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Patent No. 6650315

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A mouse device for use as an input device of a computer is provided that includes a housing in which recording paper is loadable, and a printer unit provided within the housing for printing on the recording paper print information received from the computer.

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Class 548/432 - Pyrano(3,4-b)indoles or thiopyrano(3,4-b) indoles (including hydrogenated)


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the tricyclo ring system has the following
No. of patents: 71
Last issue date: 01/01/2008


1    
NumberTitleIssue Date
7314886Tetrahydropyrano-indole derivatives
Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. ...
01/01/2008
7217730Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus
The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: Wherei...
05/15/2007
7211599Use of etodolac to treat hyperplasia
The present invention provides a therapeutic method to treat non-malignant diseases characterized by the excessive tissue growth, e.g., hyperplastic diseases, comprising administering to a mammal (e.g., human) afflicted with excessive tissue growth, an effective amo...
05/01/2007
7151100Indole compounds useful for the treatment of cancer
The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments. ...
12/19/2006
7078533Method for the racemization of etodolic acid
A method for the resolution of etodolic acid by crystallization of its salt with optically active 1-phenylethylamine and subsequent recovery of the (R,S) etodolic acid from the mother liquors of crystallization by racemization and crystallization is described. ...
07/18/2006
6964979R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
The invention is directed to a compound and a pharmaceutical composition of the formula: Wherein substitutions at R1, R2 , R3-R12, and Y are set forth in the specification....
11/15/2005
6921772Methods and compositions for the treatment of chronic lymphocytic leukemia
The level of the leukemic lymphocytes in patients suffering from chronic lymphocytic leukemia (CLL) is reduced by the administration of certain indole or carbazole compounds, such as the nonsteroidal anti-inflammatory drug etodolac or related indole or carbazole com...
07/26/2005
6514984Treatment for alzheimer's disease
A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA2 inhibitor....
02/04/2003
6469171Syntheses of a variety of lamellarin compounds and analogues
The present invention relates to methods for preparing a variety of Lamellarin compounds and analogues via a synthetic intermediate, which methods involved the step of performing an intramolecular cyclization of a compound of Formula (I) to produce compou...
10/22/2002
6331638Process for the preparation of 1,8-disubstituted-1,3,4,9-tetrahydropyrano (3,4-B)-indole-1-acetic acid esters
A process for the preparation of the esters of 1,8-disubstituted-1,3,4,9-tetrahydropyrano (3,4-b)-indole-1-acetic acid is delineated....
12/18/2001
6297260Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least o...
10/02/2001
6177440Substituted tricyclics
A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock....
01/23/2001
6110955Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating b...
08/29/2000
6071946Tricyclic urea compounds
A compound selected from those of formula (I): ##STR1## in which A, Y, R1, R2 and R3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful for treating a mammal aff...
06/06/2000
6066741Process for the preparation of etodolac
Process for the preparation of etodolac, comprising the following steps: a) reacting 7-ethyl-tryptophol of formula (II) with methyl 3-oxo-pentanoate of formula (III) thereby obtaining methyl 1,8-diethyl-1,3,4,9-tetrahydropyrano [3,4-bis] indole-1-acetate of fo...
05/23/2000
6057347Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that d...
05/02/2000
5998461Tricyclic amide compounds
This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system....
12/07/1999
5756320Bioactive substances K93-0711 I-1 and I-2 and process for production thereof
Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium....
05/26/1998
57505562-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano-›2,3-E!indol-8-ones and derivatives
Compounds of Formula I are selective autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems: ##STR1## in which X is --(CH2)n --; n is 1-3; R1 is hydrogen, alkyl, hydroxyalk...
05/12/1998
5696130Tricyclic steroid receptor modulator compounds and methods
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f...
12/09/1997
5639778Indoletetralins having dopaminergic activity
A compound of formula (I) and pharmaceutically acceptable salts thereof, where Z is R3 and X and Y form (a), or X is R3 and Y and Z form (a) or (b); R1 and R2 are independently hydrogen, C1-6 alkyl, C...
06/17/1997
5621000Nitric esters having a pharmacological activity and process for their preparation
Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation. ##STR1##...
04/15/1997
55999463-(2-trialkylsilyloxy)ethyl-7-ethyl-1H-indoles and method for their preparation
The present invention relates to novel trialkylsilyloxy derivatives of 7-ethyltryptophol useful in the preparation of etodolac, and methods of making them, and methods of using them to prepare etodolac....
02/04/1997
5585499Cyclopropylbenzindole-containing cytotoxic drugs
Novel cytotoxic agents comprising a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described. These cytotoxic agents have therapeutic use because the...
12/17/1996
5578734Method for the preparation of S-(+)-ethodolic acid and saline derivatives
Method for optically resolving an enantiomeric mixture of ethodolic acid to produce the S (+) enantiomer is provided wherein the enantiomeric mixture is salified with at least 0.5 moles per mole of a mixture of alpha-(+)-phenethylamine enantiomers in an o...
11/26/1996
5491163(Thia)cycloalkyl[B]indoles
The invention relates to a compound selected from those of formula (I): ##STR1## in which R1, R2, R3 and A are as defined in the description, and medicinal product containing the same in order to treat a mammal afflic...
02/13/1996
5330981Arylalkyl esters of 4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid having therapeutical activity
This application describes 3-arylalkyl esters of 4,5-dihydro-9,10-dioxo-2-anthracenecarboxylic acid and a process for making them. Also described is a method of using the compounds in the treatment of arthritis....
07/19/1994
5137909Indole derivative and method of production thereof
An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R1, R2, R3, and R4 may ...
08/11/1992
5128363Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for their preparation and use, are disclosed. The derivatives are...
07/07/1992
5071853Polycyclic amines useful as cerebrovascular agents
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed....
12/10/1991
5030646Novel tricyclic indole compound
The invention relates to compounds of general formula: ##STR1## in which A, B, G, D which may be identical or different, each denote a hydrogen atom or a halogen atom, a lower alkoxy group or alternatively a lower alkyl group optionally substituted w...
07/09/1991
4960902Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for their preparation and use, are disclosed. The derivatives are...
10/02/1990
4925955Resolution of (1S,4R)-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl) pyrano[3,4-B]indole-1-acetic acid using brucine
This invention relates to a process for resolving (&#b1;)-cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole- 1-acetic acid (pemedolac) usinig brucine to obtain the corresponding (1S,4R)-eutomer. Said eutomer is useful as an analgesic....
05/15/1990
4910318Tetrahydrothiopyrano(3,2-b)-indole derivatives
Tetrahydrothiopyrano[3,2-b]indole derivatives represented by the formula I: ##STR1## wherein R1 is hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, phenyl-C1-4 alkyl, C2-5 alkanoyl, or ...
03/20/1990
4897493Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity....
01/30/1990
4886886Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and metho...
12/12/1989
4855445Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods ...
08/08/1989
4826994Production of substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic acids
Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are use...
05/02/1989
4824961Production of substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity....
04/25/1989
4822781Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods ...
04/18/1989
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