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| Number | Title | Issue Date |
| 7314886 | Tetrahydropyrano-indole derivatives Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. ... | 01/01/2008 |
| 7217730 | Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: Wherei... | 05/15/2007 |
| 7211599 | Use of etodolac to treat hyperplasia The present invention provides a therapeutic method to treat non-malignant diseases characterized by the excessive tissue growth, e.g., hyperplastic diseases, comprising administering to a mammal (e.g., human) afflicted with excessive tissue growth, an effective amo... | 05/01/2007 |
| 7151100 | Indole compounds useful for the treatment of cancer The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments. ... | 12/19/2006 |
| 7078533 | Method for the racemization of etodolic acid A method for the resolution of etodolic acid by crystallization of its salt with optically active 1-phenylethylamine and subsequent recovery of the (R,S) etodolic acid from the mother liquors of crystallization by racemization and crystallization is described. ... | 07/18/2006 |
| 6964979 | R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease The invention is directed to a compound and a pharmaceutical composition of the formula: Wherein substitutions at R1, R2 , R3-R12, and Y are set forth in the specification.... | 11/15/2005 |
| 6921772 | Methods and compositions for the treatment of chronic lymphocytic leukemia The level of the leukemic lymphocytes in patients suffering from chronic lymphocytic leukemia (CLL) is reduced by the administration of certain indole or carbazole compounds, such as the nonsteroidal anti-inflammatory drug etodolac or related indole or carbazole com... | 07/26/2005 |
| 6514984 | Treatment for alzheimer's disease A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA2 inhibitor.... | 02/04/2003 |
| 6469171 | Syntheses of a variety of lamellarin compounds and analogues The present invention relates to methods for preparing a variety of Lamellarin compounds and analogues via a synthetic intermediate, which methods involved the step of performing an intramolecular cyclization of a compound of Formula (I) to produce compou... | 10/22/2002 |
| 6331638 | Process for the preparation of 1,8-disubstituted-1,3,4,9-tetrahydropyrano (3,4-B)-indole-1-acetic acid esters A process for the preparation of the esters of 1,8-disubstituted-1,3,4,9-tetrahydropyrano (3,4-b)-indole-1-acetic acid is delineated.... | 12/18/2001 |
| 6297260 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least o... | 10/02/2001 |
| 6177440 | Substituted tricyclics A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.... | 01/23/2001 |
| 6110955 | Metabolically stabilized oxyalkylene esters and uses thereof This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating b... | 08/29/2000 |
| 6071946 | Tricyclic urea compounds A compound selected from those of formula (I): ##STR1## in which A, Y, R1, R2 and R3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful for treating a mammal aff... | 06/06/2000 |
| 6066741 | Process for the preparation of etodolac Process for the preparation of etodolac, comprising the following steps: a) reacting 7-ethyl-tryptophol of formula (II) with methyl 3-oxo-pentanoate of formula (III) thereby obtaining methyl 1,8-diethyl-1,3,4,9-tetrahydropyrano [3,4-bis] indole-1-acetate of fo... | 05/23/2000 |
| 6057347 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that d... | 05/02/2000 |
| 5998461 | Tricyclic amide compounds This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.... | 12/07/1999 |
| 5756320 | Bioactive substances K93-0711 I-1 and I-2 and process for production thereof Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium.... | 05/26/1998 |
| 5750556 | 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano-2,3-E!indol-8-ones and derivatives Compounds of Formula I are selective autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems: ##STR1## in which X is --(CH2)n --; n is 1-3; R1 is hydrogen, alkyl, hydroxyalk... | 05/12/1998 |
| 5696130 | Tricyclic steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 12/09/1997 |
| 5639778 | Indoletetralins having dopaminergic activity A compound of formula (I) and pharmaceutically acceptable salts thereof, where Z is R3 and X and Y form (a), or X is R3 and Y and Z form (a) or (b); R1 and R2 are independently hydrogen, C1-6 alkyl, C... | 06/17/1997 |
| 5621000 | Nitric esters having a pharmacological activity and process for their preparation Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation. ##STR1##... | 04/15/1997 |
| 5599946 | 3-(2-trialkylsilyloxy)ethyl-7-ethyl-1H-indoles and method for their preparation The present invention relates to novel trialkylsilyloxy derivatives of 7-ethyltryptophol useful in the preparation of etodolac, and methods of making them, and methods of using them to prepare etodolac.... | 02/04/1997 |
| 5585499 | Cyclopropylbenzindole-containing cytotoxic drugs Novel cytotoxic agents comprising a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described. These cytotoxic agents have therapeutic use because the... | 12/17/1996 |
| 5578734 | Method for the preparation of S-(+)-ethodolic acid and saline derivatives Method for optically resolving an enantiomeric mixture of ethodolic acid to produce the S (+) enantiomer is provided wherein the enantiomeric mixture is salified with at least 0.5 moles per mole of a mixture of alpha-(+)-phenethylamine enantiomers in an o... | 11/26/1996 |
| 5491163 | (Thia)cycloalkyl[B]indoles The invention relates to a compound selected from those of formula (I): ##STR1## in which R1, R2, R3 and A are as defined in the description, and medicinal product containing the same in order to treat a mammal afflic... | 02/13/1996 |
| 5330981 | Arylalkyl esters of 4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid having therapeutical activity This application describes 3-arylalkyl esters of 4,5-dihydro-9,10-dioxo-2-anthracenecarboxylic acid and a process for making them. Also described is a method of using the compounds in the treatment of arthritis.... | 07/19/1994 |
| 5137909 | Indole derivative and method of production thereof An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R1, R2, R3, and R4 may ... | 08/11/1992 |
| 5128363 | Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for their preparation and use, are disclosed. The derivatives are... | 07/07/1992 |
| 5071853 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 12/10/1991 |
| 5030646 | Novel tricyclic indole compound The invention relates to compounds of general formula: ##STR1## in which A, B, G, D which may be identical or different, each denote a hydrogen atom or a halogen atom, a lower alkoxy group or alternatively a lower alkyl group optionally substituted w... | 07/09/1991 |
| 4960902 | Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for their preparation and use, are disclosed. The derivatives are... | 10/02/1990 |
| 4925955 | Resolution of (1S,4R)-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl) pyrano[3,4-B]indole-1-acetic acid using brucine This invention relates to a process for resolving (b1;)-cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole- 1-acetic acid (pemedolac) usinig brucine to obtain the corresponding (1S,4R)-eutomer. Said eutomer is useful as an analgesic.... | 05/15/1990 |
| 4910318 | Tetrahydrothiopyrano(3,2-b)-indole derivatives Tetrahydrothiopyrano[3,2-b]indole derivatives represented by the formula I: ##STR1## wherein R1 is hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, phenyl-C1-4 alkyl, C2-5 alkanoyl, or ... | 03/20/1990 |
| 4897493 | Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity.... | 01/30/1990 |
| 4886886 | Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and metho... | 12/12/1989 |
| 4855445 | Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods ... | 08/08/1989 |
| 4826994 | Production of substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic acids Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are use... | 05/02/1989 |
| 4824961 | Production of substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity.... | 04/25/1989 |
| 4822781 | Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods ... | 04/18/1989 |