Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7964739 | Process for the preparation of asenapine and intermediate products used in said process The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process. ... | 06/21/2011 |
| 7875729 | Process for making asenapine Asenapine and related trans-isomer bicyclic compounds can be obtained by reducing a compound of formula (C) to preferentially form a trans-isomer compound of formula (D), followed by subsequent ring closure to form a compound of formula (B) such as asenapine. | 01/25/2011 |
| 7872147 | Intermediate compounds for the preparation of -5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1-dibenz[2,3:6,7]oxepino[4,5-]pyrrole Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]py... | 01/18/2011 |
| 7812177 | Potassium channel opener having benzofuroindole skeleton The object of the present invention is to provide a potassium channel opener having benzofuroindole skeleton representing the following formula (I) wherein, R1 is hydrogen, R2 is CF3, R3 is COOH, R4 is hydrogen,... | 10/12/2010 |
| 7799931 | Spirocyclic cyclohexane compounds Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them. ... | 09/21/2010 |
| 7759498 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators Disclosed are compounds, compositions and methods for the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation. Such compounds are represented by Formula I as follows: ... | 07/20/2010 |
| 7750167 | Process for the preparation of asenapine and intermediate products used in said process The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process. ... | 07/06/2010 |
| 7417153 | Method for the production of 3-amino-5-(hydroxymethyl)cyclopentane-1,2-diol derivatives A method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl) cyclopenlane-1,2-diols of formula (I): (and/or the enantiomer), where R1 is H, C1-6-alkyl, C3-8-cycloalkyl or b... | 08/26/2008 |
| 7402579 | Quinobenzoxazine analogs and compositions The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, ... | 07/22/2008 |
| 7338973 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation. | 03/04/2008 |
| 7312203 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumo... | 12/25/2007 |
| 7307080 | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage The disclosure relates to compounds, pharmaceutical compositions and methods for inhibiting PARP by use of the disclosed compositions. The compounds of the disclosure have the following structures I, II and III: ... | 12/11/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7232842 | Kinase inhibitors and associated pharmaceutical compositions and methods of use The invention provides novel compounds useful as kinase inhibitors or as starting materials And/or intermediates in the synthesis of compounds useful as kinase inhibitors. The compounds have The general structure of formula (I) | 06/19/2007 |
| 7192497 | Thermally stable booster explosive and process for manufacture A thermally stable booster explosive and process for the manufacture of the explosive. The product explosive is 2,4,7,9-tetranitro-10H-benzo[4,5]furo[3,2-b]indole (TNBFI). A reactant/solvent such as n-methylpyrrolidone (NMP) or dimethyl formamide (DMF) is made sligh... | 03/20/2007 |
| 7144912 | Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Pyrrole-Type compound. The compounds, compositions... | 12/05/2006 |
| 7129261 | Cytotoxic agents The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 10/31/2006 |
| 7087600 | Peptidyl prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 08/08/2006 |
| 7015334 | Thermally stable booster explosive and process for manufacture A thermally stable booster explosive and process for the manufacture of the explosive. The product explosive is 2,4,7,9-tetranitro-10H-benzo[4,5]furo[3,2-b]indole (TNBFI). A reactant/solvent such as n-methylpyrrolidone (NMP) or dimethyl formamide (DMF) is made sligh... | 03/21/2006 |
| 6962780 | Method for synthesis of nucleic acids The present invention is a method for synthesis of nucleic acids to amplify an intended nucleic acid in a region in which a GC content is rich, wherein a polyhydric alcohol and/or ammonium sulfate is present in an amplification reaction solution. According to the pr... | 11/08/2005 |
| 6927234 | Xanthone derivatives, method of production thereof, and pharmaceutical composition containing the same Biologically active xanthone derivatives, as well as compositions prepared from such derivatives, possessing anti-cancer activity, anti-inflammatory activity, anti-obesity activity, and/or hair growth promotion activity, and a method for producing such derivatives a... | 08/09/2005 |
| 6887892 | Tricyclic derivatives of indole with antiangiogenic activity Compounds of formula useful for treating tumors, particularly mammary carcinoma and colon carcinoma. ... | 05/03/2005 |
| 6849619 | Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, ... | 02/01/2005 |
| 6719925 | Naphthopyrans with a heterocycle in the 5, 6-position, preparation, and (co)polymer compositions and matrices containing them The present invention relates to novel compounds of the naphthopyran type with a fused heterocycle in the 5,6-position. These compounds have formula (I) or (II) given below: These compounds (I) or (II) have valuable phot... | 04/13/2004 |
| 6699852 | Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) ##STR1## or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9... | 03/02/2004 |
| 6699899 | Substituted acylhydroxamic acids and method of reducing TNF levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate.... | 03/02/2004 |
| 6548493 | Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) ##STR1## or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8 | 04/15/2003 |
| 6514983 | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula: ##STR1## or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein Y is alkylhalo, alkyl-CO--G, COG, a direct bond... | 02/04/2003 |
| 6433175 | Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists A chemical compound of formula (I), wherein n is 1, 2 or 3; R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydro... | 08/13/2002 |
| 6399780 | Isomeric fused pyrrolocarbazoles and isoindolones The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is a... | 06/04/2002 |
| 6391902 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers Compounds of the Formulae (I) and (II): ##STR1## wherein R1, R2, R3, X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth muscle contraction via pot... | 05/21/2002 |
| 6369238 | Processes for the preparation of derivatives of 4a, 5, 9, 10, 11, 12-hexahydro-6H-benzofuro-[3a, 3, 2-ef][2]benzazepine The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a, 5,9,10,11... | 04/09/2002 |
| 6306889 | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage This invention relates to compounds, pharmaceutical compositions, and methods for the treatment or prevention of neural or cardiovascular tissue damage related to cerebral ischemia and reperfusion injury in an animal by administering Poly(ADP-ribose) poly... | 10/23/2001 |
| 6288099 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers Compounds of the Formulae (I) and (II): ##STR1## wherein R1, R2, R3, X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth muscle contraction via pot... | 09/11/2001 |
| 6284896 | Abeo-ergoline derivatives as 5HT1A ligands There are provided compounds of formula (I), wherein R.sub.1 is a hydrogen, chlorine or bromine atom or a methyl, methylthio, hydroxy, cyano or carboxamido group; R.sub.2 is C.sub.1 -C.sub.3 alkyl or an alkyl group; R.sub.3 and R.sub.4 are independently a... | 09/04/2001 |
| 6281354 | Analogs of duocarmycin and cc-1065 The field of this invention is antitumor antibiotics. More particularly, the present invention relates to analogs of duocarmycin and CC-1065, which analogs have antitumor antibiotics activity.... | 08/28/2001 |
| 6203729 | [Pyrrole]naphthopyranes, their preparation, and compositions and (co)polymer matrices containing them Disclosed are naphthopyran-type compounds having a pyrrole group annelated in position 5.6, as well as compositions and particularly (co)polymer matrices containing them. These compounds, compositions, and matrices have photochromic properties. These [pyr... | 03/20/2001 |
| 6162822 | Bisimide compounds A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1, X and Y, which may be identical or different, represent hydrogen or halogen or alky, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylam... | 12/19/2000 |
| 6153645 | Heterocycles as antimicrobial agents Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as ant... | 11/28/2000 |
| 6133288 | Pentacyclic compounds, intermediates, processes, compositions, and methods The present invention provides compounds of formula I and II: ##STR1## wherein X is --O--, --S--, or --NR5 --; Y is --O--, --S--, --CH2 --, --CH2 CH2 --, --CH.dbd.CH--, or --NR5 --; B is --CH2 | 10/17/2000 |
