Class 548/470 - The ring nitrogen is bonded directly to two ring carbons of the same cyclo which carbons are members of one cyclo only (i.e., isoindoles or isoindolenines)

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the ring nitrogen is bonded directly to
No. of patents: 112
Last issue date: 09/06/2011

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Number	Title	Issue Date
8013171	Axially asymmetric ester compound and production method thereof To provide an axially asymmetric optically active biaryl ester compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. There is provided a method for producing an axially asymmetric ester compo...	09/06/2011
7884219	Crystalline forms of [3-(4- {2-butyl- 1 -[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine The present invention relates to crystalline forms of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethylamine (“COMPOUND I”) useful in the treatment of RAGE mediated diseases. ...	02/08/2011
7847107	Asymmetric reduction method The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-he...	12/07/2010
7482472	Substituted isoindoles and their use The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and methods of using them for the...	01/27/2009
7417063	Bicyclic heterocycles useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, L1, L2, X1, X2,...	08/26/2008
7414139	Catalytic antioxidants and methods of use The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some em...	08/19/2008
7399868	4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B	07/15/2008
7390908	Compounds effecting glucokinase The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or preventio...	06/24/2008
7378438	Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders The present invention relates to multifunctional β-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and their use for the treatment of respiratory diseases involving airway obstruction, such as asthma and chronic bron...	05/27/2008
7268147	Compounds useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds accord...	09/11/2007
7262208	Hydroxypropyl amides for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the...	08/28/2007
7173058	Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel compounds, pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof, pharmaceutical compositions of these compounds, and methods of using these comp...	02/06/2007
7160917	Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof The present invention relates to spirobenzofuran lactam derivatives of the formula I which are formed during fermentation by the microorganism Stachybotris atra ST002348, DSM 14952, processes for their pre...	01/09/2007
7098235	Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds Prodrugs of glycogen phosphorylase inhibiting compounds are provided which are useful in treating diabetes, having the formula I G(—O2CR′)m(—OH)n(—O2C(CH2)pCH3)q	08/29/2006
7081466	2-aroylimidazole compounds for treating cancer Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstitut...	07/25/2006
7034048	Gastrin and cholecystokinin receptor ligands (III) Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R5)—(R5 being selected from H, Me, Et, Pr, Bn, OH and —CH2COOR	04/25/2006
7008636	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ...	03/07/2006
6967196	Sulfonamide compounds and uses thereof In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substit...	11/22/2005
6900194	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of Respiratory Diseases, pharmaceutical compositions containing them, and a...	05/31/2005
6846832	2,3-dihydro-isoindol-1-one derivatives 2,3-Dihydro-isoindol-1-one derivatives, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them, for the prevention and treatment of diseases which are mediated by monoamine oxidase B. ...	01/25/2005
6806285	5-Hydroxyl indole derivatives for treating glaucoma Novel 3-(2-aminopropyl)-H-indol-5-ols useful for lowering and controlling IOP and treating glaucoma are disclosed. ...	10/19/2004
6743919	2-aroylimidazole compounds for treating cancer Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z1	06/01/2004
6689770	Aryl sulfonyls as factor Xa inhibitors The present application describes aryl sulfonyls of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa inhibitors....	02/10/2004
6673784	Electrophilic ketones for the treatment of herpesvirus infections A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein each of R1, R2, and R3 is independently selected f...	01/06/2004
6552065	Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties....	04/22/2003
6528663	Methods for the preparation of 4-chlorophthalic anhydride A method for the synthesis of substituted phthalic anhydrides (IV) ##STR1## wherein R' is a halogen, aromatic or aliphatic group comprising 1-18 carbons, hydrogen or nitro group is the transimidation between a substituted N-alkyl phthalimide (V) ##ST...	03/04/2003
6353014	15-ketal postaglandins for the treatment of glaucoma or ocular hypertension A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: ##STR1##...	03/05/2002
6350754	3-(cycloalkanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors The present invention relates to novel 3-(cycloalkano-heteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be usefu...	02/26/2002
6320058	Process for the preparation of isoindoline Process for the industrial synthesis of isoindoline by catalytic hydrogenation of phthalonitrile, and its application in the synthesis of 2-(S)-benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)-butyric acid, its pharmaceutically acceptable salts and its hydrates...	11/20/2001
6262060	Azacycloalkane derivatives, preparation and therapeutic application The invention relates to azacycloalkane derivatives, to pharmaceutical compositions containing them, to processes for preparing them, and to methods for the treatment of hyperglycaemia, diabetes, obesity or inflammation utilizing them....	07/17/2001
6222047	Pyrocarbonic acid diesters and the preparation and use thereof The invention relates to the preparation of pyrocarbonic acid diesters by an improved process and to the novel pyrocarbonic acid diesters prepared according to said process as well as to the use thereof. The core of the invention is a process for the preparati...	04/24/2001
6093832	Diiminoisoindoline compound and the process for producing the compound and use thereof The invention relates to novel phthalocyanine compounds, their intermediates and a process for their preparation. The inventive phthalocyanine compound absorbs in the near infrared region of the spectrum with a high absorption coefficient which features h...	07/25/2000
6060606	Dipyrromethene metal chelate compounds An optical recording medium having at least a recording layer and a reflective layer on a substrates, the said recording layer contains a dipyrromethene metal chelate compound obtained from a dipyrromethene compound represented by the general formula (1) ...	05/09/2000
6017471	Colorants and colorant modifiers A light-stable colored composition which includes a colorant and a radiation transorber. The colorant, in the presence of the radiation transorber, is adapted, upon exposure of the transorber to specific, narrow bandwidth radiation, to be mutable. The rad...	01/25/2000
6018054	7-isoindolinyl-quinolone derivatives and 7-isoindolinyl-naphthyridone derivatives The invention relates to intermediate compounds for preparing novel quinolone derivatives- and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antib...	01/25/2000
6004991	Acylated derivatives of melationin and its analogues, useful as medicaments The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in particular or the treatment of complaints associated with...	12/21/1999
5994379	Bisaryl COX-2 inhibiting compounds, compositions and methods of use The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically acceptable salts and esters thereof....	11/30/1999
5939268	Combinatorial libraries of molecules and methods for producing same This invention features methods of synthesizing combinatorial libraries of chemical compounds, and combinatorial libraries of chemical compounds formed by the methods of this invention. Specifically, Diels-Alder chemistry is utilized to generate libraries...	08/17/1999
5929106	Endothelin receptor antagonists Dihydroisoindole compounds of formula (I), wherein the substituents are as defined herein, are disclosed as being useful as endothelin receptor antagonists. The compounds are applied in the treatment of cardiovascular and renal diseases. ##STR1##...	07/27/1999
5889185	Method of synthesizing isoindolequinones and derivatives thereof A method of synthesizing isoindolequinones comprising the step of reacting a 2,3-di(ethynyl)hydroquinone with a hydride selected from the group consisting of Group 15 and Group 16 hydrides, wherein said step of reacting takes place in an oxygen free envir...	03/30/1999

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Class 548/470 - The ring nitrogen is bonded directly to two ring carbons of the same cyclo which carbons are members of one cyclo only (i.e., isoindoles or isoindolenines)