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| Number | Title | Issue Date |
| 8148546 | Tetrahydrocarbazole derivatives as ligands of G-protein coupled receptors The present invention provides novel tetrahydrocarbazole compounds according to formula (I) as ligands of G-protein coupled receptors (GPCR) which are useful in the treatment and/or prophylaxis of physiological and/or pathological conditions in mammals mediated by G... | 04/03/2012 |
| 7442808 | Antidiabetic bicyclic compounds Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful a... | 10/28/2008 |
| 7375127 | Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) The present invention provides novel tetrahydrocarbazole derivatives which have improved properties and which can be employed as inhibitors of GPCRs. This results in the possibility of using the novel compounds to treat pathological conditions whose severity depends... | 05/20/2008 |
| 7351839 | Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives This invention provides processes for preparing compounds formula: wherein R is H, alkyl, acyl, aryl, aroyl or —C(O)R′; R′ is alkyl or aryl; R1, R2, R4 and R5 are H, —OH, ... | 04/01/2008 |
| 7250441 | Carbazole and cyclopentaindole derivatives to treat infection with Hepatitis C virus The invention is directed to a method of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: ... | 07/31/2007 |
| 7160909 | Cyclopenta[b]indole derivatives as sPLAinhibitors A novel class of tricyclic compounds of the following formula (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 01/09/2007 |
| 7122570 | Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR) This invention provides new tetrahydrocarbazole derivatives that act as ligands for G-protein-coupled receptors (GPCR), especially as antagonists of the gonadotropin-releasing hormone (GnRH). A pharmaceutical composition that contains these new tetrahydrocarbazole d... | 10/17/2006 |
| 6967215 | Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof Tetrahydrocarbazoles of formula where Q is —SO2—; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein, are useful as an... | 11/22/2005 |
| 6846840 | Cytotoxic N-unsubstituted indoles and cyclopent(B)indoles and method of making and using same The merits of N-unsubstituted indoles and cyclopent[b]indoles as DNA-directed reductive alkylating agents are described. These systems represent a significant departure from N-substituted and pyrrolo[1,2-α] fused systems such as the mitomycins and mitosenes. The cy... | 01/25/2005 |
| 6514984 | Treatment for alzheimer's disease A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA2 inhibitor.... | 02/04/2003 |
| 6410583 | Cyclopentanoindoles, compositions containing such compounds and methods of treatment Substituted cyclopentanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.... | 06/25/2002 |
| 6221884 | Carboxamides useful as 5-HT1F agonists The present invention provides novel 2-amino-1,2,3,4-tetrahydro-9H-carbazole-6-carboxamides and 3-amino-10H-cyclohepta[7,6-b]indole-7-carboxamides of Formula I: ##STR1## where R1, R2, R3 and n are as described in the ... | 04/24/2001 |
| 6037361 | Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase)... | 03/14/2000 |
| 5962501 | Enantiomer of carbazole derivative as 5-HT1-like agonists A (+) or (-) enantiomer of a compound of formula (I) wherein R4 is methyl or ethyl, or a salt, solvate, or hydtrate thereof, processes for preparing said compounds and pharmaceutical compostions containing them. Compounds of formula (+) are 5-H... | 10/05/1999 |
| 5917054 | Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists A (+) or (-) enantiomer of a compound of formula (I) wherein R4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT... | 06/29/1999 |
| 5892041 | Fused indolecarboxamides: dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: ##STR2## represents an aromatic or alicyclic ring; R1 and R2 are the same or different and represent h... | 04/06/1999 |
| 5827871 | Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof Use of a compound of general formula (I): ##STR1## wherein R1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C1-6 alkyl, C1-6 alkoxy, arylC1-6 alkoxy, --CO2 R4, --(CH | 10/27/1998 |
| 5618947 | Process of preparing enantiomers of carbazole derivatives A (+) or (-) enantiomer of a compound of formula (I) wherein R4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT... | 04/08/1997 |
| 5618948 | Process for preparing an enantiomer of a carbazole derivative A (+) or (-) enantiomer of a compound of formula (I) wherein R4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT... | 04/08/1997 |
| 5616603 | Enantiomers of carbazole derivatives as 5-HT1 -like agonists A (+)or (-) enantiomer of a compound of formula (I) wherein R4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT | 04/01/1997 |
| 5612331 | Tetrahydrocarbazole derivatives as 5-HT1-like agonists Compounds of formula (I), wherein R1 represents halogen, C1-4 alkyl, C1-4 alkoxy, hydroxy, NO2, --NR4 R5, R4 R5 NCO(CH2)m --, R4 R5 | 03/18/1997 |
| 5587486 | 1-amino-2-cyclohexene derivative and production process therefor 1-amino-2-cyclohexene compounds represented by the following formula (I): ##STR1## wherein the substituents are as defined in the specification, a process for preparing the compounds and their use as intermediates in the production of medicinal and a... | 12/24/1996 |
| 5451600 | Substituted tetrahydrobenzopyrrolylfuranoic acid derivatives as phospholipase A2 inhibitors Compounds of the formula ##STR1## wherein R is hydrogen, alkyl1-8, geminal alkyl1-3, unsubstituted or substituted aryl; X is alkylene, --CR1 .dbd.CR2 -- (E and/or Z), carbonyl, oxygen or sulfur, wherein one... | 09/19/1995 |
| 5416221 | Carbazolone derivatives The invention relates to carbazolone derivatives of the formula ##STR1## wherein A stands for a group of formula --CH2 --R (V), wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group; B represents ... | 05/16/1995 |
| 5223517 | Heterocyclically substituted cycloalkano[b]-indolesulphonamides Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or amidation, or by reaction of heterocyclically substituted hydr... | 06/29/1993 |
| 5210214 | Preparation of indolenines A process for preparing indolenines of the formula I ##STR1## where R1, R2 and R3 are independently of one another hydrogen, C1 -C20 -alkyl, C2 -C20 -alkenyl, C3 ... | 05/11/1993 |
| 5204374 | Cycloalkano(b)dihydroindoles and -indolesulphonamides substituted by heterocycles New cycloalkano[b]dihydroindoles and -indolesulphonamides, substituted by heterocycles, of the formula (I) ##STR1## in which R1, R2, R3 and R4 are identical or different and represent hydrogen, nitro, cyano... | 04/20/1993 |
| 5096897 | Antithrombotic substituted cycloalkano(b)dihydroindole- and -indole-sulphonamides Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R1, R2, R3 | 03/17/1992 |
| 5039670 | Antithrombotic substituted cycloalkano(B)dihydroindole- and -indole-sulphonamides and use Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R1, R2, R3 | 08/13/1991 |
| 5017597 | Cyclohept(B)indolealkanoic acids, pharmaceutical compositions and use Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet, aggregation, cerebral spasm, premature labor, ... | 05/21/1991 |
| 4988820 | Cycloalkano(1,2-B) indole-sulponamides Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## in which R1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, represents a group of the formula --S(O)m R3, in which R3 | 01/29/1991 |
| 4965258 | Cycloalkano(1,2-B)indole-sulphonamides, pharmaceutical compositions and use Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antoganize thromboxane A2.... | 10/23/1990 |
| 4906654 | Cyclohept[b]indoleakanoic acids, pharmaceutical compositions and use Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, s... | 03/06/1990 |
| 4904797 | Process of preparing cycloalkano(1,2-B)indole-sulphonamides Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A2.... | 02/27/1990 |
| 4827032 | Cycloalkyl-one-containing benzenesulphonamides Cycloalkanol[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A2.... | 05/02/1989 |
| 4775680 | Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, s... | 10/04/1988 |
| 4546193 | Antiarrhythmic cyclooct[b]indoles This invention provides a group of antiarrhythmic agents of the formula: ##STR1## in which R1 is --CO2 H, --CO2 (CH2)n --NR4 R5, --CONR6 R7, --NHCO2 | 10/08/1985 |
| 4292323 | Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof This application relates to phenyl-substituted 1,2,3,4-tetrahydrocarbazoles and to their use as anti-depressant agents useful in the treatment of mental depression of either endogenous or reactive nature.... | 09/29/1981 |
| 4257952 | 3-Amino-tetrahydrocarbazoles 3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduct... | 03/24/1981 |
| 4189171 | Marking systems containing 3-aryl-3-heterylphthalides and 3,3-bis(heteryl)phthalides 3-Aryl-3-indolylphthalides, 3-aryl-3-pyrrolylphthalides and 3-aryl-3-carbazolylphthalides prepared by interaction of the appropriate 2-(heteroaryl)carbonylbenzoic acid and the appropriate phenylamine, and 3,3-bis(indolyl)phthalides prepared by the interac... | 02/19/1980 |
