Did You Know...
...that the Eveready Battery began as an invention called the "electric flowerpot," which was a tube with a battery and light bulb inside? The idea was to fasten this gizmo to the side of a flowerpot so it would illuminate the flowers from the bottom. The idea died on the vine and the businessman who licensed the flower pot, Conrad Huber, was left with a pile of useless tubes -- until he found a way to market them as batteries to light the world!
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| Number | Title | Issue Date |
| 7943784 | Process for the preparation of almotriptan The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl)1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic a... | 05/17/2011 |
| 7598397 | Sulfonamide peri-substituted bicyclics for occlusive artery disease Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representa... | 10/06/2009 |
| 7405237 | Isoindoline compounds and methods of their use Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases and disorders mediated by PDE 4, using the compounds are also disclos... | 07/29/2008 |
| 7405300 | Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP) The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. Th... | 07/29/2008 |
| 7378438 | Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders The present invention relates to multifunctional β-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and their use for the treatment of respiratory diseases involving airway obstruction, such as asthma and chronic bron... | 05/27/2008 |
| 7375219 | Substituted indole compounds having NOS inhibitory activity The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other p... | 05/20/2008 |
| 7355054 | Indole derivatives The invention relates to 1-(R1)-2-(R2)-3-(Y—X—NH-A- or Z-A-)-4,5,6,7-R)0-4-indoles, and their acid addition salts where the compounds are basic, wherein A is C1-4 alkylene, X is >CH2, >C═O or >C═S, and t... | 04/08/2008 |
| 7250415 | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof of Formula I: P-M-M1I or a stereo... | 07/31/2007 |
| 7211632 | Perdeuterated polyiimides, their process of preparation and their use as materials which are transparent within the region from 2500 to 3500cm The present invention relates to a deuterated polyimide, the backbone of which comprises an alternation between: at least one repeat unit corresponding to the following formula (I): | 05/01/2007 |
| 7208505 | β3 adrenergic agonists The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity... | 04/24/2007 |
| 7138415 | Indolamid derivatives which possess glycogenphosphorylase inhibitory activity Heterocyclic amides of formula (1) wherein: is a single or double bond; A is phenylene or heteroarylene; m is 0, 1 or 2; n is 0, 1 or 2; R1 | 11/21/2006 |
| 7122538 | Sulfonamide derivatives as antipsychotic agents The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 | 10/17/2006 |
| 7112603 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to a... | 09/26/2006 |
| 7094800 | Cyanopyrrolidides, process for their preparation and their use as medicaments The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts, physiologically functional de... | 08/22/2006 |
| 6995262 | Use of acylsulfonamido-substituted polymethine dyes as fluorescene dyes and/or markers The invention relates to a novel polymethine dyes containing at least one acylsulfonamido group of the formula (I) in which n, Y, A and R have the meaning given in the claims, and at least one compound of the formulae ... | 02/07/2006 |
| 6989384 | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical ... | 01/24/2006 |
| 6962942 | Azacycloalkanone serine protease inhibitors The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds having F... | 11/08/2005 |
| 6933295 | Substituted isoindoles and the use thereof The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or tre... | 08/23/2005 |
| 6855710 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs The present invention relates to new substituted indolinones of general formula wherein X and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable... | 02/15/2005 |
| 6831178 | Process for preparation of sulfonamide derivatives and crystals thereof A process for the preparation of a compound of the formula (I′): which comprises reacting in a solvent a compound of the formula (III): wherein X is halogen, ... | 12/14/2004 |
| 6815093 | Light emitting materials based on indole skeleton An indole-based compound represented by Formula (1) disclosed herein is useful in forming a light emitting material for an organic electroluminescent device. The organic electroluminescent device has a multi-layered structure comprising a cathode, an anode and at le... | 11/09/2004 |
| 6812243 | Indole derivatives and their use for the treatment of malignant and other diseases based on pathological proliferation The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: pharmaceuticals containing them and their use for the treatment of malignant and other diseases based on pa... | 11/02/2004 |
| 6809098 | Compounds The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam... | 10/26/2004 |
| 6794406 | Indole derivatives The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments. ... | 09/21/2004 |
| 6787651 | Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-γ binding agents Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-γ mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis. ... | 09/07/2004 |
| 6787550 | Indole derivatives and their use for the treatment of osteoporosis amongst other applications A compound of formula (1) or a salt thereof, or a solvate thereof, wherein; R1 and R2 each independently represents C1-6alkoxy or halo; R3 and R4 | 09/07/2004 |
| 6765012 | 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 07/20/2004 |
| 6762180 | Substituted indolines which inhibit receptor tyrosine kinases Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1... | 07/13/2004 |
| 6750241 | Protein kinase inhibitors Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such com... | 06/15/2004 |
| 6743817 | Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists... | 06/01/2004 |
| 6740647 | Thrombin inhibitors Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, ... | 05/25/2004 |
| 6740649 | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE) The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected fro... | 05/25/2004 |
| 6727266 | Substituted tryptophan derivatives A compound of the formula (I): wherein: R1 is represented by the formula: wherein R4, R5, R6, R7 and R8 are ... | 04/27/2004 |
| 6716870 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to a... | 04/06/2004 |
| 6706735 | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 03/16/2004 |
| 6696574 | Processes and intermediates for preparing glycogen phosphorylase inhibitors The instant invention provides novel processes and intermediates useful in the preparation of certain N-(indole-2-carbonyl)-ଲ-alaninamide compounds, which compounds are glycogen phosphorylase inhibitors useful in the treatment of diseases such as hy... | 02/24/2004 |
| 6677367 | HIV protease inhibitors based on amino acid derivatives A compound selected from the group consisting of a compound of formula I ##STR1## a compound of formula II ##STR2## and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1 | 01/13/2004 |
| 6673790 | Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands The present invention relates to novel indolin-2-one derivatives of formula: ##STR1## to the preparation and to the pharmaceutical compositions comprising them. These compounds have an affinity for oxytocin receptors.... | 01/06/2004 |
| 6653312 | Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing same Amidine compounds of the formula ##STR1## wherein the substituents are defined as in the application useful as NO-synthase enzyme inhibitors.... | 11/25/2003 |
| 6638964 | Sulfonamide-containing indole compounds The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an ... | 10/28/2003 |
