Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7365092 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they ac... | 04/29/2008 |
| 7365091 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful fo... | 04/29/2008 |
| 7351730 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,... | 04/01/2008 |
| 7345082 | Phosphinic acids The present invention relates to phosphinic acid derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prev... | 03/18/2008 |
| 7339066 | Intermediates for the synthesis of polypropionate antibiotics The invention relates to intermediate compounds of the formula wherein R1 is H or a protecting group, R2 and R3 each independently represent H, methyl, or a leaving group, provided that at l... | 03/04/2008 |
| 7332603 | Preparation of biphosphonic acids and salts thereof A process for preparing alendronate sodium includes the reaction of gammabutyric acid with phosphorous acid and phosphorus trichioride and subsequent treatment with an aqueous solution of an alkali metal hydroxide, in which the reaction is conducted in liquid ionic ... | 02/19/2008 |
| 7314941 | Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the ... | 01/01/2008 |
| 7297807 | Intermediates for the synthesis of polypropionate antibiotics The invention relates to intermediate compounds of the formula wherein R1 is H or a protecting group, R2 and R3 each independently represent H, methyl, or a leaving group, provided that at l... | 11/20/2007 |
| 7268124 | Geranylgeranyl pyrophosphate synthase inhibitors The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use. ... | 09/11/2007 |
| 7223879 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. ... | 05/29/2007 |
| 7148361 | Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the ... | 12/12/2006 |
| 7141377 | Process for discrimination of nucleic acid sequence variants A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for det... | 11/28/2006 |
| 7119090 | Pyrrole substituted 2-indolinone protein kinase inhibitors The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of prot... | 10/10/2006 |
| 7115738 | Hydroxyproline/phosphono oligonucleotide analogues, methods of synthesis and methods of use Compounds are described and claimed comprising general formula: The compounds have substituents as described herein and are useful, e.g., for their ability to bind nucleic acids and thereby effect purifications, ... | 10/03/2006 |
| 7078532 | Process for manufacture of fosinopril sodium The present invention discloses a process for the synthesis of fosinopril as a single desired isomer of high purity in two steps comprising of (a) preparation of fosinopril as a mixture of four diastereomers and (b) separation of the desired isomer from the mixture ... | 07/18/2006 |
| 7045511 | Fosinopril formulation A pharmaceutical formulation is provided comprising fosinopril which is the prodrug of an angiotensin converting enzyme (ACE) inhibitor, fosinoprilat. The formulation is characterized by comprising in the range of about 0.25 to about 5% glyceryl dibehenate which has... | 05/16/2006 |
| 7026498 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react... | 04/11/2006 |
| 7005442 | 8-azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification. ... | 02/28/2006 |
| 6977303 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence,... | 12/20/2005 |
| 6951883 | 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof 2H-1-Benzopyran derivatives, processes for their preparation and use thereof for the preparation of pharmaceutical compositions for the prevention and treatment of postmenopausal pathologies. ... | 10/04/2005 |
| 6946560 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react... | 09/20/2005 |
| 6939886 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor Type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8 | 09/06/2005 |
| 6906097 | 8-azaprostaglandin analogs as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 06/14/2005 |
| 6878830 | Catalytic boronate ester synthesis from boron reagents and hydrocarbons A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydr... | 04/12/2005 |
| 6812240 | 8-azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification. ... | 11/02/2004 |
| 6800654 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are eachH, alkyl,, alkanoyl, halo, OH, aryl optionally substituted with R8 | 10/05/2004 |
| 6784191 | Benzamidine derivatives A benzamidine derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an effect of inhibiting the blood coagulation based on their excellent effect of inhibiting activated blood-coagulation factor X. Thus, a blood-coag... | 08/31/2004 |
| 6753431 | Production of mixed acid anhydride and amide compound There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p (1) wherein R1, R2 and Y denote the same as defined bel... | 06/22/2004 |
| 6734201 | 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification. ... | 05/11/2004 |
| 6734206 | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 05/11/2004 |
| 6699884 | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: ##STR1## wherein A, X, n, R1... | 03/02/2004 |
| 6696081 | Carbohydrate based lipid compositions and supramolecular structures comprising same Novel lipid compounds and compositions comprising carbohydrate backbones are used to make supramolecular structures such as vesicles, liposomes (single lamellar, multilamellar, and giant), micelles, hexagonal phases, microemulsions and others. The novel c... | 02/24/2004 |
| 6686477 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reactio... | 02/03/2004 |
| 6555567 | Substituted spiroheterocyclic 1H-3-aryl-pyrrolidine-2,4-dione derivatives, processes for their preparation, and their use as pesticides The invention concerns substituted spiro heterocyclic 1H-3-arylpyrrolidine-2,4-dione derivatives depicted by the formula: ##STR1## X is alkyl, halogen or alkoxy; Y is hydrogen, alkyl, halogen, alkoxy or alkyl halide; Z is alkyl, halogen or alkoxy; n is 0,... | 04/29/2003 |
| 6509359 | Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors A compound having the formula: ##STR1## wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.... | 01/21/2003 |
| 6492351 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith The compounds of formulae IIA, the structure: ##STR1## wherein R1, R2, and X4, X5, n are as described in the specification.... | 12/10/2002 |
| 6485886 | Oxime derivatives and the use thereof as latent acids New oxime derivatives of formula (I) or. (II), wherein m is 0 or 1; R1 inter alia is phenyl, naphthyl, anthracyl, phenanthryl or a heteroaryl radical; R'1 is for example C2 -C12 alkylene, phenylene, naphthylene;... | 11/26/2002 |
| 6479471 | NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzym... | 11/12/2002 |
| 6472419 | 1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents The present invention relates to new 1-H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, G, X, Y and Z have the meanings given in the description, to processes for their preparation, and to intermediates therefor. The ... | 10/29/2002 |
| 6452004 | Cyclopentenecarboxamide derivative, method for preparing the same bicycloamide derivative used therein A cyclopentenecarboxamide derivative represented by the formula (I): ##STR1## and a method for preparing the cyclopentencarboxamide derivative. A bicycloamide derivative represented by the formula (II): ##STR2## and a method for preparing the bicycloamide... | 09/17/2002 |
