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| Number | Title | Issue Date |
| 7989639 | Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide Salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide are prepared by various methods. ... | 08/02/2011 |
| 7897788 | Indol-1-yl-acetic acid derivatives The invention relates to indol-1-yl-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical co... | 03/01/2011 |
| 7678925 | Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. ... | 03/16/2010 |
| 7674915 | Process for manufacturing a glutamic acid derivative and a pyroglutamic acid derivative and a novel intermediate in the manufacture thereof Glutamic acid derivatives, in particular monatin, may be conveniently prepared by alkylating a 4-protected hydroxyl pyroglutamic acid derivative with an alkylating agent to prepare a 4-protected hydroxyl-4-alkylglutamic acid derivative, followed by the steps of hydr... | 03/09/2010 |
| 7612214 | Organic amine salts of glutamic acid derivatives and their application The present invention provides an organic amine salt of monatin, or crystal form thereof, and its application as well as a method for resolving the stereoisomers of monatin by forming its salt. The present invention further provides a salt form of monatin that is us... | 11/03/2009 |
| 7598399 | Methods for synthesis of 3-amino-1-arylpropyl indoles A method comprising: hydrogenating an indole propionamide compound of formula h with vitride, to form an aminopropyl indole compound of formula i | 10/06/2009 |
| 7563909 | Statin derivatives Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing chol... | 07/21/2009 |
| 7534898 | Process for producing monatin or salt thereof To provide a process for producing monatin where steric configuration of 2-position is in an R configuration or a salt thereof by isomerization of 2-position of monatin where steric configuration of 2-position is in an S configuration. A process for producing... | 05/19/2009 |
| 7396941 | Method for producing monatin By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organic solvent, and the crystalliz... | 07/08/2008 |
| 7390909 | Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. ... | 06/24/2008 |
| 7348353 | Acetylene derivatives having mGluR 5 antagonistic activity The invention provides compounds of formula (I) wherein m, n, A, R, R′, R″, R0, X and Y are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals in the treatment of e.g. nervous system disord... | 03/25/2008 |
| 7321045 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. Th... | 01/22/2008 |
| 7304079 | Substituted indolealkanoic acids Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as metho... | 12/04/2007 |
| 7297681 | Growth hormone secretagogues The invention relates to compounds of formula I which are useful for elevating the plasma level of growth hormone in a mammal as well as for the treatment of growth hormone secretion deficiency, growth retardation in child ... | 11/20/2007 |
| 7288553 | Indole derivatives as selective androgen receptor modulator (SARMS) The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... | 10/30/2007 |
| 7241802 | Substituted cyclohexylcarboxylic acid amide compounds Substituted cyclohexylcarboxylic acid amide compounds, processes for their production, pharmaceutical compositions containing these compounds and the use of substituted cyclohexylcarboxylic acid compounds for producing pharmaceutical compositions for treating condit... | 07/10/2007 |
| 7173013 | Treatment of tuberculosis using immunomodulator compounds Tuberculosis in an animal is treated by administration of a therapeutically effective amount of an immunomodulator of formula A. In formula (A), n is 1 or 2, R is hydrogen, acyl, alkyl or a peptide fragment, and X is an aromatic or heterocyclic amino acid or a deriv... | 02/06/2007 |
| 7166463 | Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments,... | 01/23/2007 |
| 7129264 | Biarylmethyl indolines and indoles as antithromboembolic agents The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or hydrate form thereof, wherein the variables A, B, L1, L2, X1, X | 10/31/2006 |
| 7091182 | Method for assisting in differential diagnosis and treatment of autistic syndromes A novel relationship between pancreatico-biliary secretion and autistic syndrome is disclosed. This relationship enables a novel therapy for the treatment of the symptoms of autistic syndromes, comprising the administration of a therapeutically effective, preferably... | 08/15/2006 |
| 7087637 | Substituted indoles which are PARP inhibitors The present invention relates to novel indole derivatives, to their preparation and to their use, as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30), for producing drugs. ... | 08/08/2006 |
| 7067551 | Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties. ... | 06/27/2006 |
| 7064219 | Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. ... | 06/20/2006 |
| 7026485 | Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 04/11/2006 |
| 7026339 | Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions contai... | 04/11/2006 |
| 6916841 | Inhibitors of phospholipase enzymes Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclos... | 07/12/2005 |
| 6881727 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof. ... | 04/19/2005 |
| 6878739 | Composition for treating or preventing glomerulopathy A composition for treating or preventing glomerulopathy which contains a compound of the formula (I): wherein, for example, R1 and R2 are each independently hydrogen atom, optionally ... | 04/12/2005 |
| 6858642 | Indole derivatives The invention relates to 1-(R1)-2-(R2)-3-(Y-X—NH-A- or Z-A-)-4,5,6,7-R)0.4-indoles, and their acid addition salts where the compounds are basic, wherein A is C1-4 alkylene, X is >CH2, >C═O or >C═S, and the... | 02/22/2005 |
| 6821986 | Amino acid derivatives and their use as medicines Novel compounds of formula wherein the substituents are defined as in the specification and are useful for inhibiting neuronal NO synthase or inducible NO synthase as well as inhibiting lipidic peroxidation. ... | 11/23/2004 |
| 6794407 | Methods for treating circadian rhythm phase disturbances A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined... | 09/21/2004 |
| 6753327 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: ... | 06/22/2004 |
| 6638963 | Methods for treating circadian rhythm disorders A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production so that the durations of the effective plasma concentrations... | 10/28/2003 |
| 6596752 | Inhibitors of 댔댡 mediated cell adhesion The present invention relates to small molecules according to the formula [I]: ##STR1## which are potent inhibitors of 댔ଲ.sub.1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing | 07/22/2003 |
| 6583169 | N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein; A is N or CH; R1 and R2 represents hydrogen or lower alkyl; G, R3, R4, R5, R6, R | 06/24/2003 |
| 6569636 | Assay for modulators of metallo-enzyme activity An assay is disclosed for determining whether a test compound modulates the activity of an enzyme having a metallated active site. The assay method employs a comparison of the binding ability of the metallated and unmetallated forms of the enzyme to the t... | 05/27/2003 |
| 6559334 | Polymers chromatographic separation of enantiomers The invention relates to novel optically active polymerizable dipeptides, to the process for the preparation thereof, to the polymerization thereof and to the use of the polymers as adsorbents for the chromatographic separation of enantiomers.... | 05/06/2003 |
| 6515124 | Dehydroamino acids Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasi... | 02/04/2003 |
| 6506759 | Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 01/14/2003 |
| 6495693 | N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 12/17/2002 |
