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| Number | Title | Issue Date |
| 8119816 | Merocyanine dye and use thereof The present invention provides a blue laser light-absorbent substance, which is suitably used in organic photo conductor, laser optical data carrier or organic light-emitting diodes. The blue laser light-absorbent substance includes a merocyanine compound of the gen... | 02/21/2012 |
| 8049018 | Methine dyes and uses of the same The present invention provides novel organic compounds, which absorb the light in the ultra violet and the infrared regions, have improved light tolerance and solubility in solvents, and have thermal tolerance suitable for uses to which the organic compounds are app... | 11/01/2011 |
| 7947844 | One-pot synthesis of benzisoindolenines used in the preparation of naphthalocyanines A method of effecting a one-pot conversion of a tetrahydronaphthalic anhydride of formula (I): to a nitrate salt of a benzisoindolenine of formula (II): The method comprises heating... | 05/24/2011 |
| 7935830 | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-... | 05/03/2011 |
| 7847105 | Methods and compounds for preparing CC-1065 analogs A method of forming a CBI CC-1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed. ... | 12/07/2010 |
| 7825262 | One-pot preparation of a benzoisoindolenine salt from a tetrahydronaphthalic anhydride A method of effecting a one-pot conversion of a tetrahydronaphthalic anhydride to a benzisoindolenine salt is provided. The method comprises heating the tetrahydronaphthalic anhydride with a reagent mixture comprising ammonium nitrate. | 11/02/2010 |
| 7790906 | Method for the purification of betaines The invention relates to a method for purification of synthetically-produced compounds, comprising a betaine structure in the molecule, for example, indocyan green, characterized in that reaction by-products, starting materials and/or other impurities such as NaI us... | 09/07/2010 |
| 7767829 | Water-soluble fluoro-substituted cyanine dyes as reactive fluorescence labelling reagents Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R1, R2, R3, R4,... | 08/03/2010 |
| 7732619 | Stilbene derivatives, light-emitting element, display device, and electronic device A novel stilbene derivative is provided with motivation of providing a blue emissive material showing excellent color purity. The use of the stilbene derivative of the present invention allows the fabrication of a blue-emissive light-emitting element with excellent ... | 06/08/2010 |
| 7705162 | Indolium compounds and optical recording materials The indolium compounds of the present invention are represented by general formula (I) below and exhibit thermal decomposition behavior further suitable for optical recording materials used in an optical recording layer of an optical recording medium for high-speed ... | 04/27/2010 |
| 7674914 | Anthracene derivative, and light emitting element, light emitting device, electronic device using anthracene derivative A novel anthracene derivative represented by General Formula (1) is provided, which enables the production of a light-emitting element with high luminous efficiency and a long lifetime. A high-performance light-emitting device and electronic device in which the anth... | 03/09/2010 |
| 7511155 | Reagents and a method for saturation labelling of proteins A matched set of fluorescent dyes is provided, wherein each dye of the set is capable of covalent attachment to a protein and wherein each of the dyes has a molecular structure and a charge that is matched one with the other, such that relative electrophoretic mobil... | 03/31/2009 |
| 7423056 | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoi... | 09/09/2008 |
| 7402677 | Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives A TBET cassette including at least one xanthine- or pyronin-based compound as a donor or acceptor is disclosed. Also, a method of TBET cassette design in which four criteria may be used is provided. TBET cassettes may be used to label biological molecules, in clothi... | 07/22/2008 |
| 7388026 | Prodrugs of CC-1065 analogs Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the pr... | 06/17/2008 |
| 7375127 | Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) The present invention provides novel tetrahydrocarbazole derivatives which have improved properties and which can be employed as inhibitors of GPCRs. This results in the possibility of using the novel compounds to treat pathological conditions whose severity depends... | 05/20/2008 |
| 7338720 | Organic electroluminescent element An organic electroluminescent (EL) device which uses, as a luminescence-assisting agent, a novel coumarin derivative with a specific structure. The coumarin derivative effectively accelerates in such an organic EL device the transfer of excited energy in a host comp... | 03/04/2008 |
| 7335470 | Compilations of nucleic acids and arrays and methods of using them In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or p... | 02/26/2008 |
| 7332520 | Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved,... | 02/19/2008 |
| 7329760 | CC-1065 analog synthesis Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): and improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole ... | 02/12/2008 |
| 7323487 | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 01/29/2008 |
| 7300800 | Analyte detection system An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of fluorescent labels for coding the particles and an analyte specific flu... | 11/27/2007 |
| 7288561 | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor ... | 10/30/2007 |
| 7282511 | Isatine derivatives with neurotrophic activity The present invention relates to novel isatin derivatives, pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the invention, their use in the treatment of neurodegenerative diseases and for ... | 10/16/2007 |
| 7265146 | Integrin receptor inhibitors Provided are compounds of formula (I) wherein A, Q, W, X, Y, Z, R1 to R4, m and n are as defined herein. Compounds of the invention bind to α4 integrin receptors and thereby inhi... | 09/04/2007 |
| 7262306 | Chemiluminescent compounds and their use The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especial... | 08/28/2007 |
| 7252892 | Organic electroluminescence device An organic electroluminescent (EL) device which contains a novel coumarin derivative composed of a coumarin ring, a naphthalene ring with one or more hydrocarbon groups, and a five-membered hetero ring condensed with the naphthalene ring so as to give an electronic ... | 08/07/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7238814 | Compositions of S-nitrosothiols and methods of use The invention describes compositions and kits comprising 4-aza-4-(2-methyl-2-sulfanylpropyl) tricyclo(5.2.1.0)dec-8-ene-3,5-dione; 4-aza-4-(2-methyl-2-(nitrosothio)propyl) tricyclo(5.2.1.0)dec-8-ene-3,5-dione; 4-{1-methyl-1-((2,4,6-trimethoxyphenyl)methylt... | 07/03/2007 |
| 7235578 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom The invention provides processes of preparing 3-substituted 1-(chloromethyl)- 1,2-dihydro-3H-[ring fused indol-5-yl(amine-derived)] compounds of formula (I) and its analogues, or a physiologically functional derivative thereof, (I), wherein A and B together may repr... | 06/26/2007 |
| 7211599 | Use of etodolac to treat hyperplasia The present invention provides a therapeutic method to treat non-malignant diseases characterized by the excessive tissue growth, e.g., hyperplastic diseases, comprising administering to a mammal (e.g., human) afflicted with excessive tissue growth, an effective amo... | 05/01/2007 |
| 7192977 | Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R1 preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X is jo... | 03/20/2007 |
| 7189752 | Use of etodolac for the treatment of chronic lymphocytic leukemia A method of treating cancer is provided comprising administering an amount of etodolac or analog theteof to a subject afflicted with leukemia that is effective to reduce the viability and/or to sensitize leukemia cells to an anti-cancer agent. ... | 03/13/2007 |
| 7179655 | Protein profiling platform Methods and compositions are described for analyzing complex protein mixtures, such as proteomes, using activity-based probes. In particular, probes that specifically react with and bind to the active form of one or more target proteins are employed. Labeled peptide... | 02/20/2007 |
| 7176037 | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods inclu... | 02/13/2007 |
| 7175831 | Light sensitive compounds for instant determination of organ function Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 02/13/2007 |
| 7173056 | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independe... | 02/06/2007 |
| 7173047 | Benzo (f) insoindol derivatives and their use as ep4 receptor ligands Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, i... | 02/06/2007 |
| 7160909 | Cyclopenta[b]indole derivatives as sPLAinhibitors A novel class of tricyclic compounds of the following formula (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 01/09/2007 |
| 7157234 | Detection of very low quantities of analyte bound to a solid phase A microscale binding assay, analyte binding array, and kits are disclosed, which exploit the mass action law to harvest analyte from a liquid sample. This is achieved by fabrication of sorbent zones having up to ten times the binding capacity per unit area generally... | 01/02/2007 |
