Class 548/407 - Spiro

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which contain a spiro ring system.
No. of patents: 182
Last issue date: 02/28/2012

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Number	Title	Issue Date
8124788	Spirocyclic cyclohexane compounds with analgesic activity Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the...	02/28/2012
7439263	Pyrrolidine and thiazolidine compounds Compounds of formula (I): wherein: X1 represents an atom or group selected from CR4aR4b, O, S(O)q1 and NR5, wherein R4a, R...	10/21/2008
7417153	Method for the production of 3-amino-5-(hydroxymethyl)cyclopentane-1,2-diol derivatives A method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl) cyclopenlane-1,2-diols of formula (I): (and/or the enantiomer), where R1 is H, C1-6-alkyl, C3-8-cycloalkyl or b...	08/26/2008
7339066	Intermediates for the synthesis of polypropionate antibiotics The invention relates to intermediate compounds of the formula wherein R1 is H or a protecting group, R2 and R3 each independently represent H, methyl, or a leaving group, provided that at l...	03/04/2008
7332519	Spirocyclic cyclohexane compounds Spirocyclic cyclohexane compounds, methods for their production, pharmaceutical compositions containing these compounds, and the use of these spirocyclic cyclohexane compounds for treating conditions associated with the nociceptin/ORL1 receptor system, e.g. pain, dr...	02/19/2008
7329634	3-Phenyl substituted 3-substituted-4ketolactams and ketolactones The invention relates to novel 3-phenyl-substituted, 3-substituted 4-ketolactams and -lactones of the formula (I) in which Q, W, X, Y, A, B and G are as defined in the disclosure, to proc...	02/12/2008
7297807	Intermediates for the synthesis of polypropionate antibiotics The invention relates to intermediate compounds of the formula wherein R1 is H or a protecting group, R2 and R3 each independently represent H, methyl, or a leaving group, provided that at l...	11/20/2007
7288560	Spirocyclic cyclohexane derivatives The present invention relates to spirocyclic cyclohexane compounds, to methods for their production, to pharmaceutical compositions containing these compounds, to methods of treatment using such compounds and to the use of such spirocyclic cyclohexarie compounds for...	10/30/2007
7265110	Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates compounds of the formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, and R10 represent a variety of substituents; A represents NR9 ...	09/04/2007
7220868	Process for the preparation of novel dyes for use in imaging members There are described novel rhodamine dye compounds and imaging members and imaging methods, including thermal imaging members and imaging methods, utilizing the compounds. The dye compounds exhibit a first color when in the crystalline form and a second color, differ...	05/22/2007
7179912	Materials and methods to potentiate cancer treatment Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed....	02/20/2007
7126009	Palladium catalyzed indolization of 2-bromo or chloroanilines The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I) (I)	10/24/2006
7122677	NK1 antagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5...	10/17/2006
7109350	Process for the preparation of optically active amines or salts thereof A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a): wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R	09/19/2006
6962938	Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE) The present application describes novel spiro-cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms ...	11/08/2005
6911463	3-substituted oxindole β-3 agonists The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity. ...	06/28/2005
6908934	Therapeutic compounds for treating dyslipidemic conditions Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia	06/21/2005
6906053	Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R	06/14/2005
6890915	Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R	05/10/2005
6822094	Spiro compounds and their use Spiro compounds of the formula (I), in which at least one of the radicals K1, L, M, N1, R1, R2, R3, R4 is one of the following groups ...	11/23/2004
6797708	Inhibitors of cytosolic phospholipase A2 This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase ...	09/28/2004
6683709	Photochromic pyran compounds Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from naphthopyrans, which are known as spirofluorenopyrans. By int...	01/27/2004
6548679	Antitumor agents The present invention provides compounds of general formula I or II: ##STR1## wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceu...	04/15/2003
6395743	HIV integrase inhibitors Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination w...	05/28/2002
6340765	Chromene compound A photochromic compound having a high color-developing sensitivity, a large fading rate and good durability of photochromic property. A novel chromene compound is, for example, represented by the following formula, ##STR1## and in which, as a basic struct...	01/22/2002
6315928	Spirofluorenopyrans The present invention relates to specific photochromic 3H-naphtho[2,1-b]pyran derivatives and to their use in plastics of all types, especially for ophthalmic purposes. In particular, the present invention relates to spiro compounds derived from naphthopy...	11/13/2001
6203729	[Pyrrole]naphthopyranes, their preparation, and compositions and (co)polymer matrices containing them Disclosed are naphthopyran-type compounds having a pyrrole group annelated in position 5.6, as well as compositions and particularly (co)polymer matrices containing them. These compounds, compositions, and matrices have photochromic properties. These [pyr...	03/20/2001
6140051	Fluorescent dibenzazole derivatives and methods related thereto Dibenzazole compounds having the general structure: ##STR1## wherein; R1, R2, R3, R4, R5, R6 are independently H or a substituent which aids in solubility of the compound or which prov...	10/31/2000
6130101	Sulfonated xanthene derivatives The present invention describes xanthene dyes, including rhodamines, rhodols and fluoresceins that are substituted one or more times by a sulfonic acid or a salt of a sulfonic acid. The dyes of the invention, including chemically reactive dyes and dye-con...	10/10/2000
6110400	Fulgimide compound and use thereof and composition containing said compound A novel fulgimide compound in which the nitrogen atom of the imide ring is substituted by a phenyl group having an electron-attracting group at least at the meta position, which is represented by the following general formula (I): ##STR1## [wher...	08/29/2000
6100265	Thiopyran derivatives A thiopyran derivative represented by the following formula (I) or (I'), or the salt thereof. ##STR1## wherein A is S or --CH.dbd.CH--; the dotted line indicates that the bond may be either present or absent; Z and Z' are typically ##STR2## ...	08/08/2000
6048877	Tetralone derivatives as antiarrhythmic agents Tetralone derivatives of the formula ##STR1## where R1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, ...	04/11/2000
5977111	Thiopyran derivatives A thiopyran derivative represented by the following formula (I) or (I'), or the salt thereof. ##STR1## wherein A is S or --CH.dbd.CH--; the dotted line indicates that the bond may be either present or absent; Z and Z' are typically ##STR2## ...	11/02/1999
5968968	Diphenyl-cyclopropenes as selective K-agonists Diphenyl-cyclopropene derivatives, their nontoxic, pharmaceutically acceptable acid addition salts and compositions are kapa opiods useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irri...	10/19/1999
5962504	Substituted 2-pyrrolidinone activators of PKC Compounds of formula I: ##STR1## wherein R1 and R2 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC activators and are useful for treating diseases, such as, for example, ...	10/05/1999
5840217	Spiro compounds and their use as electroluminescence materials Use of spiro compounds of the formula (I) ##STR1## where K1 and K2 are, independently of one another, conjugated systems, in electroluminescence devices. Preferred compounds of the formula (I) are 9,9'-spirobifluorene derivatives ...	11/24/1998
5811551	Palladium catalyzed indolization We have found that indoles of structural formula (III): ##STR1## can be cost-effectively synthesized in high yield by the palladium-catalyzed coupling/ring closure of a 2-halo- or 2-trifluoromethylsulfonyl-aniline and a cyclic ketone derivative. The ...	09/22/1998
5773630	Process for the preparation of N-substituted cyclic imides N-Substituted cyclic imides are obtained by reacting a cyclic acid anhydride with an amine in the presence of a solvent and an acid catalyst at 80° to 200° C. and with removal of the water formed, it being particularly advantageous to carry out this rea...	06/30/1998
5739078	Fluoran compounds, intermediates and color forming recording materials By using the fluoran compound represented by the following general formula (I); ##STR1## wherein R1 is alkyl containing 1 to 4 carbon atoms, R3 is alkyl containing 1 to 8 carbon atoms, R4 is hydrogen or alkyl containi...	04/14/1998
5723625	Process for the production of specific isomer mixtures from oxindole alkaloids To produce defined isomer mixtures of compounds with spirocyclic beta-aminocarboxyl and/or beta-aminocarbonyl systems the invention supposes that they be dissolved in solvents which have good dissolving power for these compounds, whose relative permittivi...	03/03/1998

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Class 548/407 - Spiro