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| Number | Title | Issue Date |
| 7358272 | Methods of using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4 acetylaminoisoindoline 1,3-dione Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also d... | 04/15/2008 |
| 7276529 | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione Methods of treating, managing or preventing exercise-induced asthma are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione alone or in combination with a second ac... | 10/02/2007 |
| 7208516 | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione Methods of treating, managing or preventing psoriatic arthritis are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione alone or in combination with a second active... | 04/24/2007 |
| 7173059 | Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed. ... | 02/06/2007 |
| 7173058 | Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel compounds, pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof, pharmaceutical compositions of these compounds, and methods of using these comp... | 02/06/2007 |
| 6962940 | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also d... | 11/08/2005 |
| 6660736 | Phthalimido derivatives and a process for their preparation This invention relates to phthalimido derivatives of the formula ##STR1## wherein X is --N.dbd. or --CH.dbd., and R1 to R4 and m are as defined in the specification, as well as their pharmaceutically acceptable salts. The invention f... | 12/09/2003 |
| 6410749 | Process for the preparation of optically active amino alcohols Process for preparing optically active ଲ-amino alcohols represented by a general formula (2): Ra--C*H(OH)--C*H(Rb)--Rc wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, Rb is one memb... | 06/25/2002 |
| 6352958 | Cycloimido-substituted benzofused heterocyclic herbicides Novel herbicidal compounds, compositions containing them, and methods for their use in controlling weeds are disclosed. The novel herbicidal compounds are represented by formula I: ##STR1## where J is a 1-substituted-6-trifluoromethyl-2,4-pyrimidinedione-... | 03/05/2002 |
| 6326369 | Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi... | 12/04/2001 |
| 6020358 | Substituted phenethylsulfones and method of reducing TNF levels Phenethylsulfones substituted in the position to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNF in a mammal. Typical embodiments are 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-a... | 02/01/2000 |
| 6008268 | Photoreactor composition, method of generating a reactive species, and applications therefor A method of generating reactive species which includes exposing a photoreactor composition to radiation, in which the photoreactor composition comprises a wavelength-specific sensitizer associated with one or more reactive species-generating photoinitiato... | 12/28/1999 |
| 5929217 | Reactive dyes with a benzo-fused heterocycle as anchor Reactive dyes of the formula I ##STR1## where a is 1 or 2, b is 0 or 1, Z1 is hydrogen, C1 -C6 -alkyl, C1 -C6 -alkoxy, halogen, nitro, amino, hydroxysulfonyl, C1 -C6 -alkoxycarbo... | 07/27/1999 |
| 5927283 | Allosteric modifiers of hemoglobin A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgic... | 07/27/1999 |
| 5925759 | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive int... | 07/20/1999 |
| 5919948 | Asymmetric ligands useful for transition metal catalyzed bond forming reactions and epoxide reactions therewith A novel ligand having the Formula 1 structure has proved remarkably successful in the amination of butadiene monoepoxide, which is a potentially desirable substrate for an asymmetric synthesis providing access to each enantiomer of vinylglycinol. ##S... | 07/06/1999 |
| 5886110 | Binary-branched polyoxaalkylene macromolecules process for making them and their uses Branched, dendrimeric macromolecules having a central nucleus and a series of polyoxaalkylene chains that radiate from the nucleus and spread into the surrounding space branching a cascade fashion until the desired size results. Molecules formed in this m... | 03/23/1999 |
| 5861427 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is... | 01/19/1999 |
| 5854277 | Thiophenebutanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T... | 12/29/1998 |
| 5789434 | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each... | 08/04/1998 |
| 5780644 | Branced polyoxaalkyl macromolecules Branched, dendrimeric-type macromolecules composed essentially of a central nucleus and of a series of polyoxaalkyl chains that depart from said nucleus and spread into the surrounding space branching in a cascade fashion useful as carriers of drugs, cont... | 07/14/1998 |
| 5705521 | Use of allosteric hemoglobin modifiers in combination with radiation therapy to treat carcinogenic tumors A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in radiation oncology applications. The compounds are capable of acting on hemoglobin in whole blood... | 01/06/1998 |
| 5693797 | Process for preparing brominated phthalimides A process for the preparation of brominated phthalimides that involves mixing tetrabromophthalic anhydride, an organic acid, and an organic dispersing agent in water at approximately 110° C. under 1 bar pressure is disclosed. An amine is added and the re... | 12/02/1997 |
| 5677330 | Medical uses of allosteric hemoglobin modifier compounds in patient care A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgic... | 10/14/1997 |
| 5665877 | Synthesis of bisindolylmaleimides The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because i... | 09/09/1997 |
| 5648375 | Use of hydrophobic compounds and anesthetics in combination with allosteric hemoglobin modifiers Allosteric hemoglobin modifier compound activity on p50 is potentiated by using the compound in combination with a hydrophobic compound such as an anesthetic.... | 07/15/1997 |
| 5637702 | Sulfur compounds Sulfur compounds of the formula ##STR1## where n is 0 or 2, R1 and R2 are hydrogen, C1 -C6 -alkyl, C1 -C6 -alkoxy, halogen, nitro, amino, hydroxysulfonyl, C1 -C6 ... | 06/10/1997 |
| 5614647 | Intermediates for the synthesis of bisindolylmaleimides The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because i... | 03/25/1997 |
| 5576445 | Intermediates for reactive dyes Compounds of the formula ##STR1## in which the variables are as defined in the claims and which are suitable diazo components for the synthesis of fibre-reactive dyes are described.... | 11/19/1996 |
| 5541347 | Synthesis of bisindolylmaleimides The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because i... | 07/30/1996 |
| 5491232 | Sulfur compounds useful for preparation of dyes Sulfur compounds of the formula ##STR1## where n is 0 or 2, R1 and R2 are hydrogen, C1 -C6 -alkyl, C1 -C6 -alkoxy, halogen, nitro, amino, hydroxysulfonyl, C1 -C6 ... | 02/13/1996 |
| 5451596 | Cycloalkyl amine bis-aryl squalene synthase inhibitors This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol... | 09/19/1995 |
| 5440048 | 1-piperazinyl-2-butenes and -2-butynes Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.... | 08/08/1995 |
| 5432191 | Allosteric hemoglobin modifiers to decrease oxygen affinity in blood A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood dur... | 07/11/1995 |
| 5401426 | Lactobionic acid amide compositions and their use Lactobionic acid amide compositions synthesized from lactobionic acid and a mixture of primary fatty amines, which contains at least 30 percent by weight of fatty amines having a chain length of 14 to 18 carbon atoms, and their use as softening, detergent... | 03/28/1995 |
| 5356860 | Styrene derivatives useful as herbicides and defoliants Abstract of the Disclosure: Styrene derivatives I ##STR1## where R1 is H or halogen, R2 is halogen, R3 is H, halogen or C1 -C4 -alkyl, R4 is CN or C1 -C6 -alkylca... | 10/18/1994 |
| 5330884 | Photographic element with near-infrared antihalation layer Disclosed is a photographic element comprising an antihalation dye of formula: ##STR1## wherein X1, X2 independently represents --CR8 R9 --, --S--, --Se--, --NR10 --, --CH.dbd.CH-- or --O--; n is... | 07/19/1994 |
| 5290803 | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood dur... | 03/01/1994 |
| 5250701 | Allosteric hemoglobin modifiers which decrease oxygen affinity in blood A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood dur... | 10/05/1993 |
| 5107063 | Aqueous soluble infrared antihalation dyes Sulfoalkyl substituted indolenine dyes that absorb infrared radiation and photosensitive elements containing said dyes are disclosed. These dyes are useful as antihalation dyes in infrared sensitive photographic elements which show dye low stain. These dy... | 04/21/1992 |
