Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 8138352 | Method for producing asymmetric tetrasubstituted carbon atom-containing compound The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent. Specifically, the invention provides a method for producing a compound of formula (2): | 03/20/2012 |
| 7842818 | Process for preparation of tetrasubstituted 5-azaspiro[2.4]- heptane derivatives and optically active intermediates thereof The present invention provides a method for effectively producing an optically active form of tetrasubstituted-5-azaspiro[2.4]heptane derivative, which serves as a useful production intermediate for quinolonecarboxylic acid antibacterial agents, and intermediates fo... | 11/30/2010 |
| 7786312 | Methods of preparing heterocyclic boronic acids and derivatives thereof In the context of synthesizing heterocyclic boronic acid compounds, a convergent synthetic methodology is particularly efficient for preparing boropyrrolidines and derivatives of boropyrrolidines. ... | 08/31/2010 |
| 7632953 | Process for the preparation of gabalactam The present invention provides an improved process for the preparation of gabalactam of formula 1 that includes preparing an aqueous solution of an alkali or alkaline earth metal hydroxide, adding bromine to the resulting s... | 12/15/2009 |
| 7439371 | Indol kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 10/21/2008 |
| 7407982 | Oligo or polyalkylene glycol-coupled thrombin inhibitors The present invention relates to novel covalent oligo and polyalkylene glycol conjugates with synthetic inhibitors of trypsin-type serine proteases, in particular inhibitors of the hemocoagulation protease thrombin, synthetic intermediates stages required in their p... | 08/05/2008 |
| 7399857 | Synthesis of organometallic cyclometallated transition metal complexes A process for forming a tris-cyclometallated complex comprises the step of reacting; a) an M(I) complex, wherein M represents Rh or Ir, and said complex comprises at least two ligands and contains at least two alkenyl groups pi-bon... | 07/15/2008 |
| 7396846 | Growth hormone secretagogues This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in thes... | 07/08/2008 |
| 7297788 | Regioselective hydroxylation, functionalisation and protection of spirolactams The present invention refers to highly functionalised spiro-fused azetidinones of formula I: having a cyclohexane moiety with the desired number of protected or unprotected hydroxyl groups which are introduced with high ste... | 11/20/2007 |
| 7291728 | Spirolactams and their synthesis The present invention is directed to a compound of formula I: wherein R1 and R2 are independently selected from H, halogen, protected or unprotected hydroxy, alkylsilyloxy, substituted or un... | 11/06/2007 |
| 7244750 | Active substance combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/17/2007 |
| 7238703 | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT, and neuronal nicotinic receptor antagonists Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of tr... | 07/03/2007 |
| 7232845 | Active substance combinations comprising insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 06/19/2007 |
| 7227043 | 2-phenyl-2-substituted-1,3-diketones The invention relates to novel phenyl-substituted cyclopentane- and cyclohexane-1,3-dione derivatives of the formula (I) in which W, X, Y, Z, A, B, Q1, Q2, Q3 | 06/05/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7205289 | Combinations of active ingredients with insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 04/17/2007 |
| 7183238 | [1,2]-oxazine-3,5-diones The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a pl... | 02/27/2007 |
| 7148246 | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals The invention relates to cycloalkyl derivatives having bioisosteric carboxylic acid groups and to t... | 12/12/2006 |
| 7141679 | Process for making N-vinyl-2-pyrrolidone A process for making N-vinyl-2-pyrrolidone (NVP) is disclosed. The process comprises dehydrating N-(2-hydroxyethyl)-2-pyrrolidone (HEP) in the presence of a catalyst and added water. Adding an effective amount of water into the dehydration process reduces the amount... | 11/28/2006 |
| 7138542 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hy... | 11/21/2006 |
| 7122678 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 10/17/2006 |
| 7122677 | NK1 antagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5... | 10/17/2006 |
| 7109350 | Process for the preparation of optically active amines or salts thereof A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a): wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R | 09/19/2006 |
| 7098362 | Processes for the preparation of gabapentin The present invention relates to new processes for the preparation of gabapentin by the desilylation of a silylated gabapentin or by the silylation-desilylation of an acid addition salt of gabapentin with a silylating agent. ... | 08/29/2006 |
| 7098225 | Active compound combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 08/29/2006 |
| 7091233 | Active substance combinations comprising insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 08/15/2006 |
| 7087635 | 3-substituted oxindole β3 agonists The present invention relates to a β3 adrenergic receptor agonist of formula I: or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is usefu... | 08/08/2006 |
| 7084138 | Active ingredient combinations with insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro... | 08/01/2006 |
| 7060692 | Active ingredient combinations comprising insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro... | 06/13/2006 |
| 7053114 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related c... | 05/30/2006 |
| 7026505 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen ... | 04/11/2006 |
| 6994866 | Combinations of active ingredients, which exhibit insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in... | 02/07/2006 |
| 6982337 | Process for making N-vinyl-2-pyrrolidone A process for making N-vinyl-2-pyrrolidone (NVP) is disclosed. The process comprises dehydrating N-(2-hydroxyethyl)-2-pyrrolidone (HEP) in the presence of a catalyst and added water. Adding an effective amount of water into the dehydration process reduces the amount... | 01/03/2006 |
| 6939888 | 1-H-3-arylpirrolidine-2,4-dione derivatives The invention concerns 1-H-3-arylpyrrolidine-2,4-dione derivatives of formula (I), in which A, B, G, X, Y and Z are as defined in the description, methods of preparing them and intermediates used in their preparation. ... | 09/06/2005 |
| 6921835 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 07/26/2005 |
| 6919090 | Active substance combinations with insecticidal and acaricidal properties The invention relates to novel active combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/19/2005 |
| 6906197 | Process for the preparation of optically active amines or salts thereof A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a) wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a | 06/14/2005 |
| 6906053 | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R | 06/14/2005 |
| 6906007 | Phenyl-substituted 5,6-dihydropyrone derivatives for use as pesticides and herbicides The present invention relates to novel phenyl-substituted 5,6-dihydro-pyrone derivatives of the formula (I) in which W, X, Y, Z, G, A, B, Q1 and Q2 are each as defined in the description... | 06/14/2005 |
| 6894005 | Herbicides Compounds of formula wherein the substituents have the meanings given in claim 1, and agronomically tolerable salts, isomers and enantiomer of those compounds, are suitable for use as herbicides. ... | 05/17/2005 |
