A process for purifying tryptophan is disclosed. In the process of the present invention, tryptophan is recrystallized in water-containing acetic acid. By the process of the present invention, tryptophan with high purity may be obtained with high yield wi... | 10/15/1991 |
| 4980096 | Photolabile blocked surfactants Surfactants which are blocked against surfactant action (identified herein as "photolabile blocked surfactants") by a photolabile protective or masking group but which, on exposure to actinic radiation, become unblocked are provided. Coating compositions ... | 12/25/1990 |
| 4978759 | Process for the stereospecific synthesis of optically pure 4-amino-3-hydroxycarboxylic acid derivatives The process described makes it possible to obtain optically pure 4-amino-3-hydroxycarboxylic acids by means of a series of stereoselective steps. The starting material is an alpha-amino acid in the L or D configuration, with which Meldrum's acid is reacte... | 12/18/1990 |
| 4912228 | Process of extraction of amino acids from aqueous solutions thereof An improvement in the process of extraction of amino acids from aqueous solutions in which the amino acids are extracted with quaternary ammonium extractants. A pretreatment of the amino acid containing aqueous solution with a tertiary amine prior to extr... | 03/27/1990 |
| 4886889 | Process for recovery of an amino acid from aqueous mixtures thereof Disclosed is a process for recovery of amino acids from aqueous mixtures. In particular, it relates to a treatment of said amino acid containing aqueous mixture prior to extraction of the amino acid with a water immiscible organic solution containing a wa... | 12/12/1989 |
| 4886888 | Extraction of amino an acid from aqueous mixtures thereof Amino acids can be purpified and/or concentrated by extracting aqueous mixtures such as fermentation broths by contacting an aqueous mixture containing amino acids with an organic solution containing a water insoluble extractant selected from the group co... | 12/12/1989 |
| 4837371 | Process for concentration of an aqueous solution of amino acid An aqueous solution containing amino acids of which the solubility in water at isoelectric point is low, can be highly concentrated by means of semipermeable membranes in the presence of a water-soluble organic solvent while increasing the solubility by a... | 06/06/1989 |
| 4837332 | Process for blocking amino acids with the tertiary-alkoxycarbonyl group Amino acid salt having at least one unblocked amino group and comprising at least one cation which has a nitrogen cationic atom is reacted with 1-(tertiary-alkoxycarbonyl)imidazole in the liquid phase and in the presence of essentially inert organic solve... | 06/06/1989 |
| 4822890 | Method for the production of amino terminus protected naturally occurring amino acids A method for the production of substantially 100% pure N-urethane protected amino acids is disclosed. This method eliminates the formation of di-peptide and tri-peptide contaminants. Reaction of blocking reagents at the carboxylate site on a protec... | 04/18/1989 |
