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| Number | Title | Issue Date |
| 7943785 | Process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2- phthalimidomethylcyclopropane The present invention provides a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcyclopropane with an orthoester and a brønsted acid, a... | 05/17/2011 |
| 7820831 | Compounds comprising a thiocarbonyl-sulfanyl group which can be used for the radical synthesis of α-perfluoroalkylamine compounds The invention relates to compounds having the general formula (I), the method of preparation thereof and the use thereof in organic radical synthesis. The invention also relates to compounds having the formula (II), the method of preparation thereof and a method for... | 10/26/2010 |
| 7405237 | Isoindoline compounds and methods of their use Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases and disorders mediated by PDE 4, using the compounds are also disclos... | 07/29/2008 |
| 7345062 | Substituted acylhydroxamic acids and method of reducing TNFαlevels Imido and amido substituted acylhydroxamidic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propandylamino)propanoate. ... | 03/18/2008 |
| 7262222 | Synergistic mixtures of o-phenylphenol and other nitrogen and aldehyde microbiocides Ortho phenylphenol or its sodium salt is shown to form synergistic antimicrobial mixtures with nitrogen and aldehyde-containing microbiocides. ... | 08/28/2007 |
| 7244759 | Isoindoline compounds and methods of making and using the same The invention encompasses isoindoline compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel... | 07/17/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7081464 | Topical compositions of cyclic amides as immunotherapeutic agents Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. ... | 07/25/2006 |
| 7056932 | Heterocyclyl substituted 1-alkoxy acetic acid amides The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as ... | 06/06/2006 |
| 6989401 | Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable s... | 01/24/2006 |
| 6939986 | Process for preparing 1,2-diamino compounds The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides. ... | 09/06/2005 |
| 6911464 | N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel N-alkyl-hydroxamic acid-isoindolyl compounds, pharmaceutical compositions of these compounds, and methods of using these compounds and compositions for treatment or prevention of various diseases and disorders, for example, diseases a... | 06/28/2005 |
| 6844359 | Substituted imides Novel imides are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is (R)-2-Phthalimido-3-(3′,4′-dimethoxyphenyl)propane. ... | 01/18/2005 |
| 6812237 | N-substituted peptidyl nitriles as cysteine cathepsin inhibitors Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in ... | 11/02/2004 |
| 6699899 | Substituted acylhydroxamic acids and method of reducing TNF levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate.... | 03/02/2004 |
| 6693202 | Muscarinic receptor antagonists Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscari... | 02/17/2004 |
| 6660736 | Phthalimido derivatives and a process for their preparation This invention relates to phthalimido derivatives of the formula ##STR1## wherein X is --N.dbd. or --CH.dbd., and R1 to R4 and m are as defined in the specification, as well as their pharmaceutically acceptable salts. The invention f... | 12/09/2003 |
| 6498004 | Silver halide light sensitive emulsion layer having enhanced photographic sensitivity This invention provides a photographic element comprising at least one silver halide emulsion layer in which the silver halide is sensitized with a compound of the formula (a): Ɗ-(t)m -XY' (a) XY'-(t)m -Ɗ (b) Ɗ-(t)m -XY'-(... | 12/24/2002 |
| 6436949 | Heterocyclically substituted benzamides and their use Heterocyclically substituted benzamides of the formula I ##STR1## are described, where R1, R2, R3, R4, R5, X, m and n have the meanings given in the description. The novel compounds are useful for con... | 08/20/2002 |
| 6429221 | Substituted imides Novel imides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-Phthalimido-3-(3',4'-dimethoxyphenyl)propane.... | 08/06/2002 |
| 6359061 | Amide compound libraries Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds. ... | 03/19/2002 |
| 6352958 | Cycloimido-substituted benzofused heterocyclic herbicides Novel herbicidal compounds, compositions containing them, and methods for their use in controlling weeds are disclosed. The novel herbicidal compounds are represented by formula I: ##STR1## where J is a 1-substituted-6-trifluoromethyl-2,4-pyrimidinedione-... | 03/05/2002 |
| 6342508 | N-hydroxy-2-(Alkyl,Aryl or Heteroaryl sulfanyl, sulfinyl or sulfonyl) 3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMps) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 01/29/2002 |
| 6310057 | -ketoamide multicatalytic protease inhibitors This invention relates to -ketoamide inhibitors of multicatalytic protease (MCP), to compositions including such inhibitors, and to methods for the use of MCP inhibitors. The MCP inhibitors of the present invention are useful, for example, to retar... | 10/30/2001 |
| 6306873 | Substituted ଲ-thiocarboxylic acids This invention relates to compounds of general formula (I): ##STR1## in which Ar is a group selected from: ##STR2## A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and Y represents carboxy or an acid bioisostere. These c... | 10/23/2001 |
| 6294573 | Reverse hydroxamate inhibitors of matrix metalloproteinases Compounds having the formula ##STR1## are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.... | 09/25/2001 |
| 6288063 | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)x A--B--D--E--G whe... | 09/11/2001 |
| 6277987 | Sulfonylamino acid and sulfonylamino hydroxamic acid derivatives Compounds of formula ##STR1## wherein W is --OH or --NHOH; X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH2)m moiety by a ring nitrogen, --CONR2 ... | 08/21/2001 |
| 6265432 | Flourine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A,... | 07/24/2001 |
| 6239288 | Biphenyl hydroxy imino butyric acids and their derivatives for treating arthritis Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) an... | 05/29/2001 |
| 6235922 | Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: Y1 and Y2 are each independently hydrogen, alkyl, aryl,... | 05/22/2001 |
| 6172057 | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 01/09/2001 |
| 6172085 | Cyclic ether compounds as sodium channel modulators A compound of the formula: ##STR1## wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lowe... | 01/09/2001 |
| 6169103 | Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A,... | 01/02/2001 |
| 6160126 | Synthetic Intermediates for the preparation of N, N'-Di-substituted isothiourea derivatives and N-cyclic(methyl)-N'-Substituted isothiourea derivatives Novel Intermediates ##STR1## wherein R is a substituted or unsubstituted hydrocarbon residue or acyl group; X is an electron withdrawing group; Y1 and Y2, which are the same or different, are each independently oxygen or sulfur;... | 12/12/2000 |
| 6150416 | Nanomolar, non-peptide inhibitors of cathepsin D The present invention provides non-peptide cathepsin D binding compounds and methods for using such compounds in the detection, labelling and inhibition of cathepsin D.... | 11/21/2000 |
| 6114372 | Peptidyl compounds having MMP and TNF inhibitory activity Compounds of formula (I) having MMP and TNF inhibitory activity. ##STR1##... | 09/05/2000 |
| 6090840 | Peptidyl compounds having MMP and TNF inhibitory activity The subject invention concerns mercaptoalkylacyl compounds of formula (I): ##STR1## The compounds of the subject invention can be used to inhibit matrix metalloproteinases and/or TNF- and L-selectin sheddase-mediated diseases including degener... | 07/18/2000 |
| 6066743 | Solventless preparation of phthalimides A method for the solventless synthesis of a phthalimide or phthalimide mixture is provided comprising contacting at least one amine reactant and at least one anhydride reactant in a solventless environment at a first temperature sufficient to allow the re... | 05/23/2000 |
| 6017889 | Metalloproteinase inhibitors Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a --CO2 H or --CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption. ##STR1##... | 01/25/2000 |
