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| Number | Title | Issue Date |
| 7420065 | Hetero-polycyclic compounds, and coloring matters, pigments, dyes, color-changing material compositions, and color-changing films, made by using the compounds Provided are novel hetero-polycyclic compounds having a specific structure, color-changing material compositions comprising (A) a fluorescent coloring matter comprising at least one of the hetero-polycyclic compounds described above and (B) a binder material, color-... | 09/02/2008 |
| 7408072 | Heteropolycyclic compound and dye The present invention provides heteropolycyclic compounds represented by General Formulae (1) and (2): wherein R1 is a straight- or branched-chain C1-C10 alkyl group or the like; R2 | 08/05/2008 |
| 7388024 | Indeno[2,1A]indenes and isoindolo[2,1-A]indoles The present invention provides indeno[2,1a]indene and isoindolo[2,1-a]indole derivatives of the Formula I, its salts and its stereoisomers, wherein X, R1, R2, R3, R4, R6, R7, R8, R9 | 06/17/2008 |
| 7354947 | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto Isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2... | 04/08/2008 |
| 7348425 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 03/25/2008 |
| 7317035 | Tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tetracyclic arylcarbonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel int... | 01/08/2008 |
| 7309532 | Cyclopentaphenanthrene-based compound and organoelectroluminescent device employing the same The present invention is related to a cyclopentaphenanthrene-based compound and an organic electroluminescence device using the same. In particular, the cyclopentaphenanthrene-based compound offers several advantages, including easy processibility, high solubility, ... | 12/18/2007 |
| 7297711 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tetracyclic arylalkyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel interm... | 11/20/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7192977 | Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R1 preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X is jo... | 03/20/2007 |
| 7153848 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 12/26/2006 |
| 7129261 | Cytotoxic agents The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 10/31/2006 |
| 7122679 | Multicyclic compounds and the use thereof The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for e... | 10/17/2006 |
| 7094798 | Inhibitors of checkpoint kinases (Wee1 and Chk1) This invention relates to pyrrolocarbazole derivatives according formula I wherein R1, R2, R7, R8, R9, X and Y are as defined in the specification wherein said derivatives specifically inhibit one or both of the... | 08/22/2006 |
| 7087600 | Peptidyl prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 08/08/2006 |
| 6992100 | sPLAinhibitors A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 01/31/2006 |
| 6872743 | sPLA2 inhibitors A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 medi... | 03/29/2005 |
| 6844445 | Indenoindolone compounds Compound of formula (I): wherein: R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl, each of R1 to R8, whi... | 01/18/2005 |
| 6627650 | Indenoindolone compounds A compound of formula (I): ##STR1## wherein: R represents hydrogen, optionally substituted alkyl or alkenyl, R1 to R8, which may be identical or different, each represents hydrogen, optionally substituted alkyl, hydroxy, acyloxy, ... | 09/30/2003 |
| 6576780 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 06/10/2003 |
| 6548530 | CBI analogs of CC-1065 and the duocarmycins Analogs of the antitumor antibiotics CC-1065 and the duocarmycins incorporate the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) alkylation subunit. The CBI-based analogs have potent cytotoxic activity and are useful as efficacious antitumor com... | 04/15/2003 |
| 6486326 | iso-CBI and iso-CI analogs of CC-1065 duocarmycins A series of bioactive analogs of (+)-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA bin... | 11/26/2002 |
| 6482567 | Oxime sulfonate and N-oxyimidosulfonate photoacid generators and photoresists comprising same New photoacid generator compounds ("PAGs") are provided and photoresist compositions that comprise such compounds. In particular, non-ionic PAGs are provided that contain an oxime sulfonate group, and/or an N-oxyimidosulfonate group. PAGs of the invention... | 11/19/2002 |
| 6465660 | Isoindoloindolone compounds Compound of formula (I): ##STR1## wherein: R1, R2, R3, R4, R5, R6 and R8, which may be identical or different, each represents hydrogen, alkyl, arylalkyl, hydroxy, alkoxy, arylal... | 10/15/2002 |
| 6440889 | Amine elimination process for making single-site catalysts An amine-elimination process for making single-site catalysts is disclosed. First, an indenoindole or its synthetic equivalent reacts with a tetrakis(dialkylamino) Group 4 metal compound to give a tris(dialkyl-amino) compound. This versatile intermediate ... | 08/27/2002 |
| 6326391 | Inhibitors of multidrug transporters The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or... | 12/04/2001 |
| 6281355 | Nitrogen-containing tetracyclic compounds A nitrogen-containing tetracyclic compound represented by the formula: ##STR1## wherein Y1 --Y2 --Y3 is N--C.dbd.N or a group represented by the formula: C.dbd.C--NR3 (wherein R3 is a hydrogen atom, a ... | 08/28/2001 |
| 6262271 | ISO-CBI and ISO-CI analogs of CC-1065 and the duocarmycins A series of bioactive analogs of (+)-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA bin... | 07/17/2001 |
| 6147105 | 2-phenylindoles as antiestrogenic pharmaceutical agents Novel 2-phenyl indoles are disclosed of general formula (I), wherein: R1 represents one of the rests --(CH2)n --S(O)m --R4, --(CH2)n --NR6 --SO2 --R4,... | 11/14/2000 |
| 6069153 | Indenoindoles and benzocarbazoles as estrogenic agents The present invention relates to new substituted benzo[a]carbozoles and indenoindoles which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, having the general structures below. ... | 05/30/2000 |
| 6063803 | Octahydropyrrolo-[3,4-c]carbazoles useful as analgesic agents This invention relates to a series of compounds of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. Compounds of the invention alleviate pain in animal models at levels comparable to known an... | 05/16/2000 |
| 6060608 | Analogs of CC-1065 and the duocarmycins Analogs of antitumor antibiotics CC-1065 and the duocarmycins are synthesized which possess systematic and extensive modifications in the DNA binding subunits attached to a 1,2,9,9a-tetra-hydro-cyclo-propa[c]benz[e]indol-4-one (CBI) alkylation subuni... | 05/09/2000 |
| 6022379 | Pyrrole derivatives of 1,4-naphthoquinone and of 1,4-dihydroxynaphthalene for dyeing keratin fibers, compositions comprising the same, and dyeing process Pyrrole derivatives of 1,4-naphthoquinone and of 1,4-dihydroxynaphthalene, dye compositions containing them and the corresponding dyeing process.... | 02/08/2000 |
| 5917052 | Hypoglycemic agent from cryptolepis The use of extracts from Cryptolepis sp. or quindoline alkaloids such quindoline and cryptolepine contained therein as hypoglycemic agents, as well as methods for obtaining the hypoglycemic agents are described. According to a preferred embodiment, the ex... | 06/29/1999 |
| 5753790 | Hypoglycemic agent from cryptolepis The use of extracts from Cryptolepis sp. or quinodoline alkaloids such quindoline and cryptolepine contained therein as hypoglycemic agents, as well as methods for obtaining the hypoglycemic agents are described. According to a preferred embodiment, the e... | 05/19/1998 |
| 5719174 | Indenoindole compounds for use in organ preservation The use of antioxidants having indenoindole structure as additives to organ preservation solutions. Such a preservation solution is useful both for in site organ treatment in the donor and for organ storage after the organ is harvested. The present invent... | 02/17/1998 |
| 5708001 | Substituted 6-azaandrostenones The present invention relates to certain substituted 17ଲ-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R1 and R2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R | 01/13/1998 |
| 5676884 | Nonlinear optical materials containing polar disulfone-functionalized molecules Nonlinear optical (NLO) compositions are disclosed which contain polar disulfone-functionalized molecules (PDFMs) incorporated in a polymeric material. when aligned noncentrosymmetrically in the polymeric material, the PDFMs generate a second-order NLO re... | 10/14/1997 |
| 5585499 | Cyclopropylbenzindole-containing cytotoxic drugs Novel cytotoxic agents comprising a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described. These cytotoxic agents have therapeutic use because the... | 12/17/1996 |
| 5543406 | Inhibitors of 5--testosterone reductase The present invention relates to certain substituted 17ଲ-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) ##STR1## wherein R1 and R2 are i) independently hydrogen or lower alky... | 08/06/1996 |
