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| Number | Title | Issue Date |
| 7718810 | Supports for oligomer synthesis Universal linkers, their facile processes of manufacture and methods of using the same are provided. ... | 05/18/2010 |
| 7622596 | Thermally cleavable surfactants Two new surfactant molecules are reported which contain thermally labile Diels-Alder adducts connecting the polar and non-polar sections of each molecule. The two surfactants possess identical non-polar dodecyl tail segments but exhibit different polar headgroups. T... | 11/24/2009 |
| 7351837 | Thermally cleavable surfactants without deprotonation The present invention describes surfactants of formula (I), wherein R, RN, and m are defined herein, processes for their preparation, and methods for their decomposition. ... | 04/01/2008 |
| 7208566 | Imide-linked maleimide and polymaleimide compounds The invention is based on the discovery that a remarkable improvement in the performance of maleimide thermosets can be achieved through the incorporation of imide-extended mono-, bis-, or polymaleimide compounds. These imide-extended maleimide compounds are readily... | 04/24/2007 |
| 7202264 | Supports for oligomer synthesis Universal linkers, their facile processes of manufacture and methods of using the same are provided. ... | 04/10/2007 |
| 7151116 | Apoptolidin analogs and derivatives for inducing apoptosis in transformed cells The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof; selectively functionalized apoptolidin derivatives and stereoisomers thereo... | 12/19/2006 |
| 7022861 | Thermally cleavable surfactants Two new surfactant molecules are reported which contain thermally labile Diels-Alder adducts connecting the polar and non-polar sections of each molecule. The two surfactants possess identical non-polar dodecyl tail segments but exhibit different polar headgroups. T... | 04/04/2006 |
| 6962942 | Azacycloalkanone serine protease inhibitors The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds having F... | 11/08/2005 |
| 6960474 | Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and u... | 11/01/2005 |
| 6960667 | Fluorescent maleimides and uses thereof The present invention is directed to maleimides and preparation of compounds of the formula I wherein R1 and R2 independently from each other stand for | 11/01/2005 |
| 6815440 | Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is invol... | 11/09/2004 |
| 6706750 | Indole derivatives process for their preparation, pharmaceutical compositions containing them and their medicinal application A chemical compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4, R6 and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, ... | 03/16/2004 |
| 6699899 | Substituted acylhydroxamic acids and method of reducing TNF levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate.... | 03/02/2004 |
| 6627604 | Memno peptides, process for their preparation and use thereof The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8 and (A)n have the meanin... | 09/30/2003 |
| 6624171 | Substituted aza-oxindole derivatives Substituted aza-oxindole derivatives useful as cyclin dependent kinase 11 inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiati... | 09/23/2003 |
| 6177440 | Substituted tricyclics A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.... | 01/23/2001 |
| 6162822 | Bisimide compounds A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1, X and Y, which may be identical or different, represent hydrogen or halogen or alky, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylam... | 12/19/2000 |
| 6080872 | Cycloaliphatic epoxy compounds Cycloaliphatic epoxy compounds represented by general formula (I): ##STR1## wherein R1 and R2 are hydrogen atoms, or R1 and R2 taken together represent an epoxy group, R3 and R4 are the sam... | 06/27/2000 |
| 6071946 | Tricyclic urea compounds A compound selected from those of formula (I): ##STR1## in which A, Y, R1, R2 and R3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful for treating a mammal aff... | 06/06/2000 |
| 5998461 | Tricyclic amide compounds This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.... | 12/07/1999 |
| 5968640 | Conductive, thermally stable oligomers The morphology of multidimensional, thermally stable oligomers is combined with the inclusion of charge carrier linkages within the polymer arms to produce thermally stable advanced composites from cured oligomers that are conductive or semiconductive if ... | 10/19/1999 |
| 5886192 | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo2.2.1!heptane compound and the preparation of 2-azabicyclo2.2.1!heptane compounds A method for the preparation of a lactam compound of formula ##STR1## wherein R'1 and R"1 independently are acyl or aroyl, or taken together form an optionally substituted methylene, and G1 is hydrogen or an amino pro... | 03/23/1999 |
| 5854275 | Cyclic imide derivatives The invention relates to a compound of the formula I ##STR1## wherein R1 is a cyclic imide group and X, Y, R2, and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing, and... | 12/29/1998 |
| 5827799 | Compounds and herbicides containing same as active components An object of the invention is to provide herbicides which are completely selective to crops such as paddy rice, soybeans and cotton and have an excellent herbicidal activity on weeds. The invention relates to ether compounds of the general formula (I) ##S... | 10/27/1998 |
| 5817689 | Indole derivatives having a 2-phenyl-ethanolamino-substituted lower alkyl group at the 2-or 3-position thereof An indole derivative of the formula: ##STR1## wherein R1 is lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, lower alkoxycarbonyl, phenyl-lower alkoxy, lower alkyl being optionally substituted by hydroxy, di-lower ... | 10/06/1998 |
| 5811449 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 09/22/1998 |
| 5807884 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 09/15/1998 |
| 5783596 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty... | 07/21/1998 |
| 5777138 | Ring-opening amidation process A process for amidating a 2-azabicyclo2.2.1!heptan-3-one or a 2-azabicyclo2.2.1!hept-5-en-3-one by reaction with an amine, to form the corresponding ring-opened amide, is modified by the addition of an additive that accelerates the rate of reaction to... | 07/07/1998 |
| 5776962 | Lactone compounds for treating patient with precancerous lesions Substituted lactone compounds are useful in the treatment of precancerous lesions and neoplasms.... | 07/07/1998 |
| 5773231 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 06/30/1998 |
| 5756532 | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino2 3-E!-indol-8-ones and derivatives The compounds of formula I: ##STR1## wherein R1 and R2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R1 and R2, taken together, are benzylidene optionally substituted with R3 as defin... | 05/26/1998 |
| 5750351 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 05/12/1998 |
| 5693741 | Liquid molding compounds Low molecular weight resins that usually are aliphatic and that include crosslinking thermal functional groups are useful as liquid molding compounds for reaction injection molding or resin transfer molding. The compounds eliminate the need to handle solv... | 12/02/1997 |
| 5670649 | Derivatives of 2-azabicyclo2.2.1!heptane, their preparation and their application Novel derivatives of 1R- or 1S-2-azabicyclo2.2.1!heptane with the general formula (I) or (I'), their preparation and their application. ##STR1## In the general formulas (I) and (I'), R represents a hydrogen atom or a group with the formula ##S... | 09/23/1997 |
| 5631383 | Derivatives of 2-azabicyclo[2.2.1]heptane, their preparation and their application Novel derivatives of 1R- or 1S-2-azabicyclo[2.2.1]heptane with the general formula (I) or (I'), their preparation and their application; ##STR1##... | 05/20/1997 |
| 5618946 | 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same The present invention relates to novel 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates which may be used to prepare a final anti-thrombotic, anti-vasospastic product, and to methods for preparing the same.... | 04/08/1997 |
| 5610317 | Multiple chemically functional end cap monomers Thermomechanical and thermo-oxidative stabilities in resin composites across the range of aerospace "engineering thermoplastic" resins are improved by forming four crosslinks at each addition polymerization site in the backbone of the resin using crosslin... | 03/11/1997 |
| 5594089 | Heterocycle or heterocycle sulfone oligomers with multiple chemically functional end caps Thermomechanical and thermo-oxidative stabilities in heterocycle or heterocycle sulfone resin composites are improved by forming four crosslinks at each addition polymerization site in the backbone of the resin using crosslinking functionalities.... | 01/14/1997 |
| 5587105 | Methods for making liquid molding compounds using diamines and dicyanates Low molecular weight resins that usually are aliphatic and that include crosslinking thermal functional groups are useful as liquid molding compounds for reaction injection molding or resin transfer molding. The compounds eliminate the need to handle solv... | 12/24/1996 |
