Celebrity Inventors
Walt Disney was no Mickey Mouse inventor. He devised a serious animation camera which he patented. With the device, his company created "Snow White".
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8426612 | Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletrip... | 04/23/2013 |
| 7572924 | Pyrrole substituted 2-indolinone protein kinase inhibitors The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related c... | 08/11/2009 |
| 7402606 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle ... | 07/22/2008 |
| 7399868 | 4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B | 07/15/2008 |
| 7368072 | Photochromic contact lenses and methods of manufacturing Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a ca... | 05/06/2008 |
| 7361682 | Indole derivatives as H3 inverse agonists The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable ... | 04/22/2008 |
| 7320826 | Photochromic articles with reduced temperature dependency and methods for preparation Described are photochromic articles that include a substrate, a temperature dependent reducing amount of at least one organic photochromic material (b) that changes from more absorbing to less absorbing of radiation in its activating spectral absorbance as the tempe... | 01/22/2008 |
| 7261843 | Photochromic optical article Describes a photochromic article, e.g., an ophthalmic photochromic plastic article, such as a lens, in which the article includes (1) a rigid substrate, e.g., a transparent substrate such as a glass or organic polymeric substrate, as for example, a thermoset or ther... | 08/28/2007 |
| 7262295 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles Described are photochromic materials of indeno [2′,3′:3,4]naphtho[1,2-b]pyran structure, characterized in that they have a nitrogen or sulfur containing substituent at the 11-position ring atom, are substantially free of spiro-substituents at the 13-position and... | 08/28/2007 |
| 7238723 | Indole derivatives The present invention provides eletriptan hydrobromide monohydrate of the formula (I): together with processes for preparing, uses of, and compositions containing, said monohydrate. ... | 07/03/2007 |
| 7202265 | Indolinone combinatorial libraries and related products and methods for the treatment of disease The present invention relates to organic molecules capable of modulating, regulating and/or inhibiting protein kinase signal transduction. Such compounds are useful for the treatment of diseases related to unregulated protein kinase signal transduction, including ce... | 04/10/2007 |
| 7186709 | Dihydropyrancarboxamides and uses thereof The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R1–R... | 03/06/2007 |
| 7179910 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related c... | 02/20/2007 |
| 7173048 | Indolyl derivatives as liver-X-receptor (LXR) modulators The invention relates to compounds of formula (I): and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, wherein R1, R2, R3, R4, R5... | 02/06/2007 |
| 7166357 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation Described are photochromic articles that include a substrate and a photochromic amount of at least one organic photochromic material (b) represented by graphic formula XIII adapted to change from an unactivated state to an activated state by exposure to radiation su... | 01/23/2007 |
| 7164030 | Process The present invention provides an improved process for the preparation of α-polymorphic eletriptan hydrobromide. ... | 01/16/2007 |
| 7157577 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions ... | 01/02/2007 |
| 7148249 | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, ... | 12/12/2006 |
| 7147889 | Organic photochromic compositions of improved kinetic performance Described are imbibition compositions that incorporate kinetic enhancing additive(s) into photochromic polymeric host material. Kinetic enhancing additives include organic polyol(s), epoxy-containing compound(s) or a mixture thereof that improves the performance of ... | 12/12/2006 |
| 7125905 | Pyrrole substituted 2-indolinone protein kinase inhibitors The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related c... | 10/24/2006 |
| 7119209 | Process for preparing indolinone derivatives The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process. ... | 10/10/2006 |
| 7119090 | Pyrrole substituted 2-indolinone protein kinase inhibitors The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of prot... | 10/10/2006 |
| 7112603 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to a... | 09/26/2006 |
| 7105563 | Indolinone derivatives and their use in treating disease-states such as cancer Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are discl... | 09/12/2006 |
| 7094368 | Pyrano-quinolines, pyrano-quinolinones, combinations thereof, photochromic compositions and articles Described are compositions of at least one material represented by a pyrano[3,2-c]quinoline structure, a pyrano[3,2-c]quinolinone structure or mixtures thereof. The pyrano[3,2-c]quinoline structure is characterized by having a nitrogen atom at the 6-position ring at... | 08/22/2006 |
| 7091220 | Substituted indole Mannich bases The present invention relates to substituted indole Mannich bases, processes of preparing substituted indole Mannich base, a medicament containing the same, and a pharmaceutical composition containing the same. ... | 08/15/2006 |
| 7053113 | Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases ... | 05/30/2006 |
| 7030214 | Ureins derived from α, ω, diamino acids and process for their preparation Ureins are obtained by reaction, in basic medium, between an Nω-(aryloxycarbonyl)diamino acid and a compound containing a free amino group. The chirality of the compounds is outstandingly well preserved. ... | 04/18/2006 |
| 7008943 | 1-(Pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention is directed to 1-pyrrolidin-1-ylmethyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related t... | 03/07/2006 |
| 6939565 | Protease inhibitors of the coagulation cascade isolated from Dysidea sponges The present invention is directed toward a composition comprising a compound isolated from Dysidea species sponges that is capable of inhibiting serine proteases of the coagulation cascade. In particular, this composition inhibits the TF/VIIa complex of the c... | 09/06/2005 |
| 6930124 | Compounds derived from oxindoles and their therapeutic application in cancer treatment The invention relates to compounds of formula (I) in which R5 is chosen from the group consisting of: in which R2 is a C1-C3 a... | 08/16/2005 |
| 6914145 | Acylation process The present invention is concerned with the acylation of indoles, specifically the preparation of 3-acylated indoles which may be further treated to provide indoles having an alternative substituent at the 3-position. ... | 07/05/2005 |
| 6906093 | Indolinone combinatorial libraries and related products and methods for the treatment of disease The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 06/14/2005 |
| 6852751 | Difluorobutyric acid metalloprotease inhibitors Compounds according to the following Formula (I): are effective in treating conditions characterized by excess metalloprotease activity. ... | 02/08/2005 |
| 6846818 | Selective inhibitors of cyclooxygenase-2 The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the inventio... | 01/25/2005 |
| 6797725 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related c... | 09/28/2004 |
| 6784167 | 17-beta-hydroxysteroid dehydrogenase-II inhibitors 17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group —C(R4)(R6)Y are oriented cis to each other; W represents O or S; R... | 08/31/2004 |
| 6750240 | Methods of using bis-indolylquinones The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The inv... | 06/15/2004 |
| 6716837 | Heterocyclic compounds for the treatment of migraine Described herein are compounds useful in the treatment of migraine, which have the general formula: wherein: W is a CH group or a N atom; Z is N or C—R4; B and D are selected independently from CH and N, with th... | 04/06/2004 |
| 6716869 | Protease inhibitors of the coagulation cascade isolated from Dysidea sponges The present invention is directed toward a composition comprising a compound isolated from Dysidea species sponges that is capable of inhibiting serine proteases of the coagulation cascade. In particular, this composition inhibits the TF/VIIa complex of the coagulat... | 04/06/2004 |
