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| Number | Title | Issue Date |
| 7858811 | Process for the preparation of indoles A process for the preparation of indoles, e.g. 1,2,3,9-tetrahydro-carbazol-4-one and derivatives thereof. ... | 12/28/2010 |
| 7598398 | Acyl indoles, compositions containing such compounds and methods of use The present invention relates to substituted indoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus and r... | 10/06/2009 |
| 7566791 | Substituted 3-carbonyl--indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided: wherein: R1, R2, R3, R4 and R5 are as defined herein wh... | 07/28/2009 |
| 7368471 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides compounds of the formula: wherein: X is a chemical bond, —CH2— or —C(O)—; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, ... | 05/06/2008 |
| 7351730 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,... | 04/01/2008 |
| 7351726 | Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ... | 04/01/2008 |
| 7348351 | Substituted 3-alkyl and 3-arylalkyl -indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) The invention formula substituted 3-alkyl and 3-arylalkyl 1H indol-1yl acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure ... | 03/25/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7332521 | Substituted indoles The present invention relates generally to substituted indoles such as substituted 1H-indole-2-carboxylic acid derivatives, and methods of using them. ... | 02/19/2008 |
| 7323575 | Process for the synthesis of (2S)-indoline-2-carboxylic acid Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts. ... | 01/29/2008 |
| 7268159 | Substituted indoles The present invention relates generally to substituted indoles and methods of using them. ... | 09/11/2007 |
| 7265148 | Substituted pyrrole-indoles The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them. ... | 09/04/2007 |
| 7259182 | Aryl, aryloxy, and aklyloxy substituted 1-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula I are provided: wherein: R1, R2, and R3, are as defined herein, as well as pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor ... | 08/21/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7202268 | Derivatives of indole-3-carboxamide, preparation method thereof and application of same in therapeutics The invention relates to derivatives of indole-3-carboxamide having general formula (I): wherein: R1 represents a C3–C10 alkyl, a C5–C10 carbocyclic radi... | 04/10/2007 |
| 7196204 | Method for the synthesis of s-indoline-2-carboxylic acid and application thereof in the synthesis of perindopril Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts. ... | 03/27/2007 |
| 7186749 | Pyrrolo-naphthyl acids and methods for using them The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 03/06/2007 |
| 7163954 | Substituted naphthyl benzothiophene acids The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them. ... | 01/16/2007 |
| 7160918 | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor (PAI-1) This invention provides indole oxo-acetyl amino acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure: | 01/09/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7141592 | Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ... | 11/28/2006 |
| 7101903 | Substituted dihydropyrano indole-3,4-dione derivatives as inhibitiors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula (I) and II) are provided wherein: X is an alkali metal or a basic amine moiety; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, pheny... | 09/05/2006 |
| 7078429 | Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided: wherein: R1, R2, R3, R4 and R5 are as defined herein which are useful a... | 07/18/2006 |
| 7074817 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides compounds of the formula: wherein: X is a chemical bond, —CH2— or —C(O)—; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridi... | 07/11/2006 |
| 7056943 | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides indole oxo-acetyl amino acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure: | 06/06/2006 |
| 7030239 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases. ... | 04/18/2006 |
| 6914145 | Acylation process The present invention is concerned with the acylation of indoles, specifically the preparation of 3-acylated indoles which may be further treated to provide indoles having an alternative substituent at the 3-position. ... | 07/05/2005 |
| 6902721 | Inhibitors of proteasomal activity for stimulating bone growth The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyro... | 06/07/2005 |
| 6903104 | Indol-3-YL-2-oxoacetamide compounds and methods of use thereof The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula. In this formul... | 06/07/2005 |
| 6841685 | Methods for making bis-heterocyclic alkaloids Methods for making bis-heterocyclic compounds, especially bis-heterocyclic compounds having five and six-membered heterocyclic linkers are described. Also described are methods for making an alpha amino ketone synthon that enables facile syntheses of bisindole compo... | 01/11/2005 |
| 6831095 | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 12/14/2004 |
| 6781000 | Alpha-ketoamide inhibitors of 20S proteasome α-ketoamide compounds useful for treating disorders mediated by 20S proteasome in mammals having the following formula: wherein X2 is Ar or Ar—X3 wherein X3 is is —C═O, or —CH | 08/24/2004 |
| 6635670 | sPLA2 inhibitors A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.... | 10/21/2003 |
| 6613794 | Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation The invention relates to new hydroxyindoles of the Formula, ##STR1## their use as inhibitors of phosphodiesterase 4 and processes for their preparation.... | 09/02/2003 |
| 6608084 | Aza-bicycles which modulate the inhibition of cell adhesion ##STR1## The invention is directed to physiologically active compounds of formula (I) wherein R1 represents R3 --Z3 --, R3 --L2 --R4 --Z3 --, R3 --L3 --Ar1 | 08/19/2003 |
| 6608099 | Indole sPLA2 inhibitors A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases.... | 08/19/2003 |
| 6569888 | Anti-inflammatory indole derivatives Compounds of formula (I) or a pharmaceutically acceptable salt, in vivo hydrolysable ester, or an N--C1-6 alkyl or N,N-di-(C1-6 alkyl)amide thereof, where X is CH2 or SO2 ; R1 is an aryl optionally su... | 05/27/2003 |
| 6506787 | Indole derivatives having an antiviral activity A compound of the formula: ##STR1## wherein R1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like, R2 is hydrogen, lower alkyl, or optionally substituted aralkyl, or the like, R3, R4, ... | 01/14/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6441192 | Acylation process The present invention is concerned with the acylation of indoles, specifically the preparation of 3-acylated indoles which may be further treated to provide indoles having an alternative substituent at the 3-position.... | 08/27/2002 |
