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| Number | Title | Issue Date |
| 8030500 | Substituted isoindoles for the treatment and/or prevention of Aβ- related pathologies The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome, β-amyloid... | 10/04/2011 |
| 7585982 | Methods for producing isoindole derivatives The present invention relates to a method for producing an isoindole derivative (compound (II)) with the following general formula (II): (wherein R1 and R2 each independently represents a C1-6 | 09/08/2009 |
| 7375236 | Methods for producing cyclic benzamidine derivatives In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-subs... | 05/20/2008 |
| 7244730 | 2-iminopyrrolidine derivatives A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, et... | 07/17/2007 |
| 7038730 | Matched pulse shaping filter A communications receiver receives a signal which has not been filtered by a matched pulse shaping filter. In the receiver, a circuit element processes the received signal and as a part of that process introduces additional linear distortion into the processed recei... | 05/02/2006 |
| 7023489 | Method and device for detecting the parity of successive fields of an interlaced video signal Successive values of a horizontal phase of a video signal are determined a predetermined integer number of video lines after the successive occurrences of vertical synchronization pulses. The successive values of a parity bit are updated according to the successive ... | 04/04/2006 |
| 6660741 | Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor The present invention provides methods for the asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: ##STR1## where R1 is an optionally substituted or halogenated al... | 12/09/2003 |
| 6376530 | Cyclic amidines useful as NMDA NR2B antagonists The invention encompasses novel compounds of Formula I as well as a method of treating NMDA mediated diseases comprising administration to a patient in need of such treatment a non-toxic amount of a compound of Formula I effective to block the NMDA NR2B r... | 04/23/2002 |
| 6340691 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors Compounds of the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.... | 01/22/2002 |
| 6262302 | N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid pep... | 07/17/2001 |
| 6252077 | 1-(N'-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower alkoxy;... | 06/26/2001 |
| 6245768 | 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower alkoxy;... | 06/12/2001 |
| 6153652 | N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid pep... | 11/28/2000 |
| 6063924 | Soluble chromophores containing solubilising groups which can be easily removed Compounds of formula A(B)x (I), wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxa... | 05/16/2000 |
| 6060606 | Dipyrromethene metal chelate compounds An optical recording medium having at least a recording layer and a reflective layer on a substrates, the said recording layer contains a dipyrromethene metal chelate compound obtained from a dipyrromethene compound represented by the general formula (1) ... | 05/09/2000 |
| 6031097 | 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower al... | 02/29/2000 |
| 5994143 | Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformational... | 11/30/1999 |
| 5955618 | Circuit for generating field identification signal and method therefor A field identification signal generating circuit for a receiver for receiving a high-definition signal, and a method therefor. According to the method, a first correlation value is calculated, between the high-definition signal and a first reference signa... | 09/21/1999 |
| 5932729 | 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower al... | 08/03/1999 |
| 5716446 | Isoindoline pigments based on aminoquinoxalinediones Novel isoindoline pigments of the formula (I): ##STR1## in which R1 is --CN; R2 is --CN or a saturated or unsaturated, aromatic or non-aromatic, 5- to 7-membered heterocyclic ring system which can be modified by fusion or bridgi... | 02/10/1998 |
| 5602168 | 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower al... | 02/11/1997 |
| 5559247 | Carboxylate and heat-sensitive recording material using same A carboxylate is herein disclosed which is represented by the formula (1) or (2) ##STR1## wherein a ring X is an aromatic residue which may have a substituent; the other substitutents are as defined herein. A heat-sensitive recording material co... | 09/24/1996 |
| 5554633 | Substituted amines as tachykinin receptor antagonists Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H or C1-6 alkyl; R1 | 09/10/1996 |
| 5516789 | Lipoxygenase and cyclooxygenase inhibiting compounds Compounds having the structure ##STR1## or a pharmaceutically acceptable salt thereof have activity as inhibitors of cylooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B4, C4, D4, and E4 | 05/14/1996 |
| 5484901 | Isoindolineazo pigments Isoindolineazo pigments of the general formula I ##STR1## where A is the radical of an active-methylene compound or .dbd.S; L is substituted or unsubstituted 1,4-phenylene, 1,3-phenylene or 1,5-naphthylene; K is the radical of a coupling component K--H; a... | 01/16/1996 |
| 5387694 | Chromogenic methylenepyrrolines The present invention relates to chromogenic methylenepyrrolines and processes and intermediates for their preparation and to their use. The chromogenic methylenepyrroline compounds according to the invention have the formula (I) defined in claim 1. These colo... | 02/07/1995 |
| 5356860 | Styrene derivatives useful as herbicides and defoliants Abstract of the Disclosure: Styrene derivatives I ##STR1## where R1 is H or halogen, R2 is halogen, R3 is H, halogen or C1 -C4 -alkyl, R4 is CN or C1 -C6 -alkylca... | 10/18/1994 |
| 5162518 | Heterocyclic compounds and porphyrin compounds obtainable therefrom Porphyrins of the formula ##STR1## in which the substituents have the meaning given in the description are obtained by heating compounds of the formula ##STR2## if appropriate in the presence of compounds of the formula ##STR3## The po... | 11/10/1992 |
| 5091532 | Process for the preparation of pigments based on isoindole A new process for the preparation of pigments of the formula ##STR1## comprises first reacting phthalodinitrile in an organic medium in the presence of a base with an alcohol and then with a compound of the formula ##STR2## in the presence of wa... | 02/25/1992 |
| 4997740 | Electrophotographic toners with substituted 3-amino-1-imino-isoindolenine salts The invention relates to positively charged electrophotographic toners which, in addition to customary resin and pigment particles, contain an additive which intensifies the cationic charge, of the general formula ##STR1## wherein R1 and R... | 03/05/1991 |
| 4988711 | HMG-CoA reductare-inhibiting N-substituted N-amino-pyrroles Inhibiting HMG-CoA reductase, as in treating hyperlipopproteinaemia, lipoproteinaemia and arteriosclerosis, with the new N-substituted N-amino-pyrroles of the formula ##STR1## in which R1 is an organic radical, R2 is an aryl or ... | 01/29/1991 |
| 4879293 | Pyrrols [3,4-8]pyrazine derivatives, their production and use as anti-anxiety agents The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH2)l --S-- is an i... | 11/07/1989 |
| 4865650 | Novel compositions based on tetrachloroisoindolinone pigments Composition of matter containing: (a) a compound of the formula I ##STR1## in which A is one of the groups of the formulae ##STR2## in which B is --O--, --S--, --SO2 --, --N.dbd.N--, --CH2 --, --CH.dbd.CH--, --O--CH2... | 09/12/1989 |
| 4810717 | 2-hydroxypropylamine aryl ester derivatives Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR2 COR1, --NR | 03/07/1989 |
| 4786646 | Cyclopropylpropenamides The invention relates to compounds of the formula ##STR1## Y is O or S, *A is paraphenylene or *--(CH2)n --(X)m --(CH2)r --, X is O, S or --CH.dbd.CH--, n or r, independently, are integers from 0... | 11/22/1988 |
| 4785114 | Quinophthalone dyes Quinophthalone dyes of the formula ##STR1## where X is O or NC--C--R, where R is cyano, unsubstituted or N-substituted carbamyl, carboalkoxy, quinazolonyl, quinoxalinonyl, benzimidazolyl or benzothiazolyl and the rings A, B, the quinoline system and/... | 11/15/1988 |
| 4777168 | Bicyclic benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting parmacological activity, including anti-secretory and anti-ulcerogenic activity, pharaceutical compositions comprising these compounds, and methods for the treatment of ga... | 10/11/1988 |
| 4764217 | Novel compositions based on isoindoline pigments Composition containing (a) an isoindoline pigment of the formula I ##STR1## and (b) a compound of the formula II ##STR2## Pigment mixtures of this kind, in particular when used in paints, are distinguished in particular by increased tinctorial... | 08/16/1988 |
| 4751314 | Preparation of tetrachloro-3-iminoisoindolin-1-one Tetrachloro-3-iminosisoindolin-1-one (I) or its alkali metal salt (Ia) is prepared by reacting tetrachloro-ortho-phthalodinitrile with lithium hydroxide, sodium hydroxide and/or potassium hydroxide in substantially anhydrous tert-butanol and, if desired, ... | 06/14/1988 |
| 4746740 | Isoindoline colorants Isoindoline colorants of the formula ##STR1## where the radicals R independently of one another are each methyl or ethyl, give neutral yellow colorations when incorporated into surface coatings. The colorations do not darken on weathering and, compar... | 05/24/1988 |
